TOXICOLOGICAL TESTING OF BARKS FROM CROTON RHAMNIFOLIOIDES (EUPHORBIACEAE)

Authors

  • Izabela Rangel Lima Universidade Federal de Pernambuco
  • Ivanise Brito Da Silva Universidade Federal de Pernambuco
  • Mardonny Bruno De Oliveira Chagas Universidade Federal de Pernambuco
  • Roberta Maria Pereira Leite Universidade Federal de Pernambuco
  • Maria Bernadete De Sousa Maia Universidade Federal de Pernambuco
  • SÔnia Pereira Leite Universidade Federal De Pernambuco

Keywords:

Croton rhamnifolioides, Medicinal plants, Phytochemical, Toxicity

Abstract

Objective: The present study aimed to study the phytochemical screening of stem bark of C. rhamnifolioides and evaluate the toxicological potential of Artemia salina.

Methods: Barks were subjected to methanol extraction at room temperature and, subsequently, a preliminary phytochemical study was conducted. The methanol extract at concentrations of 500, 250 and 125 mg/ml was investigated in the toxicological study through the A. salina method.

Results: The phytochemical screening showed the presence of secondary metabolites: alkaloids, triterpenes and flavonoids. The methanol extract showed a LC50 of 486.59 µg/ml, with a moderate toxicity, in which viable LC50 were 27.5, 82.5 and 100%, respectively.

Conclusion: This study may contribute to the knowledge of this species' toxicity, inform the public on the proper use of herbal and natural medicines and assist in the cataloging of information on plants used in popular medicine.

 

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Author Biographies

Izabela Rangel Lima, Universidade Federal de Pernambuco

Cell Culture Laboratory, Department of Histology and Embryology, Federal University of Pernambuco, Brazil

Ivanise Brito Da Silva, Universidade Federal de Pernambuco

Cell Culture Laboratory, Department of Histology and Embryology, Federal University of Pernambuco, Brazil

Mardonny Bruno De Oliveira Chagas, Universidade Federal de Pernambuco

Immunomodulation Laboratory and New Therapeutic Approaches, Center for Research in Innovation Therapy Suely Galdino, Federal University of Pernambuco, Brazil.

Roberta Maria Pereira Leite, Universidade Federal de Pernambuco

Cell Culture Laboratory, Department of Histology and Embryology, Federal University of Pernambuco, Brazil

Maria Bernadete De Sousa Maia, Universidade Federal de Pernambuco

Laboratory of Bioactive Products, Department of Physiology and Pharmacology, Federal University of Pernambuco, Brazil.

SÔnia Pereira Leite, Universidade Federal De Pernambuco

Cell Culture Laboratory, Department of Histology and Embryology, Federal University of Pernambuco, Brazil

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Published

01-04-2015

How to Cite

Lima, I. R., I. B. D. Silva, M. B. D. Oliveira Chagas, R. M. Pereira Leite, M. B. De Sousa Maia, and S. P. Leite. “TOXICOLOGICAL TESTING OF BARKS FROM CROTON RHAMNIFOLIOIDES (EUPHORBIACEAE)”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 4, Apr. 2015, pp. 408-10, https://journals.innovareacademics.in/index.php/ijpps/article/view/4411.

Issue

Vol 7, Issue 4, 2015

Section

Short Communication(s)

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