THE EFFECT OF HANDING MERCURY DROP ELECTRODE ON DIFFERENTIAL PULSE POLAROGRAPHIC BEHAVIOR AND DETERMINATION OF ROSUVASTATIN IN PURE AND PHARMACEUTICAL TABLETS

Authors

  • Abdul Azizs Ramadan Aleppo University
  • Hasna Mandil Aleppo University
  • Nour Ghazal Aleppo University

Keywords:

Differential pulse polarographic method, Handing mercury drop electrode, Rosuvastatin, Pharmaceutical tablets

Abstract

Objective: Developing a simple, accurate and very sensitive differential pulse polarographic method (DPPM) for determination of rosuvastatin (RSV) in pure and tablets dosage forms using handing mercury drop electrode (HMDE).

Methods: The DPPM was applied in Na2HPO4 buffer at pH 1.5 using a HMDE in optimal conditions.

Results: One redaction peak was observed in the range -929 to -940 mV (Ep). The peak current Ip is linear over the ranges 0.9631-192.61 ng. mL-1; Which led to increase the sensitivity about ten and hundred times when using SMDE and DME, respectively. The relative standard deviation did not exceed 3.6% and regression analysis showed a good correlation coefficient (R2= 0.9998). The limit of detection (LOD) and the limit of quantification (LOQ) were to be 0.112 and 0.34 ng. mL-1, respectively. The amounts of RSV in different tablet dosage forms were decreases with the time (1.1-1.7% after six months at the end of the validity period).

Conclusion: The proposed method was successfully applied to determine very small amounts of RSV (0.9631 ng. mL-1) in pure form and in pharmaceutical tablets.

 

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References

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Published

01-03-2015

How to Cite

Ramadan, A. A., H. Mandil, and N. Ghazal. “THE EFFECT OF HANDING MERCURY DROP ELECTRODE ON DIFFERENTIAL PULSE POLAROGRAPHIC BEHAVIOR AND DETERMINATION OF ROSUVASTATIN IN PURE AND PHARMACEUTICAL TABLETS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 300-7, https://journals.innovareacademics.in/index.php/ijpps/article/view/4509.

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