• Alpa Pragnesh Gor Department of Pharmacology, Pramukhswami Medical College, Karamsad 388325
  • Ankush Ajbani Pramukhswami Medical College
  • Krunal Dalal Pramukhswami Medical College


Antibiotics, Fixed Dose Combination, Surgical departments


Objective: To study the prescribing pattern and to assess the rationality of fixed dose combinations of antibiotics in surgical department of a tertiary care teaching hospital.

Methods: A cross-sectional prospective study was carried out in four inpatients departments (Surgery, Orthopaedics, ENT, Obstetrics & Gynaecology) of a 550-bed tertiary care teaching hospital. Total 100 inpatients data from all four surgical departments were evaluated for prescribing pattern of fixed dose combinations of antibiotics. Data were also assessed for demographic information like number of single formulations of antibiotics used & fixed dose combinations other than antibiotics.

Results: Among four departments, FDCs were prescribed as the highest percentage (20.35%) in the surgery department out of all prescriptions. Maximum median duration of stay was nine days in Orthopaedics. Amoxicillin+Clavulanic acid was the most common FDC prescribed out of all antimicrobials in three departments except orthopaedics. O &G department had maximum percentage (45%) of prescription of Clotrimazole+Tinidazole+Clindamycin, whereas this combination was not prescribed by any of other three departments. Cefoperazone+Sulbactam FDCs were maximally prescribed by surgery department (30.43%) followed by orthopaedics. Diclofenac+Paracetamol and Folic acid combinations were the most commonly prescribed FDC's other than antimicrobials among the subjects.

Conclusion: It was observed that the hospital physicians prescribed antibiotics more rationally with no banned drugs and very few new drugs. Rational prescribing of antibiotics would help avoid polypharmacy and prevent drug resistances.



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Sreedhar D, Subramanian G, Udupa N. Combination drugs: are they rational? Curr Sci 2006;91:406. [Last accessed on 2015 Mar 11].

Amitava S. Indian market's fixation with fixed dose combinations (Editorial). Rational Drug Bull 2002;12:1.

Margaret AP, Samuel LS. Chemotherapy of protozoa infections. In: Brunton LL, Lazo JS, Parker KL. editors. Goodman and Gilman's the pharmacological basis of therapeutics. 11. New York: McGraw-Hill; 2006. p. 1049–50.

WHO drug information. Geneva: WHO; 2003. Available at: [Last accessed on 12 Mar 2015].

Sharma K, Sharma A, Singh V, Pilania D, Sharma Y. Irrational fixed dose combinations and need for intervention: understanding of dental clinicians and residents. J Clin Diagn Res 2014;8:ZC49-ZC52.

Gautam C, Saha L. Fixed dose drug combinations (FDCs): rational or irrational: a view point. Br J Clin Pharmacol 2008;65:795–96.

Deshmukh V, Khadke V, Patil A, Lohar P. Study of prescribing pattern of antimicrobial agents in indoor patients of a tertiary care hospital. Int J Basic Clin Pharmacol 2013;2:281-5.

Remesh A, Salim S, Gayathri AM, Nair U, Retnavally KG. Antibiotics prescribing pattern in the in-patient departments of a tertiary care hospital. J Res Pharm Pract 2013;4:71-6.

Jimmy B, Jose B. Patient medication adherence: measures in daily practice. Oman Med J 2011;26:155–9.

Alam K, Poudel A, Palaian S. Fixed dose combination antimicrobials practices in Nepal–review of literature. J Clin Diagn Res 2010;4:3255-60.

Kamarh S, Varun H, Rani U, Aithal S, Patil U. Prescribing patterns of antimicrobials in surgical departments in a tertiary care hospital in south india. Int J Pharma Sci Res 2014;5:1051-8.

Maladkar M, Techchandani C, Dave U. Clindamycin, Clotrimazole and tinidazole in mixed Vaginosis-A Real World†clinical experience. Internet J Gynecol Obstet 2015;3:49-54.

Mundade Y, Somani R, Srivastva A, Kulkarni K. A comparative study for efficacy and tolerability of satranidazole plus ofloxacin versus ornidazole plus ofloxacin in periodontal infections. Indian Med Gazette 2013;448-53.

Patel DM, Soneji JA, Patel PB, Patel CN. Development and validation of a method for simultaneous estimation of ofloxacin and ornidazole in different dissolution media. J Pharmacol Methods 2012;3:102-5.

Raghunath M, Bakal S. Formulation and evaluation of a fixed dose combination of ceftriaxone disodium and ornidazole. Int J Pharm Pharm Sci 2013;5:750-6.

John LJ, Devi P, John J, Guido S. Drug utilization study of antimicrobial agents in medical intensive care unit of a tertiary care hospital. Asian J Pharm Clin Res 2011;4:81-4.

Shankar PR, Partha P, Dubey AK, Mishra P, Deshpande VY. Intensive care unit drug utilization in a teaching hospital in Nepal. Kathmandu Univ Med J 2005;3:130-7.

Curcio DJ. On behalf of the latin american antibiotic use in intensive care unit group. Antibiotic prescription in intensive care units in latin america. Rev Argent Microbiol 2011;43:203-11.

Shankar PR, Upadhyay DK, Subish P, Bhandari RB, Das B. Drug utilisation among older inpatients in a teaching hospital in Western Nepal. Singapore Med J 2010;51:28-34.

Alanis JA. Resistance to antibiotics: are we in the post-antibiotic era? Arch Med Res 2005;36:697-5.

Lampiris HW, Maddix DS. Clinical use of antimicrobial agents. In: Katzung BG (editor) Basic and clinical pharmacology. 8th editon. Boston Burr Ridge, Mc Graw Hill; 2000.



How to Cite

Gor, A. P., A. Ajbani, and K. Dalal. “USE OF FIXED DOSE COMBINATIONS OF ANTIBIOTICS IN A SURGICAL DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 11, Nov. 2015, pp. 259-62,



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