EVALUATION OF IN-VITRO ANTIHELMINTIC PROPERTIES OF THE EXTRACT OF RUSSELIA EQUISETIFORMIS (SCHLECHT. AND CHAM.) SCROPHULARIACEAE
Keywords:
Russelia equisetiformis, Pheretima posthuma, Anthelmintic, Solvent extractsAbstract
Objective: The present study was aimed to evaluate the in vitro anthelmintic activity of Russelia equisetiformis leaves in comparison with anthelmintic drug Piperazine citrate.
Methods: In vitro Anthelmintic activity of different solvent extracts (petroleum ether, chloroform, ethyl acetate and methanol) of Russelia equisetiformis were carried out on mature Pheretima posthuma.
Results: The results of the study revealed that all the solvent extracts produced a significant anthelmintic activity in a dose-dependent manner. Methanol extract offered a good anthelmintic activity at 15 mg/ml concentration, where the time of paralysis was 15 and death was observed at 27 min, followed by ethyl acetate extract. The negative control DMF did not show any activity and positive control standard piperazine citrate recorded death at 13 min and paralysis at 10 min.
Conclusion: Despite ample evidence of anthelmintic properties of R. equisetiformis through validated experimental data, further studies on Russelia equisetiformis is required to recognize the active principle responsible for the anthelmintic activity.
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