• Hetal Patel
  • Sonia Pandey
  • Vihari Patel
  • Ritesh Shah
  • Sanjay Tiwari Maliba Pharmacy College, Uka Tarsadia University, Bardoli Mahuva Road, Surat, Gujarat, India 394350


Objective: The objective of the present research work is to develop compression coated tablet of ketoprofen as a pulsatile release system for treatment of rheumatoid arthritis.

Methods: Core tablets of ketoprofen were prepared using the wet granulation method and evaluated for appearance, hardness, friability, weight variation, thickness, disintegration time and % drug release. Core tablets were coated with Eudragit S100 and Eudragit L100 by compression coating method to achieve desired lag time. The blends of core and coating materials were evaluated for bulk density, tapped density, Hausner's ratio, % Compressibility index and angle of repose. Compression coated tablets were evaluated for appearance, hardness, friability, weight variation, thickness and % drug release.

Results: Core tablets, as well as compression coated tablets, showed acceptable Pharmaco technical properties. Optimized core tablets were disintegrated within 15s due to the effectiveness of super disintegrant, sodium starch glycolate. Dissolution studies of compression coated tablets in media with different pH (1.2, 6.8, and 7.4) showed that drug release could be modulated by changing the concentration of EudragitL100 and Eudragit S100. The optimized batch exhibited 80% drug release up to 6 h with a 4 h lag time. Stability study of the optimized formulation indicated no significant change in appearance, physical parameters, drug content and drug release profile at accelerated conditions for two months.

Conclusion: compression coated tablet of ketoprofen was successfully developed to achieve burst drug release after specific lag time.

Keywords: Chronomodulated drug delivery, Pulsatile release, Compression coated tablets, Lag time


Download data is not yet available.


Gohel MC, Parikh RK, Brahmbhatt BK, Shah AR. Preparation and assessment of novel co processed super disintegrant consisting of crospovidone and sodium starch glycolate: a technical note. AAPS PharmSciTech 2007;8:1-7.

Tranyor K, Newton DW, Hrushesky JM, Reiter RJ. A pharmacist’s primer on chronotherapeutics. Am Pharm 1992;32:261-9.

Sajan J, Cinu TA, Chacko AJ, Litty J. Chronotherapeutics and chronotherapeutic drug delivery systems. Trop J Pharm Res 2009;8:467–75.

Kikuchi A, Okano T. Pulsatile drug release control using hydrogels. Adv Drug Delivery Rev 2002;549:53-77.

Santini JT, Richards AC, Scheidt R, Cima MJ, Langer R. Microchips as controlled drug delivery devices. Angewantde Chem Int Edition 2000;39:2396-407.

James HP, Sara L, Samuel B, Norman FS, John MM, Jonathan C, et al. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nat Biotech 2006;24:437-8.

Ritschel WA, Forusz H. Chronopharmacology: a review of drugs studied. Methods Find Exp Clin Pharmacol 1994;16:57-75.

Ura J, Shirachi D, Ferrill M. The chronotherapeutic approach to pharmaceutical treatment. California Pharm 1992;23:46-53.

Yang SY, Yang JA, Kim ES, Jeon G, Oh EJ, Choi KY, et al. Single-file diffusion of protein drugs through cylindrical nanochannels. Am Chem Soc Nano 2010;4:3817-22.

Shah R, Patel S, Patel H, Pandey S, Shah S, Shah D. Formulation development of carvedilol compression coated tablet. Pharm Dev Technol 2013;18:906-15.

Lachman L, Speiser P, Sywestrowicz H. Compression coated tablets 1. Measurement and factors influencing core centeration. Am J Pharmacol Sci 1962;52:379-90.

Nazir SU, Khan RU, Amer M, Nadeem M, Sultana M, Naeem Qaisar M, et al. Formulation development, evaluation and anti-inflammatory effects of ketoprofen cream on rheumatoid arthritis patients. Int J Curr Life Sci 2013;3:132-6.

