• Sebenta Menon Faculty of Pharmacy, Jamia Hamdard
  • Devina Verma Faculty of Pharmacy, Jamia Hamdard
  • Tahir Khuroo Faculty of Pharmacy, Jamia Hamdard
  • Sushama Talegaonkar Faculty of Pharmacy, Jamia Hamdard
  • Zeenat Iqbal Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India


Hypoxoside, Rooperol, Transdermal, Skin Cancer, Antioxidant


Objective: This study was aimed to extract Hypoxoside, a water soluble phytochemical, from the corms of Hypoxis hemerocallidea, and incorporate it into a suitable transdermal carrier system to increase its penetrability and deep dermal delivery for potential antioxidant and anticancer activity.

Methods: The extraction of Hypoxis hemerocallidea corms was carried out by continuous hot extraction method. This extract (20 mg/ml) was loaded into ethosomal vesicular system by cold method and optimized by varying proportions of lecithin and ethanol. The optimized system was then subjected to characterization in terms of particle size, polydispersity index (PDI), entrapment efficiency and invitro permeation and penetration studies.

Results: The optimized vesicle with size of 176.2±11 nm, PDI of 0.231 and entrapment efficiency of 74.2±2.3% was obtained which showed a sustained release pattern of the hypoxoside from the vesicular system. Confocal laser scanning microscopy (CLSM) demonstrated that the vesicles were able to efficiently traverse the skin to a depth of 117.29 µm whereas the mechanism of vesicle-skin interaction was confirmed by histopathological study.

Conclusion: The study indicated that with the development of an efficient delivery system a water soluble phytochemical with antioxidant and anticancer properties can be efficiently delivered to the skin.



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How to Cite

Menon, S., D. Verma, T. Khuroo, S. Talegaonkar, and Z. Iqbal. “EXTRACTION OF A WATER SOLUBLE BIOACTIVE HYPOXOSIDE AND ITS DEVELOPMENT INTO AN ETHOSOMAL SYSTEM FOR DEEP DERMAL DELIVERY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 11, Nov. 2015, pp. 211-5, https://journals.innovareacademics.in/index.php/ijpps/article/view/8240.



Original Article(s)