AN OVERVIEW ON THE BIOLOGICAL PERSPECTIVES OF NARDOSTACHYS JATAMANSI

Authors

  • S. Nithya SASTRA University
  • Meenakshi Sundaram Muthuraman Department of Biotechnology, School of Chemical and Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur 613401, Tamilnadu, India

Keywords:

Biological perspectives, Nardostachys jatamansi

Abstract

Nardostachys jatamansi is a flowering plant of the Valerianaceae family, which is a native plant of the Indian and Nepal Himalaya. It is found from 2200m to 5000m asl. in random forms. It is also called as spikenard, nard, nardin, or muskroot used in the formulation of traditional Ayurvedic medicines as well as modern herbal preparations for curing various ailments. The plant abounds in sesquiterpenes predominantly; jatamansone and nardostachone. Nardostachys jatamansi possesses biological properties such as antioxidant, antimicrobial, anticholinesterase, oxidative stress, antidepressant and anti-inflammatory activities. It is also useful in the management of insomnia and CNS disorders. This study has detailed information regarding the various activities and mainly focuses on the pharmacological activity of Nardostachys jatamansi.

 

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References

Ncube N, Afolayan SAJ, Okoh AI. Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and future trends. Afr J Biotechnol 2008;7:1797-806.

Mansoor Shazia, Moht Ali Saadia, Fatima Jasmine, Jamal Mohammad Arif, Mustafa Huma. Antimicrobial screening of some medical plant extracts. Int J Res Ayurveda Pharm 2011;2:1258-64.

Fatma Pehlivan Karakas, Arzu Yildirim, Arzu Turker. Biological screening of various medicinal plant extracts for antibacterial and antitumor activities. Turkish J Biol 2012;36:641-52.

Kumar GP, Anil kumar KR, Naveen S. Phytochemicals having neuroprotective properties from dietary sources and medicinal herbs. Pharmacognosy 2015;7:1-17.

Airi S, Rawal RS, Dhar U, Purohit AN. Assessment of availability and habitat preference of Jatamansi-A critically endangered medicinal plant of west Himalaya. Curr Sci 2000;79:1467-71.

Vineet S, Priyanka D, Sharad S, Rawat AKS. Botanical standardization of the jatamansi, their substitute and adulterant species. Indian J Traditional Knowledge 2011;10:599-603.

Subedi BP, Shrestha R. Plant profile: jatamansi (Nardostachys grandiflora). Himalayan Bioresources 1999;3:14-5.

Shilpee Chaudhary, Kodangala Subraya Chandrashekar, Karkala Sreedhara Ranganath Pai, Manganahalli Manjunath Setty, Raviraj Anand Devkar, Neetinkumar Dnyanoba Reddy, et al. Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma. BMC Complement Altern Med 2015;15:1-13.

Mathew M, Subramanian S. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders. Plos One 2014;9:e86804.

Mishra AP, Saklani S, Milella L, Tiwari P. Formulation and evaluation of herbal antioxidant face cream of Nardostachys jatamansi collected from Indian Himalayan region. Asian Pac J Trop Biomed 2014;4:5679-82.

Pandey MM, Katara A, Pandey G, Rastogi S, Rawat AKS. An important indian traditional drug of ayurveda jatamansi and its substitute bhootkeshi: chemical profiling and antioxidant activity. J Evidence-Based Complementary Altern Med 2013. Doi:10.1155/2013/142517. [Epub 21 Mar 2013].

Dugaheh MA, Meisami F, Torabian Z, Sharififar F. Antioxidant effect and study of bioactive components of Valeriana sisymbriifolia and Nardostachys jatamansi in comparison to Valeriana officinalis. Pak J Pharm Sci 2013;26:53-8.

Sharma SK, Singh AP. In vitro antioxidant and free radical scavenging activity of Nardostachys jatamansi DC. J Acupuncture Meridian Studie 2012;5:112-8.

Parveen Z, Siddique S, Shafique M, Khan SJ, Khanum R. Volatile constituents, antibacterial and antioxidant activities of essential oil from Nardostachys jatamansi DC. roots. Pharmacologyonline 2011;3:329-37.

