GENUS LEPIDAGATHIS (ACANTHACEAE): REVIEW OF ITS ETHANOBOTANY, PHYTOCHEMISTRY AND PHARMACOLOGICAL POTENTIAL

Authors

  • SUTHA PONNUSAMY The Tamil Nadu Dr M. G. R Medical University, Guindy, Chennai-600032, TN, India https://orcid.org/0000-0001-5809-4765
  • SANGAMESWARAN BALAKRISHNAN HOD Department of Pharmacognosy, SSM College of Pharmacy, Erode-638312, TN, India

DOI:

https://doi.org/10.22159/ijpps.2023v15i5.47280

Keywords:

Acanthaceae, Pharmacology, Phytochemistry

Abstract

Almost all societies have employed medicinal plants as a source of medicine. Due to their natural origin, low cost, and lack of side effects, traditional medicinal plants have become increasingly popular over the past few decades. The Vedas and the Bible both mention the common usage of herbal medicines and healthcare products. People have used medicinal plants for thousands of years to flavour and preserve food, cure health problems, and prevent disease. Acanthaceae plant species are valued for their cultural and economic significance in horticulture and traditional medicine worldwide due to their wide range of medicinal characteristics. It was discovered that 87% of therapeutic drugs were made from naturally occurring substances taken from plants. In addition to being utilized as food, medicine, or ornamentals, plant species in this family also contain a variety of vital secondary metabolites, such as alkaloids, terpenoids, tannins, quinones, and flavonoids. The ethnopharmacological drugs of this class are utilised in many South and East Asian countries. According to some studies, Acanthaceae may possess antiviral, antifungal, cytotoxic, anti-inflammatory, antipyretic, hepatoprotective, immunomodulatory, and antiplatelet aggregation properties. The current review identifies some salient traits of a few significant genera in this family and explores how they are used in both traditional and creative ways in modern society. By keeping these factors in mind, the current study will be helpful for future research and clinical trials in the study of some new significant plant species that belong to this significant family.

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References

Correa GM, Alcantara AFde C. Chemical constituents and biological activities of species of Justicia: a review. Rev Bras Farmacogn. 2012 Feb;22(1):220-38. doi: 10.1590/S0102-695X2011005000196.

Jan SA, Shinwari ZK, Zeb A, Khalil AT, Shah SH. Ethnobotany and research trends in Trachyspermumammi L. (Ajowan); a popular folklore remedy. Am Eurasian J Agric Environ Sci. 2015;15(1):68-73. doi: 10.5829/idosi.aejaes.2015.15.1.1249.

Gurib Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med. 2006;27(1):1-93. doi: 10.1016/j.mam.2005.07.008. PMID 16105678.

Kamboj A. Analytical evaluation of herbal drugs. Drug discovery research in pharmacognosy. Intech; Mar 2012. doi: 10.5772/26109.

Inoue M, Craker LE. Medicinal and aromatic plants-uses and functions. Hortic Plants People Places Neth Pharmacog Plants. Feb 2019:645-69. doi: 10.5772/intechopen.82497.

Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States. Vol. 12. National Institutes of Health: CDC National Health Statistics Reports; Dec 2008. p. 1-23.

Oh HJ, Park JE, Park YG, Jeong BR. Growth and quality of plug seedlings of three indigenous medicinal plants as affected by ionic strength of the nutrient solution. Hortic Environ Biotechnol. 2014;55(2):63-9. doi: 10.1007/s13580-014-0074-x.

Singh V, Kumar R. Study of phytochemical analysis and antioxidant activity of Allium sativum of Bundelkhand region. IJLSSR. 2017;3(6):1451-8. doi: 10.21276/ijlssr.2017.3.6.4.

Bamola N, Verma P, Negi C. A review on some traditional medicinal plants. IJLSSR. 2018;4(1):1550-6. doi: 10.21276/IJLSSR.2018.4.1.7.

Dar RA, Shahnawaz M, Qazi PH. General overview of medicinal plants: a review. J Phytopharmacol. 2017;6(6):349-51. doi: 10.31254/phyto.2017.6608.

