CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACTS OF SOLANUM ERIANTHUM D. DON
Keywords:
Solanum erianthum, Cytotoxic activity, MTT assay, Trypan blue assay, HeLa, HepG-2, MCF-7Abstract
Objective: The study was aimed to evaluate cytotoxic activity of the methanolic extracts of Solanum erianthum on HeLa, HepG-2 and MCF-7 cell lines.
Methods: The percentage viability of the cell lines were carried out using trypan blue dye exclusion method and the cytotoxicity of the extracts was evaluated by MTT assay.
Result: Solanum erianthum leaf and fruit extract showed significant cytotoxic activity on the tested cell lines with IC50 values ranging from 111.67 to 385 µg mL-1. Fruit extract showed potent cytotoxic activity on MCF-7 (IC50 111.67 µgmL-1), followed by leaf extract (IC50 150.50 µgmL-1)on HeLa cell line using MTT assay. Cell viability assay showed that fruit extract was very active on MCF-7 and leaf extract was effective against HeLa.
Conclusion: The experiment performed reveals that Solanum erianthum can be used in development of anticancer drug.
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