AN ETHNOBOTANICAL SURVEY OF ANTI-MALARIAL PLANTS IN SOME HIGHLY MALARIA AFFECTED DISTRICTS OF ASSAM
Keywords:
Ethno knowledge, Anti-malarial, Traditional practitioners, Artemisinin Combination Therapy, Oral administration, Therapeutic indexAbstract
Objective: An ethnobotanical survey of potent anti-malarial plants used by different tribes and communities of highly malaria affected seven districts of Assam, India.
Methods: Personal discussions and group interviews were held with the traditional practitioners. Samples were collected and authentically identified. Detailed ethno knowledge on the plant parts used and mode of administration of the plant extracts was documented. Literature survey was carried out on identified plant species and analyzed for their medicinal importance.
Results: A total of 22 plant species belonging to 20 botanical families were collected and identified from different locations of seven districts of Assam. Different plant parts such as leaves, root, flower, bark etc. were found to process through different basic methods (infusion, decoction, direct mechanical crushing and maceration) for extracting the anti-malarial crude phytochemicals by the traditional healers. Extensive literature on the broad spectrum medicinal values other than anti-malarial activity of the plant species suggested a strong scientific background of selecting those particular plants species by the traditional practitioners.
Conclusion: Indigenous plant species with strong claim of the natural source of anti-malarial moieties were identified in the present ethno-botanical survey. All the 22 plant species investigated could be a potential source of new antimalarial therapies.
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References
Guidelines of Diagnosis and Treatment of Malaria in India; 2011. Available from: URL: http://nvbdcp.gov.in/Doc/ Guidelines. [Last accessed on 1 Mar 2015].
Nogueira CR, Lopes LMX. Antiplasmodial natural products. Molecules 2011;16:2146–90.
World Health Organization. World Malaria Report Geneva: World Health Organization; 2014. Available from: URL: http://www.who.int/malaria/publications/world_malaria_report_2014. [Last accessed on 1 Mar 2015].
Sehgal PN, Sharma MID, Sharma SL, Gogal S. Resistance to chloroquine in falciparum malaria in Assam state, India. J Communicable Dis 1975;5:175–80.
Mohapatra PK, Sarma DK, Prakash A, Bora K, Ahmed MA, Sarma B, et al. Molecular evidence of increased resistance to anti-folate drugs in Plasmodium falciparum in north-east india: a signal for potential failure of Artemisinin plus Sulphadoxine-Pyrimethamine combination therapy. PLos One 2014;9:e105562–62.
Prakash A, Sharma SK, Mohapatra PK, Bhattacharjee K, Gogoi K, Gogoi P, et al. In vitro and in vivo antiplasmodial activity of the root extracts of Brucea mollis Wall. ex Kurz. Parasitol Res 2012;112:637–42.
Mishra K, Dash AP, Swain BK, Dey N. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. Malar J 2009;8:26.
Ramazani A, Zakeri S, Sardari S, Khodakarim N, Dinparast N. In vitro and in vivo antimalarial activity of Boerhavia elegans and Solanum surattense. Malar J 2010;9:124.
Botsaris AS. Plants used traditionally to treat malaria in brazil: the archives of flora medicinal. J Ethnobiol Ethnomed 2007;3:18.
Carvalho LH, Brandao MGL, Santos-Filho D, Lopes JLH, Krettli AU. Antimalarial activity of crude extracts from Brazilian plants studied in vivo in Plasmodium berghei infected mice and in vitro against Plasmodium falciparum in culture. Braz J Med Biol Res 1991;24:1113–23.
Ratsimamanga US, Rasoanaivo P, Milijaona R, Rakotoarimanga J, Rafatro H, Robijaona B, et al. In vitro antimalarial activity, chloroquine potentiating effect and cytotoxicity of alkaloids of Hernandia voyronii Jum. (Hernandiaceae). Phytother Res 1994;8:18–21.
Valsaraj R, Pushpangadan P, Nyman U, Smitt UV, Adsersen A, Guditsen L. New antimalarial drugs from Indian medicinal plants. International Seminar on Recent Trends in Pharmaceutical Sciences: Oatacamund Abstract No 2A; 1995. p. 18–20.
Dev V, Hira CR, Rajkhowa MK. Malaria-attributable morbidity in Assam, north-eastern India. Ann Trop Med Parasitol 2001;95:789–96.
Korenromp E. World Malaria Report: Roll Back Malaria. World Health Organization: Geneva; 2004.
Dua VK, Dev V, Phookan S, Gupta NC, Sharma VP, Subbarao SK. Multi-drug resistant Plasmodium falciparum malaria in Assam, India: timing of recurrence and antimalarial drug concentrations in whole blood. Am J Trop Med Hug 2003;69:555–7.
Namsa ND1, Mandal M, Tangjang S. Anti-malarial herbal remedies of northeast India, Assam: an ethnobotanical survey. J Ethnopharmacol 2011;133:565–72.
Rama Shankar, Sourabh Deb, BK Sharma. Antimalarial plants of northeast India: An overview. J Ayurveda Integrative Med 2012;3:10–6.
