CANDIDATE MEDICINAL PLANT SPECIES OF DJIBOUTIAN PHARMACOPEIA FOR TESTING PHARMACOLOGICAL ACTIVITIES ON COMMON MICROBIAL DISEASES
DOI:
https://doi.org/10.22159/ijpps.2016v8i10.5788Keywords:
Traditional medicinal plants, Djibouti, Randa, Statistical analysisAbstract
Objective: The aim of the study was to conduct an ethnobotanical study focused on the medicinal plants used in Randa (Djibouti) for testing pharmacological activities on common microbial diseases.
Methods: Plant Ratio (PR), Index of Performance (IP) and the high Informant Consensus Factors (ICF) were calculated to select candidate medicinal species with a pharmacological potential.
Results: From this previous work, it was found that the high Informant Consensus Factors, ICF (0.82) for the category of microbial diseases turned out to merit further perusal. The findings particularly gave an imminent insight that stimulated additional investigations and analyses. Different factors, including Plant Ratio (PR) and Index of Performance (IP) were employed for comparison leading to the selection of 18 candidates species, for subsequent pharmacological screening, and testing for antimicrobial activities. Comparison of the information with that accessed from the literature implicitly hinted that the Djiboutian traditional medical system shares much in common with other traditional medical systems. At least six out of the 18 species have not been pharmacologically tested before.
Conclusion: The comparison of differents factors (IP2, PR and FL') of plants screening have showed that 18 plants species of Randa region, have good healing potential for infectious diseases. This may inspire continued research to build a comprehensive ethnobotanical and ethnopharmacological profiles of the species anticipated to be of the most promising potential for Djibouti and beyond.
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Hassan Abdallah A, Merito A, Hassan S, Aboubaker D, Djama M, Asfaw Z, et al. Medicinal plants and their uses by the people in the region of randa, djibouti. J Ethnopharmacol 2013;148:701–13.
WHO, Djibouti Tuberculosis profile; 2010. Available from: http://www.who.int/tb/data. [Last accessed on 10 Feb 2015].
WHO, Stop Tuberculosis Programme; 2009. Available from: http://www.emro.who.int/djibouti. [Last accessed on 10 Feb 2015].
WHO; 2009. Available from: www.who.int/malaria/ publications/ country-profiles/profile_dji_pdf. [Last accessed on 10 Feb 2015].
Martin GJ. Ethnobotany: a ‘people and plants’ conservation manual. Chapman and Hall, London; 268. p. 1995.
Cotton CM. Ethnobotany: Principles and Applications. John Wiley, Sons, New York; 1996. p. 424.
Heinrich M. Ethnobotany and its role in drug development. Phytother Res 2000;14:479–88.
Heinrich M, Ankli A, Frei B, Weimann C, Sticher O. Medicinal plants in Mexico: healers consensus and cultural importance. Soc Sci Med 1998;47:1863–75.
Betti JL. An ethnobotanical study of medicinal plants among the baka pygmies in the dja biosphere reserve, Cameroon African. Afr Study Monographs 2004;25:1-27.
Alexiades MN. Selected guidelines for ethnobotanical research: a field manual. Advances in economic botany. Vol. 10. The New York Botanical Garden, Bronx; 1996.
Friedman J, Yaniv Z, Dafni A, Palewitch D. A preliminary classification of the healing potential of medicinal plants, based on the rational analysis of an ethnopharmacological field survey among bedouins in negev desert, Israel. J Ethnopharmacol 1986;16:275–87.
Robleh YD. Rapporteur national: rapport national sur L’etat des ressources phytogenetiques. Pour L’Alimentation Et L’Agriculture; 2007. p. 1-63.
Audru J, Cesar J, Cesar J, Lebrun JP. Flore illustree: les plantes vasculaires de la republique de djibouti, mission française et de cooperation culturelle de djibouti. Cirad–EMVT 1994;1:1-300.
Lefloc’h E, Lemordant D, Lignon A, Rezkallah N. Pratiques ethnobotaniques des populations afars de la moyenne vallée d’Awash (Ethiopie). J Ethnopharmacol 1985;14:283–314.
Al-Fatimi M, Wurster M, Schroder G, Lindequist. Antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from Yemen. J Ethnopharmacol 2007;111:657–66.
Maregesi SM, Pieters L, Ngassapa OD, Apers S, Vingerhoets R, Cos P, et al. Screening of some tanzanian medicinal plants from Bunda district for antibacterial, antifungal and antiviral activities. J Ethnopharmacol 2008;119:58–66.