Rasheed AS, Venkataraman S, Jayaveera KN, Mohammed Fazil A, Yasodha KJ, Aleem MA, et al. Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats. Am J Clin Hypnosi 2011;53:127-36.

Kumari S, Rama Rao M, Bhaskar Reddy I, Rama Rao V. Study on radical scavenging activity and analysis of bioactive compounds in selected Indian medicinal plants. Biosci Biotechnol Res Asia 2010;7:913-8.

Nazmun Lyle, Antony Gomes, Tapas Sur, Santanu Munshi, Suhrita Paul, Suparna Chatterjee, et al. The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome. Behav Brain Res 2009;202:285-90.

Lyle N, Bhattacharyya D, Sur TK, Munshi S, Paul S, Chatterjee S, et al. Stress modulating the antioxidant effect of Nardostachys jatamansi. Indian J Biochem Biophys 2009;46:93–8.

Maitinuer Maiwulanjiang, Jianping Chen, Guizhong Xin, Amy GW Gong, Abudureyimu Miernisha, Crystal YQ Du, et al. The volatile oil of Nardostachyos Radix et Rhizoma inhibits the oxidative stress-induced cell injury via reactive oxygen species scavenging and Akt activation in H9c2 cardiomyocyte. J Ethnopharmacol 2014;153:491-8.

Dhuna K, Dhuna V, Bhatia G, Singh J, Kamboj SS. Cytoprotective effect of methanolic extract of Nardostachys jatamansi against hydrogen peroxide-induced oxidative damage in C6 glioma cells. Acta Biochim Pol 2013;60:21-31.

Lyle N, Chakrabarti S, Sur T, Gomes A, Bhattacharyya D. Nardostachys jatamansi protects against cold restraint stress induced central monoaminergic and oxidative changes in rats. Neurochem Res 2012;37:2748-57.

Badruzzaman Khan M, Nasrul Hoda, Tauheed Ishrat, Saif Ahmad, Moshahid Khan, Ajmal Ahmad, et al. Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment. J Neurol Sci 2012;33:1011-20.

Suchetha Kumari N, Madhu LN. Protective effect of Nardostachys jatamansi on radiation-induced anxiety and oxidative stress. Biomedicine 2012;32:337-41.

Ali A, Dua Y, Siddiqui AW, Sultana S, Rafiullah MRM. Inhibition of benzoyl peroxide-induced cutaneous oxidative stress, toxicity, and ear edema in mice by Nardostachys jatamansi. Pharm Biol 2005;43:533-9.

Mathew M, Subramanian S. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders. PloS One 2014;9:e86804.

Karkada G, Shenoy KB, Halahalli H, Karanth KS. Differential effect of Nardostachys jatamansi rhizome extract on acetylcholinesterase in different regions of the brain in rats under chronic stress. Biomedicine 2011;31:13-21.

Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 2007;21:1142-5.

Vinutha B, Prashanth D, Salma K, Sreeja SL, Pratiti D, Padmaja R, et al. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity. J Ethnopharmacol 2007;109:359-63.

Li C, Wang MH. Nardostachys jatamansi (D. Don) DC prevents LPS-induced inflammation in RAW 264.7 macrophages by preventing ROS production and down-regulating inflammatory gene expression. Food Sci Biotechnol 2014;23:903-9.

Gi-Sang Bae, Kwang-Ho Heo, Sun Bok Choi, Il-Joo Jo, Dong-Goo Kim, Joon-Yeon Shin, et al. Beneficial effects of fractions of Nardostachys jatamansi on lipopolysaccharide-induced inflammatory response. J Evidence-Based Complementary Altern Med 2014. doi:10.1155/2014/837835. [Epub 30 Mar 2014].

Gi-Sang Bae, Sang-Wan Seo, Min-Sun Kim, Kyoung-Chel Park, Bon Soon Koo, Won-Seok Jung, et al. The root of Nardostachys jatamansi inhibits lipopolysaccharide-induced endotoxin shock. J Nat Med 2011;65:63-72.

