ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF BAMBUSA BAMBOS DRUCE AGAINST POLOXAMER-407 INDUCED HYPERLIPIDEMIA IN RATS
Keywords:
Antihyperlipidemic activity, Poloxamer-407, Bambusa bambos, AtherosclerosisAbstract
Objective: The aim of present study was to investigate a dose-dependent antihyperlipidemic effect of methanolic extract of Bambusa bambos Druce. (Family: Graminae) (MEBB) in Poloxamer-407 induced hyperlipidemia in rats at three different dose levels i. e. 100 mg/kg, 200 mg/kg and 300 mg/kg.
Methods: Animals were divided randomly into 6 groups: Group I (Vehicle Control), Group II (Disease Control), Group III (100 mg/kg MEBB), Group IV (200 mg/kg MEBB), Group V (300 mg/kg MEBB) and Group VI (Standard Control).
Results: Groups treated with the MEBB showed significant (p<0.01) decrease in serum total cholesterol, triglycerides, LDL-cholesterol VLDL-cholesterol, hepatic cholesterol and hepatic triglycerides with the concomitant increase in serum HDL-cholesterol levels. The extract also showed significant (p<0.01) antioxidant activity in liver tissue homogenate. Atherogenic indices also showed significant (p<0.05, p<0.01) decrease in treatment groups as compared to disease control group. The most effective dose was found to be 300mg/kg MEBB.
Conclusion: These results suggest that methanolic extract of Bambusa bambos leaves possess significant antihyperlipidemic activity.
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