Rheumatoid arthritis–Symptoms. Available from: http:// www. nhs.uk/ Conditions/Rheumatoid-arthritis/Pages/ Symptoms. aspx. [Last accessed on 10 Aug 205].

Bodempudi S, Deveswaran R, Bharath S, Basavaraj BV, Madhavan V. Release characteristics of drugs from cross-linked tamarind seed polysaccharide matrix tablets. Pharm Sinica 2011;2:67-76.

Khadabadi S, Chishti N, Khan M, Tadvee A. Formulation and evaluation of press coated tablet of Ketoprofen a chrono-therapeutic approach. Int J Pharm Pharm Sci 2013;5:733-40.

Rane Ab, Gattani SG, Kadam VD, Tekade AR. Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers. Chem Pharm Bull 2009;57:1213-7.

Fan TY, Wei SL, Yan WW, Chen DB, Li J. An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets. J Controlled Release 2001;77:245-51.

Pandey S, Mehta P, Patel H, Shah R, Gupta A, Mishra A. Novel time and site specific tablets in capsule†system for nocturnal asthma treatment. J Pharm Invest 2014;44:381-90.

Indian Pharmacopeia. Monograph of Ketoprofen. The Indian Pharmacopoeia Commission, Ghaziabad; 2010.

United States Pharmacopoeia 30-National Formulatory 25. Chapter 1174: Powder flow. United states Pharmacopeial Convention; 2008.

Wells JI, Aulton ME. Preformulation. Pharmaceutics: The Science of Dosage Form Design. Edinburgh: Churchill Livingstone; 1998.

ICH guidelines. Q1A-Q1F. Available from: www.ich.org/ cache/compo/363-272-1.html. [Last accessed on 10 Aug 2015].

Anthony C, Osseltonm, Widdop B. Clarke’s analysis of drugs and poisons. London: Pharmaceutical Press; 2005.

Consiglieri VO, Mourao S, Sampaio M, Granizo P, Garcia P, Martinello V, et al. Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules. Braz J Pharm Sci 2010;46:115-20.

Patel P, Telange D, Sharma N. Comparison of different granulation techniques for lactose monohydrate. Int J Pharm Sci Drug Res 2011;3:222-5.

Sharma D. Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders. Int Scholarly Res Not 2013;1:8.

Mohammed S, Bhargavi C, Harish G, Riyajune A, Yasmeen M, Muralikrishna C, et al. Effect of different disintegrants on ciprofloxacin conventional tablets. Indian J Res Pharm Biotechnol 2013;1:281-7.

Setty CM, Radhika M, Gupta VRM, Reddy MVR, Jithan AV. Effect of tablet processing and formulation factors on disintegration and dissolution of aceclofenac tablets. Int J Pharm Sci Nanotechnol 2011;3:1240-51.

Cheng G, An F, Zou MJ, Sun J, Hao HH, He YX. Time-and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid. World J Gastroenterol 2004;10:1769-74.

Dangi P, Gadad A, Kulkarni A, Mastiholimath V. Time and pH dependent colon specific, pulsatile delivery of theophyline for nocturnal ashthma. Int J Pharm 2007;328:49-56.

Mehta R, Chawda A, Sharma P, Pawar P. Formulation and in vitro evaluation of Eudragit S-100 coated naproxen matrix tablets for colon-targeted drug delivery system. J Adv Pharm Technol Res 2013;4:31–41.

Panigrahi AK, Annapurna MM, Himashankar K. Microspheres of 5-fluorouracil for colon targeting. Int J Pharm Pharm Sci 2012;4:215-20.



How to Cite

Patel, H., S. Pandey, V. Patel, R. Shah, and S. Tiwari. “PULSATILE RELEASE OF KETOPROFEN FROM COMPRESSION COATED TABLETS USING EUDRAGIT® POLYMERS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 2, Feb. 2016, pp. 224-9, https://journals.innovareacademics.in/index.php/ijpps/article/view/9158.



Original Article(s)