EVALUATION OF ANTI ULCER ACTIVITY OF HYDROALCOHOLIC EXTRACTS OF GYMNEMA SYLVESTRE ON ALBINO WISTAR RATS
DOI:
https://doi.org/10.22159/ijpps.2023v15i10.48922Keywords:
Gymnema sylvestre, Anti-ulcer, Hydroalcoholic extract, Traditional medicine, Pylorus ligation ulcer, NSAIDs induced ulcerAbstract
Objective: The present research is designed to evaluate the anti-ulcer activity of HAGS (Hydroalcoholic extract of Gymnema sylvestre) in NSAIDs and pylorus ligation-induced rat models.
Methods: The antiulcer activity of the hydroalcoholic extracts of Gymnema sylvestre (100 and 200 mg/kg, p. o.) was evaluated in ethanol, indomethacin, pylorus ligation and acetic acid-induced ulcer models in rats. Parameters such as mean ulcer indices and percentage ulcer inhibition were assessed in ethanol, indomethacin and acetic acid-induced ulcer models, while the gastric volume, pH, and titratable acidity were evaluated in the pylorus ligation ulcer model.
Results: Hydroalcoholic extract of Gymnema sylvestre (100 mg/kg) and (200 mg/kg) could significantly (P<0.001) reduce the ulcer index, ulcerated area and total acidity compared to standard drug and thereby significantly (P<0.001) increase percentage inhibition of ulcers and protected area which was evident by the significant rise in pH of gastric content. A significant increase was observed in pH, NP-SH, GSH, enzymic antioxidants and protein with a significant decrease in volume of gastric juice, free and total acidity, acid output and LPO levels activities in 100 mg/kg and 200 mg/kg of HAGS treated rats compared to disease control rats. The effect of extracts was dose-dependent and results were comparable to that of the standard drug Cimetidine.
Conclusion: It is concluded that the Hydroalcoholic extract of Gymnema sylvestre shows a significant effect on NSAIDs and Pylorus ligation-induced rat models. It shows a significant reduction in the lesion index.
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Copyright (c) 2023 DHIVYADHARSHINI NAGARAJAN, MANIMEKALAI PICHAIVEL, SABARINATH CHANDRASEKAR, SELVA PRASANTHI PARAMESHWARAN, SARANYA KANNAN
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