COMPARISON OF PREGABALIN AND NORTRIPTYLINE ON SLEEP, QUALITY OF LIFE IN POSTHERPETIC NEURALGIA: A PROSPECTIVE, RANDOMISED, OPEN-LABEL, PARALLEL STUDY

KANIKA KHAJURIA; SEEMA GUPTA; DINESH KUMAR; DEV RAJ DOGRA; VIJAY KHAJURIA

doi:10.22159/ijpps.2021v13i6.41244

Authors

KANIKA KHAJURIA Department of Pharmacology Government Medical College Jammu (UT Jammu and Kashmir) 180001
SEEMA GUPTA Department of Pharmacology Government Medical College Jammu (UT Jammu and Kashmir) 180001
DINESH KUMAR Department of Pharmacology Government Medical College Jammu (UT Jammu and Kashmir) 180001
DEV RAJ DOGRA Department of Pharmacology Government Medical College Jammu (UT Jammu and Kashmir) 180001
VIJAY KHAJURIA Department of Pharmacology Government Medical College Jammu (UT Jammu and Kashmir) 180001

DOI:

https://doi.org/10.22159/ijpps.2021v13i6.41244

Keywords:

Postherpetic neuralgia (PHN), Pregabalin, Nortriptyline, MOS, CGIC, PGIC and EQ-5D-5L score

Abstract

Objective: Aim of the present study was to compare the effects of pregabalin and nortriptyline on sleep and quality of life in patients of postherpetic neuralgia (PHN).

Methods: The present study was conducted in 48 patients of PHN attending the outpatient department (OPD) of Dermatology, Government Medical College Jammu. Based on inclusion/exclusion criteria patients were randomized into two treatment groups. One group received pregabalin 150 mg/day and the other group was treated with nortriptyline 25 mg/day. The patients were followed up to eight weeks and assessed for Sleep (Medical Outcomes Study sleep scale) and quality of life (Euro QOL-5D-5L score). Clinicians Global Impression of Change (CGIC) score and Patient Global Impression of Change (PGIC) score were used to evaluate overall clinical improvement.

Results: Both drugs significantly improved all parameters studied (p<0.0001). On comparison, both drugs had similar effects on sleep and quality of life. However, pregabalin was found to be better than nortriptyline at eight weeks on CGIC (p<0.004) and PGIC (p<0.0003) scores.

Conclusion: Both pregabalin and nortriptyline were equally effective in improving sleep and quality of life. Overall clinical improvement was better with pregabalin than nortriptyline at eight weeks.

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