INVESTIGATIONS ON NOVEL BIO-BINDER ISOLATED FROM AEGLE MARMELOS USED IN IBUPROFEN TABLETS
Keywords:
Ibuprofen, Aegle marmelos gum, Binder, Drug releaseAbstract
Objective: Binders are agents used to impart cohesive qualities to the powdered material during the production of tablets. Thus the aim of present research work was to formulate the oral tablets of Ibuprofen by using Aegle marmelos fruit gum as a binder.
Methods: In this study oral tablets of ibuprofen were formulated by using aegle marmelos fruit gum as a binder. Granules of ibuprofen were prepared by using binder solution of gum in the concentrations 2, 4, 6, 8 and 10 %. The tablets were compressed by using the single punch tablet machine and the prepared tablets were evaluated.
Results: All the evaluation parameters were found to be within the Pharmacopoeial limits at binder concentration 6-8 %. Drug release from tablets decreased with increase in binder concentration and tablets containing binder concentration of 6 % shows more optimum results.
Conclusion: Thus the Aegle marmelos gum was found to be useful for the preparation of uncoated tablet dosage form.
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References
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