• Omprakash G. Bhusnure Channabasweshwar Pharmacy College, Latur Kawa Road, Mahatambasweshwar Chowk, latur
  • Yaswant B. Vibhute Yeshwant Mahavidyalaya
  • Padmaja S Giram Channabasweshwar Pharmacy College (Degree), Latur (MS), India
  • Archana Y. Vibhute Yeshwant Mahavidyalaya
  • Sachin B. Gholve Yeshwant Mahavidyalaya


Schiff bases, Nil, Solvent-free, Microwave heating, Environmentally friendly


Objective: To optimize microwave assisted solvent free synthesis of Schiff bases of aromatic aldehydes and aromatic amines (ethyl 4-aminobenzoate) by using wetting reagent ð›½-ethoxyethanol. The goal of this study was to investigate the % yields and time required for the completion of reaction for Schiff bases by microwave and conventional conditions.

Methods: Schiff bases have been synthesized by condensation of substituted various aromatic aldehyde (.001 mol) with Ethyl 4-aminobenzoate (.001 mol) by two different methods as by conventional method (Heating) & Microwave accelerated synthesis by using wetting reagent ð›½-ethoxyethanol. The reaction time for conventional method and microwave method is in the range of 60-240 min and 10-180s respectively. All the synthesized compounds recrystallized & characterized by IR, NMR, and Mass and element analysis.

Results: The simple microwave assisted solvent-free method for the synthesis of Schiff bases using a wetting reagent (ð›½-ethoxyethanol) led to improvement in the yield of all the target compounds with reduction in their reaction byproducts & substantially reduced the overall process time as expected as compare to traditional method. Excellent isolated yields (up to 96%) were attained within short reaction times (typically, 60s) when the reaction was performed under microwaves irradiation.

Conclusion: The advantages of this environmentally benign and safe protocol include a simple reaction set-up, high product yields, short reaction times as well as the elimination of side products.



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Author Biography

Omprakash G. Bhusnure, Channabasweshwar Pharmacy College, Latur Kawa Road, Mahatambasweshwar Chowk, latur

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How to Cite

Bhusnure, O. G., Y. B. Vibhute, P. S. Giram, A. Y. Vibhute, and S. B. Gholve. “OPTIMIZATION OF MICROWAVE ASSISTED SOLVENT-FREE SYNTHESIS OF SOME SCHIFF BASES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 6, June 2015, pp. 124-8, https://journals.innovareacademics.in/index.php/ijpps/article/view/5552.



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