IN-VIVO ANTI-PYRETIC, ANTI-NOCICEPTIVE, NEUROPHARMACOLOGICAL ACTIVITIES AND ACUTE TOXICITY INVESTIGATIONS OF BLUMEA LACERA

Authors

  • Farzana Akhter Fancy Phytochemistry Research Laboratory, Department of Pharmacy University of Asia Pacific, Dhaka, Bangladesh.
  • Mohammad Shahriar Phytochemistry Research Laboratory, Department of Pharmacy University of Asia Pacific, Dhaka, Bangladesh.
  • Md Reazul Islam University of Asia Pacific
  • Mohiuddin Ahmed Bhuiyan University of Asia Pacific

Keywords:

Blumea lacera, In-vivo antipyretic activities, Anti-nociceptive activity, Neuropharmacological activities, Acute toxicity

Abstract

Objective: The present study was done to evaluate in vivo anti-pyretic, neuropharmacological activity including open field and swimming test, gastrointestinal motility, anti-nociceptive and acute toxicity effect of different leaf extracts of Blumea lacera in Swiss albino mice following oral administration.

Methods: In-vivo antipyretic test of methanol, ethanol and chloroform extracts of Blumea lacera leaf was done brewer's yeast method; neuropharmacological study was performed by open field test and swimming test, GI motility test was done by charcoal induced anti motility test, anti-nociceptive activity was tested by acetic acid induced writhing method and acute toxicity study was done by investigating mortality/morbidity status of test animal.

Results: In-vivo antipyretic activity shows methanol extracts at a dose of 400 mg/kg b. w., both the doses of ethanol extract and chloroform extract at a dose of 200 mg/kg b. w. produced significant (p<0.05) reduction of temperature in mice comparing to the standard drug diclofenac Na. In-vivo neuropharmacological activity study yields significant results when methanol 100 mg/kg, ethanol 200 mg/kg, chloroform 100 & 200 mg/kg extracts were administered to evaluate the rate of movement with time in a dose dependent manner when compared with the corresponding value of control group. In gastrointestinal motility test methanol extract at 250 mg/kg, ethanol extract at 250 & 500 mg/kg and chloroform 250 mg/kg doses significantly reduce GI motility when compared to standard drug loperamide. Statistically significant (p <0.001, p<0.02, p<0.05) results were found in in-vivo anti-nociceptive activity test for the 100 mg/kg chloroform, 100 mg/kg methanol and 200 mg/kg ethanol respectively when compared to standard diclofenac-Na. None of the extracts showed any significant in-vivo acute toxicity effect on mice.

Conclusion: This plants leaf extracts exhibit potent antipyretic acitivities; significant neuropharmacological activities and significant anti-nociceptive activity without inducing any discernible acute toxicity effect.

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Published

01-01-2015

How to Cite

Fancy, F. A., M. Shahriar, M. R. Islam, and M. A. Bhuiyan. “IN-VIVO ANTI-PYRETIC, ANTI-NOCICEPTIVE, NEUROPHARMACOLOGICAL ACTIVITIES AND ACUTE TOXICITY INVESTIGATIONS OF BLUMEA LACERA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 1, Jan. 2015, pp. 472-7, https://journals.innovareacademics.in/index.php/ijpps/article/view/4495.

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