OPTIMIZATION OF THE TECHNOLOGY FOR PRODUCING A MAGNETO CONTROLLABLE NANOCOMPOSITE Ag@Fe3O4 USING MATHEMATICAL DESIGN

Authors

  • ОLEG S. KRYSKIV National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • TETYANA M. CHAN National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • ALLA O. KOVAL National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • OLEG S. SHPYCHAK National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • KATERYNA P. ROMAS National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • OLEKSANDRA S. KRAN National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • TETIANA V. MARTYNIUK National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • OLGA V. ANTONENKO National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002

DOI:

https://doi.org/10.22159/ijpps.2020v12i1.35870

Keywords:

Synthesis, Technology, Nanoparticles, Silver shell, Magneto controllable composite system, Methods of mathematical design, Regression and correlation analysis, Response surface methodology

Abstract

Objective: The purpose of the research was to optimize technology for producing a magneto controllable nanocomposite Ag@Fe3O4 with modern physicochemical and therapeutic requirements using methods of mathematical design of the experiment.

Methods: To optimize the synthesis process of the nanocomposite Ag@Fe3O4, the method of factor experiment was used. Mathematical calculations were performed using the STATISTICA 10 StatSoft Inc. system and Excel spreadsheet processor of MS Office 2019 Professional Plus.

Results: Based on the study of technological parameters of nanocomposite synthesis Ag@Fe3O4 (16 experiments) a regression equation was obtained: Y = 106.415+0.038X1+4.448Х2+1.806Х3–1.593Х4–18.945Х5–109.980Х6. By the use of this equation the synthesis parameters were optimized with the help of steepest ascent method. It was found that the maximum yield of Ag@Fe3O4 can be achieved under the following conditions: X1 (magnetite synthesis time, min)–40; X2 (glucose content in solution,%)–10; X3 (temperature of the Tollens reaction, °С)–65; X4 (magnetite silver coating time, min)–30; X5 (pH, units)–8.5; X6 (rate of addition of ammonia, mol/min)–0.36.

Conclusion: Using mathematical design of the experiment, a technology was developed for producing Ag@Fe3O4 with modern physicochemical and therapeutic requirements.

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Published

01-01-2020

How to Cite

KRYSKIV О. S., T. M. CHAN, A. O. KOVAL, O. S. SHPYCHAK, K. P. ROMAS, O. S. KRAN, T. V. MARTYNIUK, and O. V. ANTONENKO. “OPTIMIZATION OF THE TECHNOLOGY FOR PRODUCING A MAGNETO CONTROLLABLE NANOCOMPOSITE Ag@Fe3O4 USING MATHEMATICAL DESIGN”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 12, no. 1, Jan. 2020, pp. 26-30, doi:10.22159/ijpps.2020v12i1.35870.

Issue

Vol 12, Issue 1, 2020

Section

Original Article(s)
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