PREVALENCE OF DEPRESSION AND ANXIETY IN POLYCYSTIC OVARIAN SYNDROME WOMEN

Authors

  • R. MANOHAR Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India https://orcid.org/0000-0002-9656-9538
  • P. LAKSHMI PRASUNA Department of Psychiatry, Rajiv Gandhi Institute of Medical and Sciences Government General Hospital, Kadapa, Andhra Pradesh, India
  • K. AMAL BAJIMA Department of Pharmacy Practice, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India
  • M. HARITHA REDDY Department of Pharmacy Practice, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India
  • S. NANDI VARDHAN REDDY Department of Pharmacy Practice, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India https://orcid.org/0009-0006-3142-5820
  • T. SAMUEL BABU Department of Pharmacy Practice, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India https://orcid.org/0009-0007-4161-9634

DOI:

https://doi.org/10.22159/ijpps.2024v16i5.50425

Keywords:

Polycystic ovarian syndrome, Polycystic ovarian disorder, Depression, Anxiety, HAM-A, HAM D, Endocrine disorder

Abstract

Objective: The objective of the study was to determine the prevalence of depression and anxiety ranges in women having Polycystic Ovarian Syndrome (PCOS).

Methods: An epidemiological observational study on 80 PCOS patients confirmed through ultrasound scanning over a study period of 6 mo at Government General Hospital, RIMS, KADAPA. HAM-D and HAM-A assessment scales were used to analyze the severity of depression and anxiety in PCOS women.

Results: Among 80 patients, the prevalence of depression is 86.25% (n=69) and anxiety is 93.75% (n=75). Among 69 depressed patients 38 mild, 28 moderate, and 3 severe ranges were noted. Among 75 patients with anxiety, 52 mild, 18 moderate, and 5 severe ranges were noted. The age of the patient does not show a major difference in the development of depression and anxiety. PCOS women who married and have children (n=45) were mostly affected with depression (n=39) and anxiety (n=43). Menstrual irregularity in PCOS patients with depression and anxiety is majorly seen among those who have last menstrual between 30–60 d. Middle-income patients were affected by depression and anxiety greatly, according to this study.

Conclusion: We conclude that the prevalence rate of depression and anxiety is greater in PCOS patients.

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References

Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E. American association of clinical endocrinologists, american college of endocrinology, and androgen excess and pcos society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome–part 1. Endocr Pract. 2015;21(11):1291-300. doi: 10.4158/EP15748.DSC, PMID 26509855.

Ding T, Hardiman PJ, Petersen I, Wang FF, Qu F, Baio G. The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis. Oncotarget. 2017 Jul 12;8(56):96351-8. doi: 10.18632/oncotarget.19180, PMID 29221211, PMCID PMC5707105.

M, JM, UV, VM, DM. “Genetic variations in polycystic ovarian syndrome disease”. innovareacademics.in/index.php/ajpcr/article/view/7498. Asian J Pharm Clin Res. 2015;8:264-8.

Rodriguez Paris D, Remlinger Molenda A, Kurzawa R, Głowinska A, Spaczynski R, Rybakowski F. Psychiatric disorders in women with polycystic ovary syndrome. Psychiatr Pol. 2019 Aug 31;53(4):955-66. English. doi: 10.12740/PP/OnlineFirst/93105, PMID 31760419.

Zehravi M, Maqbool M, Ara I. Depression and anxiety in women with polycystic ovarian syndrome: a literature survey. Int J Adolesc Med Health. 2021 Aug 23;33(6):367-73. doi: 10.1515/ijamh-2021-0092, PMID 34420269.

Asik M, Altinbas K, Eroglu M, Karaahmet E, Erbag G, Ertekin H. Evaluation of affective temperament and anxiety-depression levels of patients with polycystic ovary syndrome. J Affect Disord. 2015 Oct 1;185:214-8. doi: 10.1016/j.jad.2015.06.043, PMID 26241866.

