FORMULATION AND EVALUATION OF ION-SENSITIVE IN-SITU NASAL GEL OF ZOLMITRIPTAN
Keywords:
In situ gelling, Nasal delivery, Migraine, Polymers, Sustained release, Higher bioavailability etcAbstract
In situ gel system is novel drug delivery system in which there is the transition of sol to gel on external stimuli like change in pH, temperature or change in ion concentration(sol-gel transition). In the present study various formulations were prepared by using gellan gum as gelling agent and HPMC K100 as controlled or sustained release polymer. All the formulations were evaluated for various parameters like pH, viscosity, drug content, gel strength, mucoadhesive strength and drug release. At minimum concentration of polymer lose their integrity and at maximum concentration stiff gel were formed. At optimized concentration of gelling agent and HPMC K100 showed in situ gelling with all parameter in range. In vitro release data revealed that the optimized formulation showed controlled and sustained drug release pattern. The optimized formulation also obeyed korsmer Peppas model equation and which showed the release exponent n value 0.765. Thus, the ex vivo higher bioavailability can be expected from the optimized formulation.
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