EVALUATION OF ANTIDIABETIC AND ANTI HYPERLIPIDEMIC ACTIVITIES OF MACARANGA TANARIUS IN RATS FEED WITH HIGH GLUCOSE-FRUCTOSE DIET
Keywords:
Macaranga tanarius, antidiabetic, Antihiperlipedmia, Glucose-fructoseAbstract
Objective: Macaranga tanarius showed a potent α–glucosidase inhibitors that may benefit diabetes treatment. The hexane-ethanol fraction of methanol extract of Macaranga tanarius was investigated for antidiabetic, and anti hiperlidemia activity in rats feed with high glucose-fructose diet.
Methods: After induced with high glucose-fructose diet for 42 d, the rats were treated with the hexane-ethanol fraction of methanol extract of Macaranga tanarius at doses of 34.2, 78.5, 137 mg/kg per oral once in a day for 5 d and high glucose-fructose diet consecutively. Fasting blood glucose, cholesterol, triglyceride, HDL and LDL concentration were evaluated at the next day after treatment.
Results: The 5 d administration of hexane-ethanol fraction of methanol extract of Macaranga tanarius did not produce any significant difference in any of the assigned parameters between the diet and all dose groups.
Conclusion: The hexane-ethanol fraction of methanol extract of Macaranga tanariusat all level has not antidiabetic and anti hiperlidemia activity in rats feet with high glucose-fructose diet.
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References
Su DHW, Yeo KT. Diabetic retinopathy and serum lipids. Singapore Med J 2000;41:295-7.
World Agroforestry Centre. Botanic Nomenclature to Agroforestry trees: Macarangatanarius. World Agroforestry Centre; 2011. Available: http://www.worldagroforestrycentre. org/sea/Products/AFDbases/af/asp/SpeciesInfo. asp?SpID=1092. [Last accessed on 12 Mar 2011].
Phommart S, Sutthivaiyakit P, Chimnoi N, Ruchirawat S, Sutthivaiyakit S. Constituents of the leaves of macarangatanarius. J Nat Prod 2005;68:927-30.
Matsunami K, Takamori I, Shinzato T, Aramoto M, Kondo K, Otsuka H. Radical-Scavenging activities of new mega stig mane glucosides from Macarangatanarius(L.) MÃœLL.-ARG. Chem Pharm Bull 2006;54:1403-7.
Matsunami K, Otsuka H, Kondo K, Shinzato T, Kawahata M, Yamaguchi K. Absolute configuration of (+)-pinoresinol 4-O-[6-O-galloyl]-β-D-glucopyranoside, macaranga sides E, and F isolated from the leaves of Macarangatanarius. Phytochemistry 2009;70:1277-85.
Puteri MG, Kawabata J. Novel α-glucosidase inhibitors from macarangatanarius leaves. Food Chem 2010;123:384-9.
Elliott SS. Leim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002;76:911-22.
Nugroho AE. Review: an animal model of diabetes mellitus: pathology and mechanism of some diabetogenic. Biodiversitas 2006;7:378-82.
Saleh DO, El-Awdan SA, Nofel SM, El-Eraky WI, El-Khatib AS, Kenawy SA. Estrogens improve the cardiovascular alterations in fructose-induced insulin resistant ovariactoized rats. Int J Pharm Pharm Sci 2015;7:241-7.
Srivastava SP, Mishra A, Lakshmi V, Tamrakar AK, Srivastava MN, Srivastava AK. Antidiabetic and antidyslipidemic activity of ethyl acetate fractions of xylocarpusgranatum and xylocarpusmolluccensis on high fructose high fat and high sucrose hig fat fed-low dosed streptozotocin-treated diabetic rats. Int J Pharm Pharm Sci 2015;7:537-43.
Rashid S, Watanabe T, Sakaue T, Lewin G. Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity. Chem Biochem 2003;36:421-9.
Huang D, Dhawan T, Young S, Yong WH, Boros LG, Heaney AP. Fructose impairs glucose-induced hepatic triglyceride synthesis. Lipids Health Dis 2011;10:20.
DeBosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem 2014; 289:10989-98.
Padiya R, Khatua TN, Bagul PK, Kucha M, Banerjee SK. Garlic improves insulin sensitivity and associated metabolic syndromes in fructose-fed rats. Nutr Metab 2011;8:53.
Handayani MT, Hendra P. Pengaruh pemberian ekstrak metanol-air daun Macarangatanarius L. terhadap penurunan kadar glukosa darahpada tikus yang terbebani glukosa. Jurnal Farmasi Sains dan Komunitas 2013:10:37-42.