• Nawal A. Rajab Department of Pharmaceutics, College of Pharmacy, Baghdad University, Baghdad, Iraq
  • Mohammad S. Jawad Baghdad University


Piroxicam, Microsponge, Eudragit RS100, Loading efficiency, Crospovidone


Objective: Piroxicam is a poor water soluble drug; an effort had been made to enhance their dissolution rate through formulating it as a microsponge and then fabricated as a tablet for oral administration.

Methods: Piroxicam microsponges were prepared by quasi-emulsion solvent diffusion method using Eudragit RS100, RL100, S100 with different drug-polymer ratios, three different types of inner phase solvent were used, along with various volumes of the selected organic solvent, the prepared formulas were examined for it its production yield, loading efficiency, particle size and in vitro drug release for formulas have excellent physical properties. Optimum formula that had fast release profile was further fabricated into a tablet using direct compression method, two types of disintegrants along with two different amounts were used, also the addition of microcrystalline cellulose was examined.

Results: The results showed that as the ratio of drug to polymer was increased, the production yield and loading efficiency were enhanced, but the particle size had an inverse relationship. Among the three types of solvent, ethanol was most preferable one; 5 ml of ethanol was most favorable. PF13 (containing Eudragit RS100) have the rapid release profile. No any chemical interaction was observed, microsponge with spherical shape, porous structure was obtained. The prepared tablets have acceptable physical parameters. A dramatic enhancement in the dissolution rate as compared with the pure piroxicam tablet was shown, as well as release profile follows Hixson-Crowell kinetic with non Fickian diffusion.

Conclusion: Microsponge may represent a promising way to increase the dissolution rate of poorly water-soluble drug.



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Das P, Das H, Kumar S, Ghosh A, Begum S. A review on solid dispersions drug delivery systems. Indo Am J Pharm Res 2012;2:1213-21.

Sharma A, Jain P. Techniques to enhance the solubility of poorly soluble drugs: a review. J Global Pharma Technol 2010;2:18-28.

Charde M, Ghanawat P, Welankiwar A, Kumar J, Chakole R. Microsponge a novel new drug delivery system: a review. Int J Adv Pharm 2013;2:62-70.

Patil R, Kemkar V, Patil S. Microsponge drug delivery system: a novel dosage form. Am J PharmTech Res 2012;2:227-51.

Cryer B, Feldman M. Cyclooxygenase-1 and cyclooxygnease-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med 1998;104:413–21.

Shah V, Jain H, Jethva K, Patel P. Microsponge drug delivery: a review. Int J Res Pharm Sci 2010;1:212-8.

Kilicarslan M, Baykara T. The effect of the drug/polymer ratio on the properties of verapamil HCl loaded microspheres. Int J Pharm 2003;252:99–109.

Karthika R, Elango K, Kumar K, Rahul K. Formulation and evaluation of lornoxicam microsponge tablets for the treatment of arthritis. Int J Pharm Innovations 2013;3:29-40.

Al-Khedairy E. Effect of additives on the solubility and dissolution of piroxicam from prepared hard gelatin capsule. Iraqi J Pharm Sci 2012;21:117-22.

Patel S, Patel N. Development of directly compressible co-processed excipient for dispersible tablets using 32 full factorial design. Int J Pharm Pharm Sci 2009;1:125-48.

Bodmeier R, Chen H. Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen. J Controlled Release 1989;10:167-75.

Nief R, Hussein A. Preparation and evaluation of meloxicam microsponges as a transdermal delivery system. Iraqi J Pharm Sci 2014;23:62-74.

Ravi R, Kumar S. Standardization of process parameters involved erythromycin microsponges by quasi-emulsion solvent diffusion method. Int J Pharm Dev Technol 2013;3:28-34.

United States pharmacopoeia. The USP Convention; 2007.

Mohapatra A, Parikh R, Gohel M. Formulation, development and evaluation of patient-friendly dosage forms of metformin, part-I: Orally disintegrating tablets. Asian J Pharm 2008;2:167-71.

Agarwal V, Kothari B, Moe D, Khankari R. Drug delivery: fast-dissolve systems. Encyclopedia Pharm Technol 2007;3:1104-14.

Ramesh J, Reddy V, Rao G. Formulation, and evaluation of oral disintegrating tablet of labetalol hydrochloride. Int J Pharm Sci 2010;2:488-95.

Nagabhushanam M. Formulation studies on cyclodextrin complexes of piroxicam. Rasayan Chem J 2010;3:314-20.

Grozdanis M, Bolger M, Langguth P. Application of gastrointestinal simulation for extensions for biowaivers of highly permeable compounds. AAPS J 2008;10:213-26.

Perumal D. Microencapsulation of Ibuprofen and Eudragit RS100 by the emulsion solvent diffusion technique. Int J Pharm 2001;218:1-5.

Saboji J, Manvi V, Gadad P, Patel D. Formulation and evaluation of ketoconazole microsponge gel by quasi-emulsion solvent diffusion. J Cell Tissue Res 2011;11:2691-6.

