SIMULTANEOUS ESTIMATION OF FAMOTIDINE AND RABEPRAZOLE SODIUM: METHOD DEVELOPMENT AND VALIDATION BY UV-SPECTROPHOTOMETRIC METHOD
Keywords:
Famotidine, Rabeprazole, Nil, simultaneous estimationAbstract
Objectives: Study aimed for the simultaneous estimation of Famotidine and Rabeprazole sodium at 263 nm, λmax of Famotidine and 284 nm, λmax of Rabeprazole sodium.
Methods: Method development and validation were done by UV spectrophotometric method.
Results: The method developed obeyed Beer-Lambert's law in the concentration range of 5-30 g/ml for both famotidine and rabeprazole. The results of the analysis have been successfully validated statistically. The %RSD confirms the precision of the proposed method and Recovery studies show the accuracy of the method.
Conclusion: This method was simple, precise and accurate and was successfully applied to the determination of these drugs in the laboratory mixture.
Â
Downloads
References
Kesur BR, Saluknke VR, Magdum CS. Development and validation of uv spectrophotometric method for simultaneous estimation of ibuprofen and famotidine in bulk and formulated tablet dosage form. Int J Pharm Pharma Sci 2012;4(4):271-4.
Sahu R, Nagar P, Bhattacharya S, Jain D. Simultaneous spectrophotometric estimation of famotidine and domperidone in combined tablet dosage form. Int J Pharma Sci 2006;68(4):503-6.
Deulgaonkar YB, Patel JA, Moreshwar P, Mahajan, Sawant SD. UV spectrophotometric method for simultaneous estimation of rabeprazole sodium and levosulpiride in bulk and tablet dosage form. Pharm Chem 2013;5(3):163-8.
Thakkar DG. Development and validation of UV spectroscopic and RP-HPLC method for simultaneous estimation of levosulpiride and rabeprazole sodium in bulk and tablet dosage form. J Pharm Sci Biol Res 2013;3(3):108-14.
Toruner M, Bektas M, Cetinkaya H, Soykan I, Ozden A. The effect of rabeprazole alone or in combination with H2 receptor blocker on intragastric pH: a pilot study. Turk J Gastroenterol 2004;15(4):225-8.