• ZUBERU JIBRIL BM Diagnostic Services, Kaura Namoda Zamfara State
  • SANI SANUSI Medical Services Department Federal Polytechnic Kaura Namoda Zamfara State



Bleeding time, Clotting time, Allumcepa, Haemostasis, Rats


Objective: The study investigated changes in haemostatic parameters such as; bleeding time, blood clotting time and differential platelet counts of wistar rats following repeated administration of aqueous extract of allum cepa L.

Methods: Rats were divided into four groups of four animals each (n=4). Group I served as normal control, Group II, group IIIand group IV were administered 25 mg/kg bw, 50 mg/kg bw and 100 mg/kg bw of the extract intra-peritoneally for two weeks, respectively. After 14 d experimental period, blood samples were collected for the determination of bleeding time, clotting time and differential platelet count.

Results: The findings of this study revealed a significantly increased (p<0.05) clotting time at a dose of 25 mg/kg but showed no significant change in bleeding time and differential platelet count of all the groups.

Conclusion: Aqueous extract of brown onion showed anti haemostatic effect in albino rats by increasing clotting time at a lower dose.


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How to Cite

JIBRIL, Z., and S. SANUSI. “CHANGES IN HAEMOSTATIC PARAMETERS OF WISTAR RATS FOLLOWING REPEATED ADMINISTRATION OF AQUEOUS EXTRACT OF BROWN ONION (ALLUMCEPAL.)”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 13, no. 5, May 2021, pp. 41-44, doi:10.22159/ijpps.2021v13i5.37673.



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