SYNTHESIS, ANTIMICROBIAL, ANTIOXIDANT AND DOCKING STUDIES OF (3-METHOXY-5-NITROBENZOFURAN-2-YL)(PHENYL)METHANONE DERIVATIVES.SYNTHESIS, ANTIMICROBIAL, ANTIOXIDANT AND DOCKING STUDY OF (3-ALKOXY-5-NITROBENZOFURAN-2-YL) (PHENYL) METHANONE DERIVATIVES
Keywords:
(3-Alkoxy-5-nitrobenzofuran-2-yl)(phenyl) methanone, (3-hydroxy-5-nitrobenzofuran-2-yl)(phenyl) methanones, Antimicrobial activity, Antioxidant activity, Molecular docking studiesAbstract
Objective: Synthesis, antimicrobial, antioxidant and docking studies of (3-methoxy-5-nitrobenzofuran-2-yl)(phenyl)methanone derivatives (2a-j).
Methods: The products 2a-j, were obtained from different (3-hydroxy-5-nitrobenzofuran-2-yl)(phenyl)methanonesrefand alkyl bromides in the presence of K2CO3 in DMF at room temperature. Afterwards, characterised through 1H-NMR, [13]C-NMR, ESI-LCMS and elemental analyses. Finally, subjected them for antimicrobial and antioxidant studies through agar well diffusion technique and docking interaction studies through automated docking technique.
Results: From the current procedure, the compound 2a has showed the highest antibacterial activity and 2j showed lowest antibacterial activity. None of these (2a-j) have showed antifungal activity. The compound 2d has shown highest free radical scavenging activity and 2e has shown least activity. The biological properties of the synthesised compounds (2a-j) were further supported by docking studies.
Conclusion: Successfully synthesised and characterized ten individually novel (3-alkoxy-5-nitrobenzofuran-2-yl)(phenyl)methanone derivatives (2a-j) in one pot procedure and studied antimicrobial, antioxidant and docking properties. Perhaps the present work provides an evidence for the preparation, antimicrobial and antioxidant properties of the novel benzofuran derivatives.
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