Deepa B, Suchetha K, Rao S. Antidepressant activity of Nardostachys jatamansi in electron beam irradiated mice. Int J Res Ayurveda Pharm 2013;4:101-3.

Dhingra D, Goyal PK. Inhibition of MAO and GABA: probable mechanisms for the antidepressant-like activity of Nardostachys jatamansi DC. in mice. J Exp Biol 2008;46:212-8.

Chandrasekhar P, Lakshmi T, Suresh S. Bacterial reverse mutation test with Nardostachys jatamansi. Int J Pharm Pharm Sci 2013;5:5262-6.

Parveen Z, Siddique S, Shafique M, Khan SJ, Khanum R. Volatile constituents, antibacterial and antioxidant activities of essential oil from Nardostachys jatamansi DC. roots. Pharmacologyonline 2011;3:329-37.

Sohail T, Yaqeen Z, Imran H, Shaukat S, Atiq-Ur-Rahman. Antibacterial and antifungal screening of the root extracts of Nardostachys jatamansi. Pak J Sci Ind Res 2007;50:261-5.

Etebari M, Zolfaghari B, Jafarian-Dehkordi A, Rakian R. Evaluation of DNA damage of hydro-alcoholic and aqueous extract of Echium amoenum and Nardostachys jatamansi. J Res Med Sci 2012;17:782-6.

Patil RA, Hiray YA, Kasture SB. Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi. Indian J Pharmacol 2012;44:340-4.

Rao VS, Rao A, Karanth KS. Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats. J Ethnopharmacol 2005;102:351-6.

Shilpee Chaudhary, Kodangala Subraya Chandrashekar, Karkala Sreedhara Ranganath Pai, Manganahalli Manjunath Setty, Raviraj Anand Devkar, Neetinkumar Dnyanoba Reddy, et al. Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma. BMC Complementary Altern Med 2015;15:1-13.

Maitinuer Maiwulanjiang, Cathy WC Bi, Pinky SC Lee, Guizhong Xin, Abudureyimu Miernisha, Kei M Lau, et al. The volatile oil of Nardostachyos Radix et rhizoma induces endothelial nitric oxide synthase activity in HUVEC cells. PloS One 2015;10:e0116761.

Kasture SB, Mane Deshmukh RV, Arote SR. Non-linear dose-effect relationship in anxiolytic and nootropic activity of lithium carbonate and Nardostachys jatamansi in rats. Oriental Pharm Exp Med 2014;14:357-62.

Damodara KM Gowda, Lathika Shetty, Krissshna AP, Suchetha N Kumari, Ganesh Sanjeev, Naveen P. The efficacy of Nardostachys Jatamansi against the radiation-induced haematological damage in rats. J Clin Diagn Res 2013;7:982-6.

Jadhav PP, Jadhav NR, Hosmani AH, Patil S. Development and evaluation of in situ thermoresponsive nasal gel system for Nardostachys jatamansi. Pharm Lett 2013;5:113-25.

Naveen P, Suchetha Kumari N, Srinivasa G, Ramakrishna MK, Ramesh SR, Sanjeev G. In-vivo study of the ameliorative effect of Nardostachys jatamansi against electron beam induced cytogenetic damage. Drug Invent Today 2012;4:659-62.

Rasheed Ahemad S, Venkataraman S, Jayaveera KN, Javeed MY. Phytochemical, toxicological evaluation and anticataleptic activity of Nardostachys jatamansi. Asian J Pharm Clin Res 2012;5(Suppl 4):200-6.

Madhu LN, Suchetha Kumari N, Naveen P, Sanjeev G. Protective effect of Nardostachys jatamansi against radiation-induced damage at biochemical and chromosomal levels in swiss albino mice. Indian J Pharm Sci 2012;74:460-5.

Gi-Sang Bae, Kyoung-Chel Park, Bon Soon Koo, Il-Joo Jo, Sun Bok Choi, Ho-Joon Song, et al. Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases. Exp Ther Med 2012;4:533-7.