Saini ML, Saini R, Roy S, Kumar A. Comparative pharmacognostical and antimicrobial studies of acacia species (Mimosaceae). J Med Plants Res 2008;2:378-86.
Kubmarawa D, Ajoku GA, Enwerem NM, Okorie DA. Preliminary phytochemical and antimicrobial screening of 50 medicinal plants from Nigeria. Afr J Biotechnol 2007;6:1690-6.
Kigondua EVM, Rukunga GM, Kerikoc JM, Tonui WK, Gathirwab JW, Kirirab PG, et al. Antiparasitic activity and cytotoxicity of selected medicinal plants from Kenya. J Ethnopharmacol 2009;123:504–9.
Samuelsson G, Farah MH, Claeson P, Hagos M, Thulin M, Hedberg O, et al. Inventory of plants used in traditional medicine in somalia. Plants of the families lauraceae-papilionaceae. J Ethnopharmacol 1992;37:93-112.
Pillay P, Maharaj VJ. Investigating South African plants as a source of new antimalarial drugs. J Ethnopharmacol 2008;119:438–54.
Koch A, Tamez P, Pezzuto J, Soejarto D. Evaluation of plants used for antimalarial treatment by the Maasai of Kenya. J Ethnopharmacol 2005;101:95–9.
Eldeen IMS, Van Staden J. Cyclooxygenase inhibition and antimycobacterial effects of extracts from sudanese medicinal plants. S Afr J Bot 2008;74:225–9.
Eldeen IMS, Van Staden J. In vitro pharmacological investigation of extracts from some trees used in sudanese traditional medicine. S Afr J Bot 2007;73:435–40.
McGawa LJ, Lall N, Meyerb JJM, Eloff JN. The potential of South African plants against mycobacterium infection. J Ethnopharmacol 2008;119:482–500.
Ngutaa M, Mbariaa JM, Gakuyab DW, Gathumbi PK, Kiamad SG. Traditional antimalarial phytotherapy remedies used by the South Coast community, Kenya. J Ethnopharmacol 2010; 131:256–67.
Salem AZM, Robinson PH, El-Adawy MM, Hassan AA. In vitro fermentation and microbial protein synthesis of some browse, tree leaves with or without the addition of polyethylene glycol. Anim Feed Sci Technol 2007;138:318–30.
Geissler PW, Harris ST, Prince RJ, Olsen A, Odhiambo RA, Oketch-Rabah H, et al. Medicinal plants used by Luo mothers and children in Bondo district, Kenya. J Ethnopharmacol 2002;83:39-54.
Mbwambo ZH, Moshi MJ, Masimba PJ, Kapingu MC, SO Nondo R. Antimicrobial activity and brine shrimp toxicity of extracts of Terminalia brownii roots and stem. BMC Comple-mentary Altern Med 2007;7:9.
Kareru PG, Gachanja AN, Keriko JM, Kenji GM. Antimicrobial activity of some medicinal plants used by herbalists in Eastern Province, Kenya. Afr J Tradit Complementary Altern Med 2008;5:51–5.
Kareru PG, Kenji GM, Gachanja AN, Keriko JM, Mungai G. Traditional medicines among the Embu and Mbeere peoples of Kenya. Afr J Tradit Complementary Altern Med 2007;4:75–86.
Abutbul S, Golan-Goldhirsh A, Barazani O, Ofir R, Zilberg D. Screening of desert plants for use against bacterial pathogens in fish. Israeli J Aquaculture Bamidgeh 2005;57:71-80.
Abdel Sattar E, Harraz FM, El Gayed SH. Antimicrobial activity of extracts of some plants collected from the kingdom of Saudi Arabia. Med Sci 2008;15:25-33.
Barakat HH, El-Mousallamy AMD, Souleman AMA, Awadalla S. Flavonoids of Ochradenus baccatus. Phytochemistry 1991;30:3777-9.
El-Ghazali GE, Al-Khalifa KS, Saleem GA, Abdallah EM. Traditional medicinal plants are indigenous to Al-Rass province, Saudi Arabia. J Med Plants Res 2010;4:2680-3.
Kiswii TM. Aspergillus flavus and aflatoxin levels in stored maize in Eastern kenya and antifungal activity of some plant extracts department: plant and Microbial Sciences. Thesis. Available from: http://hdl.handle.net/123456789/393;2011. [Last accessed on 10 Mar 2015].
Ismail MYM, Assem NM, Zakriya M. Botanicals promoting oral and dental hygiene: a review. Res J Pharm Biol Chem Sci 2010;1:202-6.
