ANTIDYSLIPIDEMIC ACTIVITY OF KATUK LEAVES SAPONINS FRACTION (SAUROPUS ANDROGYNUS (L.) MERR) IN RATS INDUCED WITH FAT-RICH DIET
Abstract
Objective: The present study was to evaluate the anti dyslipidemic activity and the atherogenic indicator of saponin compound from katuk leaves (Sauropus androgynus (L).
Methods: This compound separated from Katuk leaves crude extract by column chromatography (a mobile phase: silica GF 254; mobile phase = gradient polarity of solvent (chloroform: methanol = 1:9-9:1). Male Wistar rats were fed with fat-rich diet (15% pig fats, 5% duck egg yolk) for 30 d to increase its total cholesterol level, triglyceride, LDL and to decrease blood HDL level compared to normal lipid level. Saponins fraction of Katuk leaves dose 10 and 30 mg/kg BW was given for 2 w and then its lipid level in blood was measured. Lipid level difference from each group was analyzed statistically.
Results: Total cholesterol, triglyceride, LDL and HDL level from a group of rats that were given saponins fraction of Katuk leaves was significantly different with negative control rats group and was not significantly different compared to normal control rats. Saponins fraction was able to reduce CRR, AR, and IAP value in treated rats.
Conclusion: Katuk leaves saponins fraction can become an anti dyslipidemic and also prevent the cardiovascular disorder in Wistar male rats.
Keywords: Dyslipidemia, Katuk leaves saponins fraction, Lipid profileÂ
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References
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