Komalavalli T, PackiaLincy MS, Mohan VR. Anticancer activity of ethanol extract of Asystasia travancorica Bedd. (Acanthaceae) whole plant against dalton ascites lymphoma. J Adv Pharm Edu Res Jun. 2014;4(2):240-6.

Desai AG, Qazi GN, Ganju RK, El-Tamer M, Singh J, Saxena AK. Medicinal plants and cancer chemoprevention. Curr Drug Metab. 2008;9(7):581-91. doi: 10.2174/138920008785821657, PMID 18781909.

Wang H, Khor TO, Shu L, Su ZY, Fuentes F, Lee JH. Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem. 2012;12(10):1281-305. doi: 10.2174/187152012803833026. PMID 22583408.

Halder S, Modak P, Sarkar BK, Das A, Sarkar AP, Chowdhury AR. Traditionally used medicinal plants with anticancer effect: a review. Int J Pharm Sci Rev Res. 2020 Dec;65(1):1-13. doi: 10.47583/ijpsrr.2020.v65i01.001

Kooti Wesam, Servatyari Karo, Behzadifar M, Asadi Samani M, Sadeghi F, Nouri Bijan. Effective medicinal plant in cancer treatment, Part 2: Review study. J Evid Based Complementary Altern Med. 2017;22(4):982-95. doi: 10.1177/2156587217696927, PMID 28359161.

Gangaram S, Naidoo Y, Dewir YH, El-Hendawy S. Phytochemicals and biological activities of Barleria (Acanthaceae). Plants (Basel). 2021;11(1):82. doi: 10.3390/plants11010082, PMID 35009086.

Jan SA. Ethnobotany and medicinal uses of folklore medicinal plants belonging to family acanthaceae: an updated review. MOJBM 2017;1(2). doi: 10.15406/mojbm.2017.01.00009.

Jafarinia M. A review of medicinal properties of some asteraceae family plants on immune system. Rep Health Care. 2019 Jun;5(2):1-8.

Jain SK, De Filipps RA. Medicinal plants of India Inc. reference. Publications. 2008;116(2):370-6.

Hussain M, Ghani A. Herbal remidies used for gastrointestinal disorders in Kaghan valley NWFP. Pakistan Pak J Weed Sci Res. 2008;14(3-4):169-200.

Maurya S, Singh D. Quantitative analysis of total phenolic content in Adhatoda vasica nees extracts. Int J PharmTech Res. 2010 Dec;2(4):2403-6.

Ayyanar M, Ignacimuthu S. Medicinal uses and pharmacological actions of five commonly used Indian medicinal plants: a mini-review. Iran J Pharmacol Ther. Jun 2008;7(1):107-14.

Day SH, Lin YC, Tsai ML, Tsao LT, Ko HH, Chung MI. Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. J Nat Prod. 2002;65(3):379-81. doi: 10.1021/np0101651, PMID 11908984.

Afzal K, Uzair M, Chaudhary BA, Ahmad A, Afzal S, Saadullah M. Genus Ruellia: pharmacological and phytochemical importance in ethnopharmacology. Acta Pol Pharm. 2015;72(5):821-7. PMID 26665388.

Freyre R, Moseley A, Wilson SB, Knox GW. Breeding and evaluating for landscape performance and fruitlessness in Mexican petunia (Ruellia, Acanthaceae). Horts. 2012;47(9):1245-51. doi: 10.21273/HORTSCI.47.9.1245.

Miranda AS, Vieira M. Production of floral morphs in Cleistogamous Ruellia brevifolia (Pohl) C. Ezcurra (Acanthaceae) at different levels of water availability. J Poll Ecol Nov. 2016;19(15):104-7.

Wangia CO, Orwa JA, Muregi FW, Kareru PG, Cheruiyot K, Guantai E. Quantitative and fourier transform infrared analysis of saponins from three Kenyan Ruellia species: Ruellia prostrata, Ruellia lineari-bracteolata and Ruellia bignoniiflora. Int J Bio Eco Eng. 2018 Dec;12(6):155-9.

Afzal MK, Uzair M, Chaudhry BA. Anticancer activity of Ruellia squarrosa against human prostate cancer cell line. Bangladesh J Pharmacol. Jan 2015;10(1):97-9. doi: 10.3329/bjp.v10i1.21211.