Loewenthal R, Pe’er J. Traditional methods used in the treatment of ophthalmic diseases among the turkana tribe in North West Kenya. J Ethnopharmacol 1991;33:227-9.
Teklehaymanot T, Giday M. Quantitative ethnobotany of medicinal plants used by Kara and Kwego semi-pastoralist people in lower omo river valley, debub omo zone, southern nations, nationalities and peoples Regional State, Ethiopia. J Ethnopharmacol 2010;130:76–84.
Lei Zhao, Jun-Yan Tao, Shu-Ling Zhang, Ran Pang, Feng Jin, Ji-Hua Dong, et al. Inner anti-inflammatory mechanisms of petroleum ether extract from Melilotus suaveolens Ledeb. Inflammation 2007;30:213-23.
Moskalenko SA. Slavic ethnomedicine in the soviet far east part I: herbal remedies among Russians/Ukrainians in the sukhodol valley, primorye. J Ethnopharmacol 1987;21:231-51.
Dung NXD, Loi DT. Selection of traditional medicines for study. J Ethnopharmacol 1991;32:57-70.
Khairul Ikram EH, Khoo Hock Eng K, Ismail AMMJA, Idris S, Azlan A, et al. Antioxidant capacity and total phenolic content of Malaysian underutilized fruits. J Food Compos Anal 2009;22:388–93.
Inngjerdingen K, Nergård CS, Diallo D, Mounkoro PP, Berit Smestad Paulsen BS. An ethnopharmacological survey of plants used for wound healing in dogonland, Mali, West Africa. J Ethnopharmacol 2004;92:233–44.
Adamu HM, Abayeh OJ, Agho MO, Abdullahi AL, Uba A, Dukku HU, et al. An ethnobotanical survey of bauchi state herbal plants and their antimicrobial activity. J Ethnopharmacol 2005;99:1–4.
Deeni YY, Sadiq NM. Antimicrobial properties and phytochemical constituents of the leaves of African mistletoe (Tapinanthus dodoneifolius (DC) Danser) (Loranthaceae): an ethnomedicinal plant of Hausaland, Northern Nigeria. J Ethnopharmacol 2002;83:235-40.
Jain A, Katewa SS, Galav PK, Sharma P. Medicinal plant diversity of Sitamata wildlife Sanctuary, Rajasthan, India. J Ethnopharmacol 2005;102:143–57.
Tetalia P, Waghchaurea C, Daswanib PG, Antiab NH, Birdib TJ. Ethnobotanical survey of antidiarrhoeal plants of parinche valley, Pune district, Maharashtra, India. J Ethnopharmacol 2009;123:229–36.
Ghimire K, Bastakoti RR. Ethnomedicinal knowledge and healthcare practices among the Tharus of Nawalparasi district in central Nepal. For Ecol Manage 2009;257:2066–72.
Diehl MS, Atindehoub KK, Téré H, Betschart B. Prospect for anthelminthic plants in the Ivory Coast using ethnobotanical criteria. J Ethnopharmacol 2004;95:277–84.
Behera SK, Misra MK. Indigenous phytotherapy for genito-urinary diseases used by the Kandha tribe of Orissa, India. J Ethnopharmacol 2005;102:319–25.
Mohagheghzadeh A, Faridi P, Shams-Ardakani M, Ghasemi YM. Medicinal smokes. J Ethnopharmacol 2006;108:161–84.
Hedberg I, Hedberg O, Madatic PJ, Mshigeni KE, Mshiif EN, Samuelsson G. Inventory of plants used in traditional medicine in Tanzania. II. Plants of the families dilleniaceae-opiliaceae. J Ethnopharmacol 1983;9:105-28.
Watt JM, Brandwijk BMG. Medicinal and poisonous plants of Southern and Eastern Africa. 2nd ed. E. and S. Livingstone Ltd., Edinburgh, London; 1962.
Ashokan K, Muthuraman MS. Anticancer studies on Orthosiphon pallidus royle and Peristrophe bicalyculata nees. J Pharm Res 2011;4:2654-6.
Hamza OJM, Carolien JP, van den Bout-van den Beukel, Mecky IN Matee, Moshi MJ, Frans HM, et al. Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections. J Ethnopharmacol 2006;108:124–32.
Alasbahi RH, Saï¬yeva S, Craker LE. Antimicrobial activity of some yemen medicinal plants. J Herbs Spices Med Plants 1999;6:75–83.
