PROTECTIVE ROLE OF N-PROPYL GALLATE ON DOCETAXEL-INDUCED CHANGES IN CHOLESTEROL PROFILE
Keywords:
Docetaxel, n-propyl gallate, Total cholesterol, HDL-cholesterolAbstract
Objectives: The aim of the study is to evaluate the protective effects of n-propyl gallate on docetaxel-induced changes in cholesterol profile in vitro.
Methods: Goat blood was used as the lipid source for the model. In the cholesterol profile total cholesterol (TC) and high density lipoprotein (HDL) cholesterol content of goat blood was determined. Interpretation of the results is supported by analysis of variance and also by statistical multiple comparison analysis using least significant different procedure.
Results: The study reveals that docetaxel increased the total cholesterol content and decrease the high density lipoprotein (HDL)-cholesterol content at different time of incubation. The results also showed the protective role on these changes in cholesterol content.
Conclusion: The study showed the antiperoxidative effects of n-propyl gallate and demonstrates its potential to reduce docetaxel-induced changes in the cholesterol profile.
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