ACETAMINOPHEN-INDUCED TOXIC EPIDERMAL NECROLYSIS IN PEDIATRIC PATIENTS-A CASE SERIES

DHARMESH MEVADA; PRATIK CHABHADIYA; ANIL SINGH

doi:10.22159/ijpps.2024v16i7.48175

Authors

DHARMESH MEVADA Department of Pharmacology, PDU Govt Medical College, Rajkot, India
PRATIK CHABHADIYA Department of Pharmacology, PDU Govt Medical College, Rajkot, India https://orcid.org/0000-0002-1374-2711
ANIL SINGH Department of Pharmacology, PDU Govt Medical College, Rajkot, India

DOI:

https://doi.org/10.22159/ijpps.2024v16i7.48175

Keywords:

Toxic epidermal necrolysis, Adverse drug reactions, Paracetamol, Acetaminophen

Abstract

Acetaminophen is the most widely used over-the-counter medication for treating fever and pain. While adverse reactions to this drug are infrequent, they can occasionally result in severe and potentially fatal events, such as Toxic Epidermal Necrolysis (TEN). Due to the rarity of such reactions, there is a limited amount of information available about toxic epidermal necrolysis caused by acetaminophen. This case series will contribute to the existing knowledge in this area. In our cases, acetaminophen is the most suspected drug for the development of toxic epidermal necrolysis in patients. Causality assessment in all of these adverse drug reaction in context with World Health Organization (WHO) causality assessment scale suggests “Possible.” This case series concludes that severe hypersensitivity reactions like TEN caused by acetaminophen use and which can be potentially life-threatening which needs additional treatment.

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