LONG-TERM FOOD RESTRICTION AND DIABECON ADMINISTRATION AMELIORATES ALLOXAN-INDUCED HYPERGLYCEMIA, THYROID DYSFUNCTION, AND OXIDATIVE STRESS IN RAT.
DOI:
https://doi.org/10.22159/ijpps.2021v13i7.41522Keywords:
Food restriction, Insulin, Diabetes, Thyroid hormones, Oxidative stress, DiabeconAbstract
Objective: The comparative effects of food restriction (FR), Diabecon treatment (DT) and their combined therapy (FR+DT) were studied in the regulation of alloxan-induced diabetes mellitus, alterations in thyroid hormones (TH) and oxidative stress.
Methods: Young diabetic rats were either kept on 50% FR and/or DT (2 gm/Kg body weight) for two months and then alterations in serum glucose, insulin, TH concentrations, hepatic glycogen and pancreatic antioxidants along with oxidative stress markers were evaluated.
Results: Significantly increased serum glucose, tissue stress markers with decreased TH, hepatic glycogen (P<0.0001 for all) and pancreatic antioxidants (P<0.05-0.001) were observed in diabetic rats. Rats kept on different therapies exhibited significant (P<0.05) improvements than diabetic rats in all studied parameters. FR+DT group showed a significantly more decrease in serum glucose (P<0.05) that FR or DT group, while in other parameters improvement was found to be more or less equally improved in all treated groups.
Conclusion: FR appeared to mimic the effects of Diabecon in most of the indices. However, FR+DT appears to be more effective. Possibly both therapies ameliorate diabetes and oxidative stress following some common metabolic pathways.
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References
Sharma H, Chandola HM. Prameha in ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 2-management of Prameha. J Altern Complement Med 2011;17:589-99.
Pisarev MA. Inter-relationships between the pancreas and the thyroid. Curr Opin Endocrinol Diabetes Obes 2010;17:437-9.
Kahleova H, Matoulek M, Malinska H. Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with type 2 diabetes. Diabet Med 2011;5:549-59.
Archana D, Dixitha M, Santhy KS. Antioxidant and anti clastogenic potential of piper longum l. Inter J Appl Pharm 2015;7:11-4.
Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Rad Biol Med 2011;50:567–75.
Ajala O, English P, Pinkney. Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. J Am J Clin Nutr 2013;97:505-16.
Jain R, Jain P, Jain P. A review on treatment and prevention of diabetes mellitus. Inter J Curr Pharm Res 2016;8:16-8.
Panda S, Kar A. Periplogenin-3-O--D-glucopyranosyl (1→6)-D-glucopyaranosyl-(1→4)-D-Cymaropyranoside, isolated from Aegle marmelos protects doxorubicin-induced cardiovascular problems and hepatotoxicity in rats. Cardiovasc Ther 2009;27:108–16.
Ogbonna SU, Ezeani IU, Okafor CI, Chinenye S. Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes 2019;12:1113-22.
Mitra R, Mazumder PM, Sasmal D. Comparative evaluation of the efficacy of some ayurvedic formulations in attenuating the progression of diabetic nephropathy. Pharmacologyonline 2010;1:709-17.
Agrawal J, Kar A, Panda S. Synergistic action of phytochemicals augments their antioxidative efficacy: an in vitro comparative study. Asian J Pharm Clin Res 2013;6:121-6.
Singh J, Cumming E, Manoharan G. Medicinal chemistry of the anti-diabetic effects of momordica charantia: active constituents and modes of actions. Open Med Chem 2011;5:70-7.
Luvizotto RA, Conde SJ, Sibio MT. Administration of physiologic levels of triiodothyronine increases leptin expression in calorie-restricted obese rats, but does not influence weight loss. Metabolism 2010;59:1-6.
Gutierrez RMP, Guzman MD. Meliacinolin: a potent α-glucosidase and α-amylase inhibitor isolated from azadirachta indica leaves and in vivo antidiabetic property in streptozotocin-nicotinamide-induced type 2 diabetes in mice. J Biol Pharma Bull 2012;35:1516-2415.
Kalra S, Aggarwal S, Khandelwal D. Thyroid dysfunction and type 2 diabetes mellitus: screening strategies and implications for management. Diabetes Ther 2019;10:2035-44.
Kavitha R. Antidiabetic and enzymatic antioxidant potential from ethanolic extracts of leaf and fruit of trichosanthes dioica and leaf of clitoria ternatea on diabetic rats induced by streptozotocin. Asian J Pharm Clin Res 2018;11:233-9.