S Paul, N Devi, GC Sarma. Ethnobotanical utilization of some medicinal plants by bodo peoples of manas biosphere reserve in the treatment of malaria. Int J Pharm Res 2013;4:102–5.
Gogoi B, Zaman K. Phytochemical constituents of some medicinal plant species used in recipe during ‘Bohag Bihu’ in Assam. J Pharmacogn Phytochem 2013;2:30–40.
Mallik J, Akhter R. Phytochemical screening and in-vitro evaluation of reducing power, Cytotoxicity and anti-fungal activities of ethanol extracts of Cucumis sativus. Int J Pharm Biol Arch 2012;3:555–60.
Kabir MH, Hasan N, Rahman MM, Rahman MA, Khan JA, Hoque NT, et al. A survey of medicinal plants used by the Deb barma clan of the Tripura tribe of Moulvibazar district, Bangladesh. J Ethnobiol Ethnomed 2014;10:19.
Govindarajan M, Rajeswary M. Mosquito larvicidal properties of Impatiens balsamina (Balsaminaceae) against Anopheles stephensi, Aedes aegypti and Culex Quinquefasciatus (Diptera: Culicidae). J Coastal Life Med 2014;2:222–4.
Sosan MB, Adewoyin FB, Adewunmi CO. Larvicidal properties of three indigenous plant oils on the mosquito Aedes aegypti. Niger J Nat Prod Med 2001;5:30–3.
Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. High therapeutic potential of Spilanthes acmella: a review. EXCLI J 2013;12:291–312.
Nambiar VPK, Sasidharan N, Renuka C, Balagopalan M. Studies on the Medicinal plants of Kerala forests. Kerala forest research institute PEECHI, THRISSUR December; 1985.
KA Azizor. Biodiversity prospecting of tropical plants for medicinal uses. Third National Congress on Genetics; 1998. p. 18–9.
Kar A, Gogoi UK, Rabfia B, Gogoi HK. In vitro evaluation of antimicrobial properties of stem with leaf extract of curanga amara juss against human pathogenic microorganisms. Asian J Microbiol Biotechnol Environ Sci Paper 2005;7:759–62.
Ghoshal S, Prasad BN, Lakshmi V. Antiamoebic activity of piper longum fruits against Entamoeba histolytica in vitro and in vivo. J Ethnopharmacol 1996;50:167–70.
Sahoo S, Ghosh G, Das D, Nayak S. Phytochemical investigation and in vitro antioxidant activity of an indigenous medicinal plant Alpinia nigra B. L. Burtt. Asian Pac J Trop Biomed 2013:3:871–6.
Gupta S, Walia A, Malan A. Phytochemistry and pharmacology of cedrus deodera: an overview. Int J Pharma Sci Res 2011;2: 2010–20.
Basri F, Sharma HP, Firdaus S, Jain P, Ranjan A. A review of Ethnomedicinal plant-Vitex negundo Linn. Int J Adv Res 2014;2:882–94.
Wang KW, Wu S. Stemona tuberosa compounds in the treatment of pertussis. Chung Hua Erh Ko Tsa Chih 1960;11:143.
Tabassum S, Mahmood S, Hanif J, Hina M, Uzair B. An overview of medicinal importance of swertia chirayita. Int J Appl Sci Technol 2012;2:298–304.
Dash DK, Yeligar VC, Nayak SS, Ghosh T, Rajalingam D, Sengupta P, et al. Evaluation of hepatoprotective and antioxidant activity of Ichnocarpus frutescens (Linn.) R. Br. on paracetamol-induced hepatotoxicity in rats. D. Trop J Pharm Res 2007;6:755–65.
Waliullah TM, Yeasmin AM, Wahedul IM, Parvez H. Evaluation of antimicrobial study in in vitro application of Clerodendrum infortunatum Linn. Asian Pac J Trop Dis 2014;4:484–8.
Srivastava RC, Singh RK, Community Apatani, Mukherjee TK. Indigenous biodiversity of apatani plateau: learning on biocultural knowledge of Apatani tribe of Arunachal Pradesh for sustainable livelihoods. Indian J Traditional Knowledge 2010;9:432–42.
Ukwe VC, Epueke EA, Ekwunife OA, Okoye TC, Akudor GC, Ubaka CM. Antimalarial activity of aqueous extract and fractions of leaves of Ageratum conyzoides in mice infected with Plasmodium berghei. Int J Pharm Sci 2010;2:33–8.
Kham MH, Yadava PS. Antidiabetic plants used in Thoubal district of Manipur, Northeast India. Indian J Traditional Knowledge 2010;9:510–4.
Gandhi D, Mehta P, Dillenia indica Linn. and Dillenia pentagyna Roxb: Pharmacognostic, Phytochemical and Therapeutic aspects. J Appl Pharm Sci 2013;3:134–42.
Singh V, Raghav PK. Review in pharmacological properties of Caesalpinia bonduc (L.). Med Aromat Plants 2012;2:514–30.
Kshirsagar AD, Mohite R, Aggrawal AS, Suralkar UR. Hepatoprotective medicinal plants of Ayurveda–A review. Asian J Pharm Clin Res 2011;4:1–8.