CONDUCTOMETRIC DETERMINATION OF THE ANTIHISTAMINIC DIPHENHYDRAMINE HYDROCHLORIDE USING SILVER NITRATE AS A TITRANT
Keywords:
Conductometry, Preciptimetry, AgNO3, Diphenhydramine HCl (DPH)Abstract
Objectives: The present study developed and validated a conductometric method for determination of Diphenhydramine HCl (DPH) in its pure form and in a syrup formulation using silver nitrate (AgNO3 ).
Methods: Conductometric titration method was achieved by using AgNO3. The method is built on the reaction of chloride ions coming from the DPH with AgNO3 yielding silver chloride precipitate. Conductance of the solution is measured as a function of the volume of titrant. The proposed method is linear over the range of 1-10mg.
Results: Statistical analysis of the experimental results indicates that the method is precise and accurate. The accuracy of the method is indicated by the excellent recovery and the precision is supported by the low relative standard deviation (< 0.935). The method was also applied successively to a pharmaceutical syrup formulation. The proposed method provides a high degree of accuracy and precision. Results showed that there is no significant difference between the proposed method and the reported one.
Conclusions: This proposed method is described as an alternative approach to the more complex and expensive previously reported methods for assay of DPH and is highly reproducible as compared to similar reported methods.
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References
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