GAMMA RADIATION AS A METHOD FOR STERILIZATION OF ALL-IN-ONE ADMIXTURES BAGS FOR CLINICAL USE: A STUDY OF STABILITY

Authors

  • Cristiana Barbosa Silva Federal University of Ceará, Brazil
  • Thiago Dias De Vasconcelos Araujo Federal University of Ceará, BrazilFaculty of Pharmacy, Dentistry and Nursing, Research Laboratory in Clinical Pharmacy and Translational
  • Paulo Roberto Leitao Vasconcelos Federal University of Ceará, BrazilFaculty of Medicine, Experimental Surgery Laboratory
  • Haroldo Cesar Beserra De Paula Federal University of Ceará, Brazil Faculty of Chemistry, Physicochemical Laboratory
  • NADIA ACCIOLY PINTO NOGUEIRA Federal University of Ceará, BrazilFaculty of Pharmacy, Dentistry and Nursing, Applied Microbiology Research Laboratory
  • Carlos Alberto Brayner De Oliveira Lira Federal University of Pernambuco, Department of Nuclear Energy
  • Gisele Medeiros Bastos Faculty of Pharmacy, Dentistry and Nursing, Applied Microbiology Research Laboratory
  • David John Woods School of Pharmacy, University of Otago and Best Practice Advocacy Centre, Dunedin, New Zealand
  • MARTA MARIA DE FRANCA FONTELES Federal University of Ceará, BrazilFaculty of Pharmacy, Dentistry and Nursing, Research Laboratory in Clinical Pharmacy and Translational

Keywords:

Total parenteral nutrition, Gamma irradiation, Physicochemical stability, Lipid peroxidation, Microbiological analyses

Abstract

Objective: The aim of this work was to evaluate the stability of all-in-one (AIO) admixtures exposed to gamma irradiation sterilization.

Methods: The samples were divided into four groups with 10 bags each: a) Group I: control samples (bags without sterilization or inoculation with microorganisms); b) Group II: bags sterilized by gamma irradiation; c) Group III: bags inoculated and then irradiated and, d) Group IV: bags only inoculated. The following studies were performed: macroscopic analysis of admixtures; physicochemical stability; degree of lipoperoxidation (LPO), and microbiological tests.

Results: Gamma irradiation sterilization was 100% effective, since no irradiated sample showed growth of microorganisms. All groups exhibited similar particle size distribution, but a longer storage time led to a smaller percentage of large particles. In general, irradiated samples showed reduced LPO.

Conclusion: Gamma irradiation sterilization of these admixtures can be extended to clinical practice, as it results in physicochemically stable admixtures.

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Published

01-06-2015

How to Cite

Silva, C. B., T. D. D. V. Araujo, P. R. L. Vasconcelos, H. C. B. De Paula, N. A. P. NOGUEIRA, C. A. B. De Oliveira Lira, G. M. Bastos, D. J. Woods, and M. M. D. F. FONTELES. “GAMMA RADIATION AS A METHOD FOR STERILIZATION OF ALL-IN-ONE ADMIXTURES BAGS FOR CLINICAL USE: A STUDY OF STABILITY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 6, June 2015, pp. 129-35, https://journals.innovareacademics.in/index.php/ijpps/article/view/5783.

Issue

Vol 7, Issue 6, 2015

Section

Original Article(s)