Liu T, Deng K, Xue Y, Yang R, Yang R, Gong Z. Carnitine and depression. Front Nutr. 2022 Mar 14;9:853058. doi: 10.3389/fnut.2022.853058, PMID 35369081, PMCID PMC8964433.

Tyrer P, Baldwin D. Generalised anxiety disorder. Lancet. 2006 Dec 16;368(9553):2156-66. doi: 10.1016/S0140-6736(06)69865-6, PMID 17174708.

Narmandakh A, Roest AM, de Jonge P, Oldehinkel AJ. Psychosocial and biological risk factors of anxiety disorders in adolescents: a TRAILS report. Eur Child Adolesc Psychiatry. 2021 Dec;30(12):1969-82. doi: 10.1007/s00787-020-01669-3, PMID 33113027, PMCID PMC8563629.

Qureshi SS, Gupta JK, Shah K, Upmanyu N. Prevalence and risk factor of polycystic ovarian syndrome. Asian J Pharm Clin Res. 2016;9:23-5.

Emeksiz HC, Bideci A, Nalbantoglu B, Nalbantoglu A, Celik C, Yulaf Y. Anxiety and depression states of adolescents with polycystic ovary syndrome. Turk J Med Sci. 2018 Jun 14;48(3):531-6. doi: 10.3906/sag-1708-131, PMID 29914248.

Lai W, Cai S. Comment on ”prevalence of anxiety and depression in patients with inflammatory bowel disease”. Can J Gastroenterol Hepatol. 2018 Dec 16;2018:6747630. doi: 10.1155/2018/6747630, PMID 30643760, PMCID PMC6311232.

Hasan M, Sultana S, Sohan M, Parvin S, Rahman MA, Hossain MJ. Prevalence and associated risk factors for mental health problems among patients with polycystic ovary syndrome in Bangladesh: a nationwide cross-sectional study. PLOS ONE. 2022 Jun 22;17(6):e0270102. doi: 10.1371/journal.pone.0270102, PMID 35731829, PMCID PMC9216580.

Vishnubhotla DS, Tenali SN, Fernandez M, Madireddi S. Evaluation of prevalence of PCOS and associated depression, nutrition, and family history: a questionnaire-based assessment. Indian J Endocrinol Metab. 2022 Jul-Aug;26(4):341-7. doi: 10.4103/ijem.ijem_467_21, PMID 36185953, PMCID PMC9519834.

Lin H, Liu M, Zhong D, Ng EHY, Liu J, Li J. The prevalence and factors associated with anxiety-like and depression-like behaviors in women with polycystic ovary syndrome. Front Psychiatry. 2021 Oct 20;12:709674. doi: 10.3389/fpsyt.2021.709674, PMID 34744814, PMCID PMC8563587.

Chaudhari AP, Mazumdar K, Mehta PD. Anxiety, depression, and quality of life in women with polycystic ovarian syndrome. Indian J Psychol Med. 2018 May-Jun;40(3):239-46. doi: 10.4103/IJPSYM.IJPSYM_561_17, PMID 29875531, PMCID PMC5968645.

Sayyah Melli M, Alizadeh M, Pourafkary N, Ouladsahebmadarek E, Jafari-Shobeiri M, Abbassi J. Psychosocial factors associated with polycystic ovary syndrome: a case-control study. J Caring Sci. 2015 Sep 1;4(3):225-31. doi: 10.15171/jcs.2015.023, PMID 26464839, PMCID PMC4591610.

Published

01-05-2024

How to Cite

MANOHAR, R., P. L. PRASUNA, K. A. BAJIMA, M. H. REDDY, S. N. VARDHAN REDDY, and T. S. BABU. “PREVALENCE OF DEPRESSION AND ANXIETY IN POLYCYSTIC OVARIAN SYNDROME WOMEN”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 16, no. 5, May 2024, pp. 67-71, doi:10.22159/ijpps.2024v16i5.50425.

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