FTIR ANALYSIS FOR RETINA ASSOCIATED WITH DIABETIC CHANGES AND TREATMENT WITH OAT
Keywords:
Rats, Diabetic, Streptozotocin, Retina, FTIR-OatAbstract
Objective: Diabetes is known to induce oxidative stress along with deranging various metabolisms. One of the most serious complications of diabetes, a disease that has seen a worldwide increase in the prevalence, is diabetic retinopathy, which is a leading cause of acquired blindness. The aim of this study is to evaluate the effect of oat on the diabetic-induced oxidative stress and if this can attenuate the development of diabetic retinopathy.
Methods: Changes on retina structure were performed by using the application of Fourier transform infrared spectroscopy.
Results: The results demonstrated that diabetic retinopathy was associated with changes on the retina structure which appear after received a single dose of streptozotocin (STZ) 60 mg/kg. These changes clearly appeared in the NH-OH, CH and fingerprint regions. The use of oat in case of diabetic was associated with different beneficial effects on the retina constituents, as showed by the changes toward control of the same Fourier transform infrared spectroscopy bands.
Conclusion: Oat can be considered as a novel treatment modality for diabetic retinopathy and further studies is required to optimize dosing and formulations that are maximally effective.
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