Khan MR, Ndaalio G, Nkunya MHH, Wevers H, Sawhney AN. Studies on African medicinal plants. Part I. preliminary screening of medicinal plants for antibacterial activity. Planta Med 1980;40:91-7.
Nanyingi MO, Mbaria JM, Lanyasunya AL, GWagate C, Koros KB, Kaburia HF, et al. Ethnopharmacological survey of Samburu district, Kenya. J Ethnobiol Ethnomed 2008;4:14.
Rajkumar V, Guha G, Kumar RA. Therapeutic potential of Acalypha fruticosa. Food Chem Toxicol 2010;48:1709–13.
Chhabra SC, Mahunnah RLA, Mshiu EN. Plants used in traditional medicine in Eastern Tanzania. III. Angiosperms (Euphorbiaceae to Menispermaceae). J Ethnopharmacol 1990;28:255-83.
Mohagheghzadeh A, Mohammadreza PF, Ardakani S, Ghasemi Y. Medicinal smokes. J Ethnopharmacol 2006;108:161–84.
Kokwaro 0. Medicinal plants of East Africa, East African Literature Bureau, Kampala, Nairobi, Dar es Salaam; 1976.
Samuelsson G, Farah MH, CIaesona P, Hagosa M, Thulinb M, Hedbersb O, et al. Inventory of plants used in traditional medicine in somalia. I. plants of the families acanthaceae-chenopodiaceae. J Ethnopharmacol 1991;35:25-63.
Raza M, Choudhary MI, Atta-Ur-Rahman. Medicinal plants with anticonvulsant activities. Atta-ur-Rahman (Ed.). Stud Nat Prod Chem 2000;22:507-53.
Zaidi MA, Crow SA. Biologically active traditional medicinal herbs from Balochistan, Pakistan. J Ethnopharmacol 2005;96:331-4.
Zaidi MI, Crow SA. Biologically active medicinal plants of Pakistan. Res J Univ Balochistan 2003;2:24–8.
Seifu T. Ethnobotanical and ethnopharmaceutical studies on medicinal plants of Chifra district, Afar Region, North Eastern Ethiopia, Addis Ababa University School of Graduate Studies; 2004.
Owais M, Sharad KS, Shehbaz A, Saleemuddin M. Antibacterial efï¬cacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murines salmonellosis. Phytomedicine 2005;12:229–35.
Agarwal R, Diwanay S, Patki P, Patwardhan B. Studies on immunomodulatory activity of Withania somnifera (ashwagandha) extracts in experimental immune inflammation. J Ethanopharmocol 1999;67:27–35.
Weiner MA, Weiner J. Ashwagandha (Indian Ginseng) In: Herbs that Heal, Quantum Books, Mill Valley, California; 1994. p. 70–2.
Asthana R, Raina MK. Pharmacology of Withania somnifera. Indian Drugs 1989;26:199–204.
Elsakk M, Grigorescu E, Stanescu, Dorneanu V. New data referring to the chemistry of Whitania somnifera species. Rev Med Chir Soc Med Nat Lasi 1990;94:385–7.
Aldor Y, Walach N, Modai D, Horn Y. Zinc and copper levels in plasma erythrocytes and whole blood in cancer patients. Klin Wochenschr 1982;60:375–7.
Puri HS, Rasayana. Ayurvedic herbs for longevity and rejuvenation CRC Press: New York; 2002. p. 46–50.
Sinha S, Nos´al’ov´a G, Bandyopadhyay SS, Fleˇskov´a D, Ray B. In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera. J Ethnopharmacol 2011;134:510-3.
Mathur R, Gupta SK, Singh N, Mathur S, Kochupillai Velpandian T. Traditional plant knowledge and use by local healers in Sekory district Jimma Zone South Western Ethiopia. J Ethnopharmacol 2006;105:336–41.
Sudhir S, Budhiraja RD, Miglani GP, Arora B, Gupta IC, Gorg KN. Pharmacological studies on leaves of Withania somnifera. Planta Med 1986;1:61-3.
Al-Fatimi M, Wurster M, Schroder G, Lindequist U. Antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from Yemen. J Ethnopharmacol 2007;111:657-66.
Archibald RG. The use of the fruit of the tree Balanites aegyptica in control of schistosomiasis in the Sudan. Trans R Soc Trop Med Hyg 1933;27:207-10.
Plank HK. All parts of the desert date is toxic to snails. Annual Report USDA, AES. Puerto Rico Mayaquez, Puerto Rico; 1945. p. 24.
