GARDINERIN, A BIOLOGICALLY ACTIVE ACETOGENIN FROM THE SRI LANKAN GONIOTHALAMUS GARDINERI HOOK. F. AND THOMSON

Authors

  • Aruna J. Weerasinghe University of Peradeniya
  • Anura Wickramasinghe Department of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka
  • Gavin Carr University of Peradeniya
  • David Williams University of Peradeniya
  • Raymond Andersen University of Peradeniya
  • Veranja Karunaratne University of Peradeniya

Keywords:

Gardinerin, New acetogenin, Goniothalamus gardineri, Annonaceae, Antioxidant activity, Cytotoxicity, Mosquitolarvicidal activity

Abstract

Objective: The study was undertaken to isolate biologically active compounds from Goniothalamus gardineri, a plant endemic to Sri Lanka.

Methods: Roots and flowers of Goniothalamus gardineri were extracted into dichloromethane and methanol. A new acetogenin, gardinerin isolated by column chromatography of the dichloromethane extract was structurally characterized using NMR and Mass spectroscopies. It was found to be mosquito larvicidal (against 2nd instar larvae of Aedes aegypti), cytotoxic (in the brine shrimp assay) and antioxidant (DPPH assay).

Results: Gardinerin exhibited potent mosquitolarvicidal activity (LC50 = 0.0744±0.37 ppm.), cytotoxicity (LC50 = 1.5±0.37 ppm) and antioxidant activity (IC50 =10.02±0.01 ppm). The same extract furnished (5R)-goniothalamin. The hexane extract of the flowers of G. gardineri yielded poriferesterol and stigmast-4, 22-dien-3-one.

Conclusion: The endemic plant G. gardineri has yielded an acetogenin possessing highly potent antioxidant, cytotoxic and mosquitolarvicidal activity.

 

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Published

01-09-2015

How to Cite

Weerasinghe, A. J., A. Wickramasinghe, G. Carr, D. Williams, R. Andersen, and V. Karunaratne. “GARDINERIN, A BIOLOGICALLY ACTIVE ACETOGENIN FROM THE SRI LANKAN GONIOTHALAMUS GARDINERI HOOK. F. AND THOMSON”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 9, Sept. 2015, pp. 459-61, https://journals.innovareacademics.in/index.php/ijpps/article/view/7174.

Issue

Vol 7, Issue 9, 2015

Section

Original Article(s)