ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY PROPERTIES OF ESSENTIAL OIL AND AQUEOUS EXTRACT OF ORMENIS MIXTA L. IN RODENTS
Abstract
Objective: Ormenis mixta L. (Asteraceae) is a traditional herbal medicine widely used as a mild sedative, spasmolytic and antibacterial agent. This paper aimed to examine possible anti-inflammatory and antinociceptive effects of Ormenis mixta L. in rodents.
Methods: Anti-inflammatory effect of Ormenis mixta L. was investigated with the carrageenan and experimental trauma-induced hind paw edema tests. Ormenis mixta L. essential oil (OMEO) by gavage at 100 and 200 mg/kg and aqueous extract (OMAE) at 200 and 400 mg/kg, were administered and compared with indomethacin, and control group. Antinociceptive effects of both extracts were evaluated using acetic acid-induced writhing and tail immersion tests and compared with standard drug (morphine and aspirin).
Results: It was found that pretreatment with OMEO and OMAE significantly (P<0.05) reduced paw swelling and diminished the nociceptive response in rodents.
Conclusion: Ormenis mixta L. essential oil and aqueous extract have a potent anti-inflammatory and an antinociceptive properties
Keywords: Ormenis mixta L. Anti-inflammatory, Antinociceptive, Morphine, Carrageenan
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References
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