FORMULATION DEVELOPMENT AND CHARACTERIZATION OF LAFUTIDINE RAFT SYSTEM
DOI:
https://doi.org/10.22159/ijpps.2023v15i4.47068Keywords:
In situ gel, Lafutidine, Raft, Floating, Controlled releaseAbstract
Objective: The present research work is focused to develop in situ raft gel of lafutidine. Sodium alginate is one of the critical components for the development in situ raft system.
Methods: The formulation was prepared using hydrophilic polymers such as ethyl cellulose, HPMC K4M, and chitosan. The formulations were subjected to evaluation characteristics such as pH, in vitro gelling time, viscosity, density, gel strength, drug-polymer compatibility studies, drug content floating lag time, swelling index, and in vitro release studies.
Results: The pH of all the prepared batches was found in the range of 5.7 to 7.6. All the prepared formulations showed viscosity in the range of 264 to 320 cps, with gelling time from 4-7 s. For F1-F15 batches Floating lag time was found to be in the range of 9-24 sec. Densities of all formulations stomach specific in situ gels were in the range of 0.4 to 0.8 gm/cm3. The highest swelling index was observed in F15 with 14.16% Highest gel strength is exhibited by F15; all the formulations were in the range of 95.46–99.95, indicating the uniform distribution of the drug. Formulation F15 containing chitosan in combination with ethyl cellulose gave the highest drug release of 99.78% and also showed sustained and controlled release for up to 24h.
Conclusion: F15 shows an R2 value of 0.999. As its value is nearer to the ‘1’ it is confirmed as it follows the Zero order release with an ‘n’ value is 1.5021 for the optimized formulation (F15) i.e., the n value indicates super case II transport and is considered as optimized formulation.
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Teaima M, Abdelmonem R, Saady M, El-nabarawi M, Shoman NA. Comprehensive overview on recent updates of gastroretentive raft-forming systems. Int J App Pharm. 2022;14(3):40-8. doi: 10.22159/ijap.2022v14i3.44098.
Prajapati VD, Jani GK, Khutliwala TA, Zala BS. Raft forming system-An upcoming approach of gastroretentive drug delivery system. J Control Release. 2013;168(2):151-65. doi: 10.1016/j.jconrel.2013.02.028, PMID 23500062.
Dawood NM, Abdal-hammid SN, Hussien AA. Formulation and characterization of lafutidine nanosuspension for oral drug delivery system. Int J App Pharm. 2018;10(2):20-30. doi: 10.22159/ijap.2018v10i2.23075.
Srinivas L, sagar S. Design, optimization, and evaluation of raft forming gastro retentive drug delivery system of lafutidine using box–Behnken design. Int J App Pharm. 2022;14(1):266-74. doi: 10.22159/ijap.2022v14i1.43358.
Kumar R, Chandra A, Gupta S, Gautam PK. Development and validation of uv spectrophotometric method for quantitative estimation of lafutidine in bulk and pharmaceutical dosage form. Int J App Pharm. 2017;9(6):75-9. doi: 10.22159/ijap.2017v9i6.21943.
Jabir SA, Sulaiman HT. Preparation and characterization of lafutidine as an immediate-release oral strip using a different type of water-soluble polymer. Int J App Pharm. 2018;10(5):249-60. doi: 10.22159/ijap.2018v10i5.28292.
Patil S, Talele GS. Gastroretentive mucoadhesive tablet of lafutidine for controlled release and enhanced bioavailability. Drug Deliv. 2015;22(3):312-9. doi: 10.3109/ 10717544.2013.877099, PMID 24471787.
Patel MD, Patel DG, Patel NC. Formulation and optimization of raft-forming chewable tablet containing lafutidine. Int J Pharm Sci Drug Res. 2015;7(3):229-34.
M SS, Priya S, Maxwell A. Formulation and evaluation of novel in situ gel of lafutidine for gastro retentive drug delivery. Asian J Pharm Clin Res. 2018 Aug;11(8):88-94. doi: 10.22159/ajpcr.2018.v11i8.25582.
Soni A, Mahesh Kumar Kataria. Formulation and evaluation of floating in situ gel of omeprazole magnesium for oral drug delivery system. Asian J Pharm Clin Res 2021;14(9):44-52. doi: 10.22159/ajpcr.2021.v14i9.42231.
Sagar S, Srinivas L. Development and evaluation of raft forming gastro retentive floating drug delivery system of nizatidine by the design of experiment. Int J App Pharm. 2022;14(2):242-51. doi: 10.22159/ijap.2022v14i2.43728.
Abbas G, Hanif M, Khan MA. pH-responsive alginate polymeric rafts for controlled drug release by using box Behnken response surface design. Des Monomers Polym. 2017;20(1):1-9. doi: 10.1080/15685551.2016.1231046, PMID 29491774.
Sathiyaraj S, Devi RD, Hari VB. Lornoxicam gastro retentive floating matrix tablets: design and in vitro evaluation. J Adv Pharm Technol Res. 2011;2(3):156-62. doi: 10.4103/2231-4040.85531, PMID 22171312.
Padmasri B, Nagaraju R. Formulation and evaluation of novel in situ gel system in the management of rheumatoid arthritis. Int J Appl Pharm. 2022 Sep 7;14(5):62-8.
Gadad AP, Naik SS, Dandagi PM, Bolmal UB. Formulation and evaluation of gastroretentive floating microspheres of lafutidine. Ind J Pharm Educ Res. 2016;50(2):76-81.
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