• Leila Beyi Mohammed the First University, Oujda, Morocco
  • Mohammed Aziz Mohammed the First University
  • Hanane Makrane Mohammed the First University
  • Ahmed Karim Mohammed the First University
  • Mohammed Bnouham Mohammed the First University
  • Abderrahim Ziyyat Mohammed the First University


Thymus algeriensis, Antidiarrheal activity, Castor oil, Intestinal transit


Objective: Thymus algeriensis (Lamiaceae) used in Moroccan popular medicine has been investigated for its antidiarrheal effects.

Methods: Antidiarrheal effects of the aerial-part Thymus algeriensis aqueous extract was carried out by using two standard methods of bioassay: Castor oil-induced diarrhea and gastrointestinal transit test.

Results: The pre-treatment of rats with the 50 mg/Kg aqueous extract produced a significant inhibition against castor oil induced-diarrhea and fecal output; furthermore the extract significantly decreased the propulsive movement of the charcoal meal in the mice small intestines. The extract when administered at higher doses (100 and 200 mg/kg) caused increased peristalsis in charcoal fed animals and exhibited a less significant reduction in fecal output and castor oil-induced diarrheas than 50 mg/ml dose.

Conclusion: The antidiarrheal effects of the extract may explain the rationale for the use of the plant in traditional medicine as a popular antidiarrheal recipe.



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How to Cite

Beyi, L., M. Aziz, H. Makrane, A. Karim, M. Bnouham, and A. Ziyyat. “ANTIDIARRHEAL ACTIVITY OF THYMUS ALGERIENSIS BOISS AND REUT AQUEOUS EXTRACT ON RATS AND MICE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 292-4,



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