Maiti S, Kaity S, Ray S, Sa B. Development, and evaluation of xanthan gum-facilitated ethyl cellulose microsponges for controlling percutaneous delivery of diclofenac sodium. Acta Pharm 2011;61:257–70.

Orlu M, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm 2006;318:103–17.

Hussain H, Dhyani A, Juyal D, Bahuguna A. Formulation and evaluation of gel-loaded microsponges of diclofenac sodium for topical delivery. Pharm Innovation J 2014;3:58-63.

Abdelmalak N, El-Menshawe S. A new topical fluconazole microsponge loaded hydrogel: preparation and characterization. Int J Pharm Sci 2012;4:460-8.

Sareen R, Kavita K, Jain N, Dhar K. Curcumin loaded microsponges for colon targeting in inflammatory bowel disease: Fabrication, optimization, in vitro and pharmacodynamic evaluation. BioMed Res Int 2014;2014:1-7.

Pawar A, Gholap A, Kuchekar A, Bothiraja C, Mali A. Formulation and evaluation of optimized oxybenzone microsponge gel for topical delivery. J Drug Delivery 2015;2015:1-9.

Sonal S, Singh R, Prajapati S. Formulation and evaluation of prednisolone loaded microsponges for colon drug delivery: In-vitro and pharmacokinetic study. Int J Pharm Sci Res 2014;5:1994-2005.

Yang Y, Chang T. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by a double emulsion solvent extraction evaporation method. Biomaterials 2001;22:231-41.

Nokhodchi A, Jelvehgari M, Siahi R, Mozafari R. Factors affecting the morphology of benzoyl peroxide microsponges. Micron 2007;38:834–40.

Mainardes R, Evangelista C. PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution. Int J Pharm 2005;290:137-44.

Srivastava R, Pathak K, Kumar D. Colonic luminal surface retention of meloxicam microsponges delivered by erosion based colon-targeted matrix tablet. Int J Pharm 2012;427:153–62.

Osmani R, Nagesh H, Kulkarni A, Bhargav R, Bhosale H. A new cornucopia in topical drug delivery: microsponge technology. Asian J Pharm Sci Technol 2014;4:48-60.

Harsh S, Patel K, Padhyay U. Formulation and evaluation of controlled release colon targeted microsponge of aceclofenac. Pharm Innovation J 2014;3:81-7.

FDA U. Guidance for industry: dissolution testing of immediate-release solid oral dosage forms. Food and drug administration, a center for drug evaluation and research (CDER); 1997.

Sayed H, Auda S, Mahmoud M, Abd El-Rasoul S, Saleh K. Formulation and physicochemical characterization of piroxicam-containing polymer films bull. Pharm Sci 2010;33:33-42.

Manohara C, Sanganal J, Prem Kumar P, Swamy B, Phani A. Improved dissolution rate of piroxicam by fusion solid dispersion technique. SCI Technol Arts Res J 2014;3:44-7.

Adibkia K, Shadbad S, Nokhodch A, Javadzedeh A, Jalali B, Barar J, et al. Piroxicam nanoparticles for ocular delivery: physicochemical characterization and implementation in endotoxin-induced uveitis. J Drug Targeting 2007;15:407-16.

Karatas A, Yüksel N, Baykara T. Improved solubility and dissolution rate of piroxicam using gelucire 44/14 and labrasol. IL Farmaco 2005;60:777–82.

Banker G, Rhodes C, Modern Pharmaceutics; 2002;121. p. 437.

Comoglu T, Gonul N, Baykara T. The effects of pressure and direct compression on tableting of microsponges. Int J Pharm 2002;242:191–5.

Patel H, Patel J, Patel K, Patel R. Studies on the formulation and in vitro evaluation of fast dissolving tablets of domperidone. Int J Pharm Sci 2010;2:470-6.

Mohamed M, Talari M, Tripathy M, Abdul majeed A. Pharmaceutical applications of crospovidone: a review. Int J Drug Formulation Res 2012;3:13-28.

Patel D, Patel M, Shah R, Jogani L, Balapatel I. Studies in the formulation of orodispersible tablets of rofecoxib. Indian J Pharm Sci 2004;66:621-5.

Gohel M, Parikh R, Brahmbhatt B, Shah A. Improving the tablet characteristics and dissolution profile of ibuprofen by using a novel co-processed super disintegrant: a technical note. AAPS PharmSciTech 2007;8:1-6.

Balasubramaniam J, Bindu K, Rao V, Ray D, Haldar R, Brzeczko A. Effect of super disintegrants on the dissolution of cationic drugs. Dissolution Technol 2008;10:18-25.

Balasubramaniam J, Bee T. Influence of super disintegrants on the rate of drug dissolution from oral solid dosage forms. Pharma tech com; 2009.

Zulfiker A, Islam K, Islam R, Azam K, Reza M. Formulation development using maize starch & avicel pH 101 as disintegrating agents and their effect on physical characteristics and in vitro release profile. Int J Pharm Res 2011;2:2136-41.



How to Cite

Rajab, N. A., and M. S. Jawad. “FORMULATION AND IN VITRO EVALUATION OF PIROXICAM MICROSPONGE AS A TABLET”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 2, Feb. 2016, pp. 104-1,



Original Article(s)