Liu HW, Nakanishi K. The structures of balanitins. Potent molluscicides isolated from Balanites aegyptiaca. Tetrahedron 1982;38:513-9.
Gaudin O, Vacheriat R. Rotenone and the ichthyotoxic power in some plants of the french Sudan. Bull Sci Pharmacol 1938;45:385-94.
Spencer CF, Koniuszy FR, Rogers EF, Shavel JRJ, Easton NR, Kaczka EA, et al. Survey of plants for antimalarial activity. Lloydia 1947;10:145-74.
Ampofo O. Plants that heal. World Health Mag. WHO; 1977. p. 26-30.
Schreiber FG, Schubert M. Toxicity of some chemical compounds to cercariae of Schistosoma mansoni. J Parasitol 1949;35:364-6.
Dhar ML, Dhar MN, Dhawan BN, Mehrotra BN, Srimal RC, Tandon JS. Screening of Indian plants for biological activity. Part IV. Indian J Exp Biol 1973;1:43-54.
Taniguchi M, Chapya A, Kubo, Nakanishi K. Screening of East African plants for antimicrobial activity. I. Chem Pharm Bull 1978;26:2910-3.
Heal RE, Rogers EF, Wallace RT, Starnes OA. Survey of plants for insecticidal activity. Lloydia 1950;13:89-162.
Sparg SG, Light ME, Van Staden J. Biological activities and distribution of plant saponins. J Ethnopharmacol 2004;94:219–43.
Dragendorff G. Die Heilpflanzen der verschiedenen Vtlker und Zeiten. F. Enke, Stuttgart; 1898.
Creach P. Balanites aegyptiaca and its various uses in Tchad territory. Rev Bot Appl Agric Trop 1943;20:578-93.
Hussein Ayoub SM, Baerheim Svendsen A. Medicinal, and aromatic plants in the Sudan. Usage and exploration. Fitoterapia 1981;52:243-6.
Hammiche V, Maiza K. Traditional medicine in central sahara: Pharmacopoeia of tassili N’ajjer. J Ethnopharmacol 2006; 105:358–67.
Iwu MM. Handbook of African Medicinal Plants. CRC Press: Boca Raton, Florida, USA; 1993.
Patel M. Effect of Dodonaea angustifolia on adherence of Candida albicans. Scientific meeting of the South African division of IADR. Microbiology/immunology/Infection Control, University of Witwatersrand, Wits, 2050, South Africa; 2006.
Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N. Activity against Mycobacterium smegmatis and Mycobacterium tuberculosis by an extract of South African medicinal plants. Phytother Res 2008;22:841-5.
Daman G, Gideon M, Patel M. Antifungal activity of a medicinal plant Dodonaea angustifolia. Scientific meeting of the South African division of IADR. Microbiology/immunology/Infection Control, University of Witwatersrand, Wits, 2050, South Africa; 2006.
Giday M, Teklehaymanot T, Animut A, Mekonnen Y. Medicinal plants of the Shinasha, Agew-awi and Amhara peoples in northwest Ethiopia. J Ethnopharmacol 2007;110:516–52.
Dominguez XA, Franco R, Cano CG, Chavez CN. Medicinal plants of Mexico. Part XLIV. Isolation of 3, 6, 40-trimethoxy-5, 7-dihydroxyflavone from chapuliztle (Dodonaea viscosa var. angustifolia Jacq.). Rev Latino Am Quim 1980;11:150–1.
Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of Southern and Eastern Africa. 2nd ed. E and S. Livingstone, Ltd., London; 1981. p. 931–2.
Mativandlela SPN. Antituberculosis activity of flavonoids from Galenia africana phytochemistry and medicinal uses of selected medicinal plants. The university of Pretoria, chapter 3 thesis; 2009. p. 77-104.
Teklehaymanot T, Giday M, Medhin G, Mekonnen Y. Knowledge and use of medicinal plants by people around Debre Libanos monastery in Ethiopia. J Ethnopharmacol 2007;111:271–83.
Wondimu T, Asfaw Z, Kelbessa E. Ethnobotanical study of medicinal plants around ‘Dheeraa’ town, Arsi Zone, Ethiopia. J Ethnopharmacol 2007;112:152–60.
Ali NAA, Wurster M, Arnold N, Lindequist U, Wessjohann L. Essential oil composition from oleogum resin of Soqotraen Commiphora kua. Rec Nat Prod 2008;2:3:70-5.
Manguro LOA, Ugi I, Lemmen P. Further bisabolenes and dammarane triterpenes of Commiphora kua resin. Chem Pharm Bull 2003;51:479-82.
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