• J. Anu Rita Department of Psychiatry, Sree Balaji Medical College and Hospital
  • S. Nambi Sree Balaji Medical College and Hospital


Recurrent depressive disorder, Hypothyroidism, Mood stabilizer, Biopsychosocial cause


Recurrent depressive disorder is a lifelong illness with relapses and remissions. The aetiology is biopsychosocial, genetic factors contributing and life stressors exaggerating the disease. Due to recurrent episodes the morbidity is quite high both for the patient and the family members. The poor compliance of drugs during the euthymic period acts as a trigger for relapse. The identification of comorbid physical conditions adding fuel to the disease process has to be identified and treated promptly. This case is reported to show the significance of undetected hypothyroidism in a patient with recurrent depressive disorder.



Download data is not yet available.


Coryell W, Endicott J, Keller M. Predictors of relapse into major depressive disorder in a nonclinical population. Am J Psychiatry 1991;148:1353–8.

Dayan CM, Panicker V. Hypothyroidism and depression. Eur Thyroid J 2013;2:168-79.

Chris KW. Schotte. A biopsychosocial model as a guide for psychoeducation and treatment of depression. Depression and Anxiety. 2006;23:312–24.

Kupfer DJ. Long-term treatment of depression. J Clin Psychiatry 1991;52(Suppl 5):28–34.

Keller MB. The long-term treatment of major depression. J Clin Psychiatry 1999;60(Suppl 17):41–5.

Keller MB, Boland RJ. Implications of failing to achieve successful long-term maintenance treatment of recurrent unipolar major depression. Biol Psychiatry 1998;344:348–60.

Robert MA. Hirschfeld. The comorbidity of major depression and anxiety disorders: recognition and management in primary care. Prim Care Companion J Clin Psychiatry 2001;3:244–54.

Cuijpers Pim, Van Straten, Annemieke Andersson, Gerhard van Oppen, Patricia. Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. J Consulting Clin Psychol 2008;76:909-22.

Kae Shimazu, Shinji Shimodera, Yoshio Mino, Atsushi Nishida, Naoto Kamimura, Ken Sawada, Hirokazu Fujita, et al. Furukawa, Shimpei Inoue. Family psychoeducation for major depression: randomised controlled trial. Br J Psychiatry 2011;198:385-90.

H Hayhurst, Z Cooper, ES Paykel, S Vearnals, R Ramana. Expressed emotion and depression. A longitudinal study. Br J Psychiatry 1997;171:439-43.

How land R. General Health, health care utilization, and medical comorbidity in dysthymia. Int J Psychiatry Med 2005;23:211-38.



How to Cite

Rita, J. A., and S. Nambi. “A CASE OF HYPOTHYROIDISM INDUCED RECURRENT DEPRESSIVE DISORDER”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 11, Nov. 2015, pp. 397-8, https://journals.innovareacademics.in/index.php/ijpps/article/view/7926.



Case Study(s)