• T. K. SUBAIR College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode 673008, India
  • JISHA MOHANAN College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode 673008, India



Film forming gel, Nanoparticle, Solvent evaporation method, Luliconazole, Ethylcellulose, Polyvinyl pyrrolidone, Polyvinyl alcohol


Objective: Luliconazole (LZL) has low aqueous solubility that limits its dermal bioavailability and acts as a barrier to topical delivery. The conventional topical formulations have a limited ability to retain the drug over the skin for a prolonged period. The main objective of the study was to formulate and characterize LZL loaded ethyl cellulose (EC) nanoparticles and formulate them as a film-forming gel (FFG) for prolonged delivery in fungal skin infections.
Methods: The solvent evaporation technique was used for the preparation of nanoparticles of LZL by using EC as a polymer. The prepared nanoparticles were evaluated for physical appearance, production yield, entrapment efficiency, drug content, particle size, zeta potential, Polydispersity index (PDI), and in vitro drug release. Then the nanoparticles were incorporated into FFG formulation by using polyvinyl pyrrolidone (PVP) and polyvinyl alcohol (PVA) as the gelling agent. The prepared FFG was evaluated for pH, Viscosity, Spreadability, in vitro drug release studies, in vitro antifungal studies, and release kinetic studies.
Results: The optimized nanoparticle formulation F5 having drug to polymer ratio of 1:2 showed satisfactory production yield (86.32%), entrapment efficiency (83.36%), drug content (42.86), particle size (125.3), and 93.72% of in vitro drug release after 24 h (h). The optimized FFG formulation FFG4 showed the shortest film-forming time of 5.06 min (min), percentage Cumulative drug release of 92.18% after 24 h, and had promising in vitro antifungal activity.
Conclusion: The prepared FFG could be used with promising potential for fungal infection of the skin.


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Kumar M, Shanthi N, Mahato AK, Soni S, Rajnikanth PS. Preparation of luliconazole nanocrystals loaded hydrogel for improvement of dissolution and antifungal activity. Heliyon. 2019 May 1;5(5):e01688. doi: 10.1016/j.heliyon.2019.e01688, PMID 31193099.

Kyle AA, Dahl MV. Topical therapy for fungal infections. Am J Clin Dermatol. 2004 Dec;5(6):443-51. doi: 10.2165/00128071-200405060-00009, PMID 15663341.

Kathe K, Kathpalia H. Film-forming systems for topical and transdermal drug delivery. Asian J Pharm Sci. 2017 Nov 1;12(6):487-97. doi: 10.1016/j.ajps.2017.07.004, PMID 32104362.

Yadav SA, Poddar SS. Formulation, in vitro and in vivo evaluation of nanoemulsion gel for transdermal drug delivery of nimodipine. Asian J Pharm Clin Res. 2015 Mar 1:119-24.

Attia MA, El Badawy HY. Film-forming gel for the treatment of oral mucositis: in vitro studies. Int J Drug Delivery. 2010 Oct 1;2(4):314-21. doi: 10.5138/ijdd.2010.0975.0215.02043.

Shaikh AN, Pawar AY. Formulation and evaluation of nanosponges loaded hydrogel of luliconazole. Int J Sci Dev Res. 2020;5:215-27.

Saudagar RB. Formulation, development and evaluation of film-forming gel for prolonged dermal delivery of terbinafine hydrochloride. Int J Pharm Sci Res. 2014;5:537-4.

Moin A, Deb TK, Osmani RA, Bhosale RR, Hani U. Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy. J Basic Clin Pharm. 2016 Mar;7(2):39-48. doi: 10.4103/0976-0105.177705, PMID 27057125.

Kapileshwari GR, Barve AR, Kumar L, Bhide PJ, Joshi M, Shirodkar RK. Novel drug delivery system of luliconazole- formulation and characterization. J Drug Deliv Sci Technol. 2020 Feb 1;55. doi: 10.1016/j.jddst.2019.101302, PMID 101302.

Kreuter J. Nanoparticle-based dmg delivery systems. J Control Release. 1991 Jun 1;16(1-2):169-76. doi: 10.1016/0168-3659(91)90040-K.

Khasraghi AH, Thomas LM. Preparation and evaluation of lornoxicam film-forming gel. Drug Invent Today. 2019 Aug 1;11(8).

Tran TTD, Tran PHL. Controlled release film-forming systems in drug delivery: the potential for efficient drug delivery. Pharmaceutics. 2019 Jun;11(6):290. doi: 10.3390/pharmaceutics11060290, PMID 31226748.

Wadile KA, Ige PP, Sonawane RO. Preparation of itraconazole nanoparticles and its topical nanogel: physicochemical properties and stability studies. Int J Pharm Sci Dev Res. 2019 Jan 3;5(1):1-8.

Saudagar RB, Gangurde PA. Formulation, development and evaluation of film-forming gel for prolonged dermal delivery of miconazole nitrate. Res J Top Cosmet Sci. 2017;8(1):19-29. doi: 10.5958/2321-5844.2017.00003.6.

Ngo HV, Tran PHL, Lee BJ, Tran TTD. Development of film-forming gel containing nanoparticles for transdermal drug delivery. Nanotechnology. 2019 Jul 25;30(41):415102. doi: 10.1088/1361-6528/ab2e29.

Hina KS, Kshirsagar RV, Patil SG. Mathematical models for drug release characterization: a review. World J Pharm Pharm Sci. 2015;4(4):324-38.

Ramteke KH, Dighe PA, Kharat AR, Patil SV. Mathematical models of drug dissolution: a review. Scholars Acad J Pharm. 2014;3(5):388-96.

Wang YB, Lian ZX, Chen MN, Zhang L, Zhou CY, Wei W. Bioadhesive drug delivery system of diltiazem hydrochloride for improved bioavailability in cardiac therapy. Trop J Pharm Res. 2016;15(7):1375-80. doi: 10.4314/tjpr.v15i7.4.



How to Cite

SUBAIR, T. K., and J. MOHANAN. “DEVELOPMENT OF NANO BASED FILM FORMING GEL FOR PROLONGED DERMAL DELIVERY OF LULICONAZOLE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 14, no. 2, Feb. 2022, pp. 31-41, doi:10.22159/ijpps.2022v14i2.43253.



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