FORMULATION AND EVALUATION OF FLOATING TABLET OF ECLIPTA ALBA EXTRACT FOR HEPATIC DISORDERS

Suresh D Sanja; Kilambi Pundarikakshudu; Moinuddin M Soniwala

Authors

Suresh D Sanja B K Mody Government Pharmacy College, Rajkot, Gujarat
Kilambi Pundarikakshudu L J Institute of Pharmacy, Ahmedabad, Gujarat
Moinuddin M Soniwala B K Mody Government Pharmacy College, Rajkot, Gujarat

Keywords:

Floating tablet, Eclipta alba, Hepatoprotective, Nil

Abstract

Objective: The aim of the present study was to design and estimate gastro retentive floating tablet of Eclipta alba extract to increase the efficacy by extending the release of extract. Eclipta alba is reported to be useful in liver ailments and has been shown to possess hepatoprotective activity.

Methods: The floating tablet extract of Eclipta alba was prepared by using kollidon SR as floating and release retarding polymer. The effect of various additive excipient was also studied and optimized using 3²full factorial design to alter the floating behaviour and extract release from the floating tablet.

Results: The polymeric structure of KollidonÂ® SR possesses appreciable porosity during the compression process. Results of multiple regression analysis show that the amount of stearic acid and lactose has significant influence on Q2, Q6 and Q10.

Conclusions: From the desirability function, the levels of the optimized batch were selected as -1 for the X1 and 1 for the X2 which correspond to batch F3 of factorial design. This study can open the avenues for the In-vitro dissolution testing of herbal extracts by simple UV method for the determination of extract release in extended release formulations.

Â

Downloads

Download data is not yet available.

Author Biographies

Suresh D Sanja, B K Mody Government Pharmacy College, Rajkot, Gujarat

Assistant Professor, Herbal Technology

Kilambi Pundarikakshudu, L J Institute of Pharmacy, Ahmedabad, Gujarat

Pharmacognosy, Director

Moinuddin M Soniwala, B K Mody Government Pharmacy College, Rajkot, Gujarat

Pharmaceutics, Associate Professor

References

Ahsan MR, Islam KM, Bulbul IJ. Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride-induced hepatotoxicity in rats. Eur J Sci Res 2009;37(2):302-10.

Kiritikar KR, Basu BD. Indian medicinal plants. 2nd ed. IK. International Pvt Ltd. Dehra Dun: International book distributors; 1999;2:1361-3.

Tuma DJ, Sorrell M. Alcohol and alcoholic liver disease. Semin Liver Dis 2004;24:215.

Handa SS, Sharma A, Chakarborty KK. Natural Products and plants as liver protecting drugs. Fitoterapia 1986;57(5):307-51.

Chopra RN, Nayar SL, Chopra IC. In: Glossary of medicinal plants, CSIR Publication, New Delhi; 1966. p. 104.

http://pathmicro.med.sc.edu/virol/hepatitis-disease. htm.

Suresh DS, Kilambi P, Moinuddin MS. Formulation and estimation of floating tablets of eclipta alba extract. Am J Adv Drug Delivery 2014;2(2):280-90.

Prasant KR, Bhabani SN. Statistical evaluation of losartan microspheres prepared by w/o emulsion method using factorial design and response surface methodology. Asian J Pharm Clin Res 2009;2(4):39-46.

Sanjay SP, Natvarlal MP. Development of directly compressible co-processed excipient for dispersible tablets using 32full factorial design. Int J Pharm Pharm Sci 2009;1(1):125-48.

Kumar V, Damien B, Potdar AR. Designing of stability programme. Eastern Pharm 1992;35(416):29-32.