Dey S, Roy S, Deb N, Sen KK, Besra SE. Anticarcinogenic activity of Ruellia tuberosa L. (Acanthaceae) leaf extract on hepatoma cell line and increased superoxide dismutase activity on macrophage cell lysate. Int J Pharm Pharm Sci. 2013 Jan;5(3):854-61.

Jagtap TD, Shirsat RP, Koche DK. Updates on ethnomedicinal uses and biological activities of genus Ruellia. Int J Pharmacogn Phytochem Res. 2022 Sep;14(3):19-23.

Cheonga BE, Zulkarnain Waslimb Mohd, Fui Fui Lema PLT. Antioxidant and antiproliferative activities of sabah Ruellia tuberosa. J Appl Pharm Sci. 2013 Dec;3(12):20-4. doi: 10.7324/JAPS.2013.31204.

Safitri A, Roosdiana A, Rosyada I, Evindasari CA, Muzayyana Z, Rachmawanti R. Phytochemicals screening and antioxidant activity of hydroethanolic extracts of Ruellia tuberosa L. IOP Conf Ser.: Mater Sci Eng. 2019;509:012-7. doi: 10.1088/1757-899X/509/1/012017.

Shendage SM, Yadav SR. Revision of the genus Barleria (Acanthaceae) in India. J Ind Asso Angiosperm Tax. 2010 Dec;20(2):81-130. doi: 10.22244/rheedea.2010.20.02.04.

Panchal P Kumari, Meena SK, Singh K, Sharma N. Anticancer and antimicrobial potential of Barleria prionitis leaves ethanol extract. Int J Pharm Pharm Sci. 2018;10(10):100-3. doi: 10.22159/ijpps.2018v10i10.27967.

Ghosh S. Novel anticancer platinum and palladium nanoparticles from barleria prionitis. GJN 2017;2(5). doi: 10.19080/GJN.2017.02.555600.

Baskaran A, Karthikeyan V, Sebastianrajasekaran C. Enhanced anticancer activity of Barleria longifloral. F in human cervical cancer (Hela) cells. Int J Life Sci Res Mar. 2019;7(1):230-3.

Poornima M, Jacob A, AjithBabu T. K, Malavika T. M, Lepidagathis Keralensis: An overview. Int J Res and Sci Innov. Jul2021;8(7):25-7.

Dhanalakshmi M, Thangadurai S. Antioxidant and anticancer activities of whole plant extracts of Lepidagathis pungens nees: in vitro evaluation. Phcog Mag. 2021;17(5). doi: 10.4103/pm.pm_356_20.

Abubacker MN, Kamala Devi P. Lepidagathis cristata willed. (Acanthaceae): A review of its phytochemical and pharmacology activities. Med Res Arch. May2017;5(5):1-8.

Reddy PA, Rao JV. A review of lepidagathis cristata. Int Res J Pharm 2013;4(11):6-8. doi: 10.7897/2230-8407.041102.

Ravikanth V, Niranjan Reddy VL, Ramesh P, Prabhakar Rao T, Diwan PV, Khar A. An immunosuppressive tryptophan-derived alkaloid from Lepidagathis cristata. Phytochemistry. 2001;58(8):1263-6. doi: 10.1016/s0031-9422(01)00383-1, PMID 11738419.

https://efloraofindia.com [Last accessed on 03 Apr 2023]

Yadava RN. A new biologically active triterpenoid saponin from the leaves of lepidagathis hyalina nees. Nat Prod Lett. 2001;15(5):315-22. doi: 10.1080/10575630108041298, PMID 11841115.

Islam S, Fahad FI, Sultana A, Sayem SAJ, Roy SB, Islam MN. Evaluation of antioxidant, cytotoxic, anti-inflammatory, antiarthritic, thrombolytic, and anthelmintic activity of methanol extract of lepidagathis hyalina nees root. Evid Based Complement Alternat Med. 2022;2022:2515260. doi: 10.1155/2022/2515260. PMID 35211179.

