DRUG UTILIZATION EVALUATION OF BENZODIAZEPINES IN A TERTIARY CARE HOSPITAL

P. RAMA; R.  MONISHA; SUSAN VARGHESE PAUL; VARSHA ELSA SCARIA; P. JANANI; SANTHOSH PERUMAL

doi:10.22159/ijpps.2019v11i11.35359

Authors

P. RAMA Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamilnadu, India
R. MONISHA Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamilnadu, India
SUSAN VARGHESE PAUL Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamilnadu, India
VARSHA ELSA SCARIA Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamilnadu, India
P. JANANI Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamilnadu, India
SANTHOSH PERUMAL Department of Neurology, PSG Hospitals, Coimbatore, Tamilnadu, India

DOI:

https://doi.org/10.22159/ijpps.2019v11i11.35359

Keywords:

Benzodiazepines, Drug utilization, Naranjo adverse drug reaction scale, DIPS, DDD

Abstract

Objective: To assess the rationale use of benzodiazepines among various departments in a multi-speciality hospital.

Methods: A prospective study was conducted with a sample size of 200 for a period of six months. Data was collected from patients based on inclusion and exclusion criteria. Naranjo Adverse Drug Reaction Probability Scale and Drug Interaction Probability Scale (DIPS) were used as a study tool to measure the causality of adverse drug reactions and drug interactions. Based on the dosage of various benzodiazepines DDD was calculated and compared with WHO Anatomical Therapeutic Chemical (ATC) classification Defined Daily Dose (DDD).

Results: BZD’s were mostly prescribed in males (74.5%) and married patients (86.5%) were more exposed to benzodiazepines compared to others. Lorazepam (70.1%) was found to be the most commonly used drug, mainly prescribed for sedation, followed by anxiety. DDD was calculated and majority of patients had DDD in accordance with WHO standard. Based on cost analysis, Clobazam was found to be the high cost and Lorazepam being the low-cost drug. The results of drug utilization evaluation of benzodiazepines study were compiled and reported to the respected department physician and their feedback was collected.

Conclusion: The study showed a rational utilization of benzodiazepines and the negative outcomes of BZDs can be reduced by providing drug-related information to the prescribers and consumers.

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