Raja P, Dhatchanamoorthy N, Soosairaj S, Jansirani P. New distribution record of two endemic plant species, Euphorbia kadapensis Sarojin. and R. R. V. Raju (Euphorbiaceae) and Lepidagathis keralensis Madhus. & N. P. Singh (Acanthaceae), for Karnataka, India. J Threat Taxa 2020;12(14):17045-8. doi: 10.11609/jott.4978.12.14.17045-17048.

Leena Palakkal NH, Hukuman Z, Mullappally Jisha. Antioxidant activities and chemical composition of various crude extracts of Lepidagathis keralensis. J App Pharm Sci. 2017;7(6):182-9. doi: 10.7324/JAPS.2017.70626.

http://www.worldfloraonline.org. [Last accessed 03 Apr 2023]

Rattan R, Kumari A, Gautam V, Fozdar BI, Sharma U. Preliminary phytochemical screening, antioxidant and antifungal activity of Lepidagathis cuspidate. Int J Drug Dev Res Mar. 2016;8(1):001-3.

Babre NP, Shivraj Gouda T, Gowrishankar NL. Phytochemical and in vitro antioxidant evaluation of methanolic and aqueous extract of Lepidagathis cuspidate. Int J Biomed and Adv Res Nov. 2017;8(11):431-6. doi: 10.7439/ijbar.v8i11.4516.

Manoharan Dhanalakshmi S, Ananda T. Evaluation of anticancer effect of ehanolic extract of Lepidagathis pungens nees whole plant by MTT assay-an in vitro study. Eur J Mol Clin Med. 2020;7(8):1027-38. doi: 10.26452/ijrps.v11i4.3614.

Manoharan Dhanalakshmi, Subramaniam Ananda Thangadurai, Swaminathan Gomathi. In vivo antitumor activity of ethanolic extract of lepidagathis pungens nees whole plant. IJRPS 2020;11(4):6763-70. doi: 10.26452/ijrps.v11i4.3614.

Devkar RA, Chaudhary S, Adepu S, Xavier Seena K, Chandrashekar KS, Setty MM. Evaluation of antiurolithiatic and antioxidant potential of lepidagathis prostrata: a pashanbhed plant. Pharm Biol. 2016;54(7):1237-45. doi: 10.3109/13880209.2015.1066397, PMID 26171886.

https://www.flowersofindia.

Joshi RK. Chemical composition of the essential oil of Lepidagathis fasciculata from Bondla Forest of Goa, India. Nat Pd Commu. AugNat Prod Commun. 2013;8(8):1163-4. doi: 10.1177/1934578X1300800834, PMID 24079194.

Mahendra CP. Taxonomy and ethnobotany of plant Lepidagathis of family acanthaceae of dausa Rajasthan. Int J Appl Res Jan. 2019;5(1);8.i4d.1181:553-7. doi: 10.22271/plants.2020.

Pancholi B. Phenolics and antioxidant potentials of some medicinally important arid zone plants. Int J Herb Feb. 2022;10(2):05-10.

Vasudevan K, Sanil Kumar R, Sabu MC. Evaluation of hepatoprotective activity of Dracaena ternifloraroxb. Against ethanol induced hepatic injury in wistar albino rats. Asian J Pharm Clin Res. 2023 Oct;16(1):86-90. doi: 10.22159/ajpcr.2023v16i1.46287.

Karna S, RK, ND. Anticancer activity of silver nanoparticle of prodigiosin on lung cancer. Int J App Pharm 2023;15:264-8. doi: 10.22159/ijap.2023v15i1.43628.

Gupta M. Synergistic anticancer effects of natural products and their mode of action. Asian J Pharm Clin Res. 2021 Jan;14(2):15-21. doi: 10.2215/ajpcr.2021v14i2.40552.

http://www.flowersofindia.net. [Last accessed on 03 Apr 2023]

https://sites.google.com/site/efloraofindia. [Last accessed on 03 Apr 2023].

Published

01-05-2023

How to Cite

PONNUSAMY, S., and S. BALAKRISHNAN. “GENUS LEPIDAGATHIS (ACANTHACEAE): REVIEW OF ITS ETHANOBOTANY, PHYTOCHEMISTRY AND PHARMACOLOGICAL POTENTIAL”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 15, no. 5, May 2023, pp. 1-7, doi:10.22159/ijpps.2023v15i5.47280.

Issue

Section

Review Article(s)