Bae GS, Kim MS, Park KC, Song HJ, Park SJ. Effect of a biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis. World J Gastroenterol 2012;18:3223-34.

Karkada G, Shenoy KB, Halahalli H, Karanth KS. Nardostachys jatamansi extract prevents chronic restraint stress-induced learning and memory deficits in a radial arm maze task. J Nat Sci Biol Med 2012;3:125-32.

Bae Gi-Sang, Park Kyoung-Chel, Koo Bon-Soon, Choi Sun-Bok, Jo Il-Joo, Choi Chang-Min, et al. The inhibitory effects of Nardostachys jatamansi on alcoholic chronic pancreatitis. J Biochem Mol Biol 2012;45:402-7.

Rezaie A, Pashazadeh M, Ahmadizadeh Ch, Jafari B, Jalilzadeh HM. Study of sedative and anxiolytic effect of an herbal extract of Nardostachys jatamansi in comparison with diazepam in rats. J Med Plants 2010;9:169-74.

Rahman H, Muralidharan P. Nardostachys jatamansi DC protects from the loss of memory and cognition deficits in sleep deprived alzheimer's disease (AD) mice model. Int J Pharm Sci Rev Res 2010;5:160-7.

Mi-Young Song, Ui-Jin Bae, Bong-Hee Lee, Kang-Beom Kwon, Eun-A Seo, Sung-Joo Park, et al. Nardostachys jatamansi extract protects against cytokine-induced-cell damage and streptozotocin-induced diabetes. World J Gastroenterol 2010; 16:3249-57.

Bae GS, Park HJ, Kim DY, Song JM, Kim TH, Oh HJ, et al. Nardostachys jatamansi protects against cerulein-induced acute pancreatitis. Pancreas 2010;39:520-9.

Rasheed AS, Venkataraman S, Jayaveera KN, Mohammed FA, Mohammed I, Krishna Y. Effect of hydro-alcoholic root extract of Nardostachys jatamansi on haloperidol induced parkinsonism in wistar rats. Pharmacologyonline 2009;2:1145-54.

Laishram D, Kumar R, Sandhu JS. Effects of strength training and jatamansi on reducing hand tremor amongst archers. Archivos Venezolanos Farmacologia Terapeutica 2008;27:105-9.

Subashini R, Ragavendran B, Gnanapragasam A, Kumar Yogeeta S, Devaki T. Biochemical study on the protective potential of Nardostachys jatamansi extract on lipid profile and lipid metabolizing enzymes in doxorubicin intoxicated rats. Pharmazie 2007;62:382-7.

Subashini R, Gnanapragasam A, Senthilkumar S, Yogeeta SK, Devaki T. Protective efficacy of Nardostachys jatamansi (Rhizomes) on mitochondrial respiration and lysosomal hydrolases during doxorubicin-induced myocardial injury in rats. J Health Sci 2007;53:67-76.

Joshi H, Parle M. Nardostachys jatamansi improves learning and memory in mice. J Med Food 2006;9:113-8.

Subashini R, Yogeeta S, Gnanapragasam A, Devaki T. Protective effect of Nardostachys jatamansi on oxidative injury and cellular abnormalities during doxorubicin-induced cardiac damage in rats. J Pharm Pharmacol 2006;58:257-62.

Muzamil Ahmad, Seema Yousuf, Badruzzaman Khan M, Nasrul Hoda, Abdullah Shafique Ahmad, Mubeen Ahmad Ansari, et al. Attenuation by Nardostachys jatamansi of 6-hydroxy-dopamine-induced parkinsonism in rats: behavioral, neurochemical, and immunohistochemical studies. Pharmacol Biochem Behav 2006;83:150-60.

Salim S, Ahmad M, Zafar KS, Ahmad AS, Islam F. Protective effect of Nardostachys jatamansi in rat cerebral ischemia. Pharmacol Biochem Behav 2003;74:481-6.

Ali S, Ansari KA, Jafry MA, Kabeer H, Diwakar G. Nardostachys jatamansi protects against liver damage induced by thioacetamide in rats. J Ethnopharmacol 2000;71:359-63.

Prabhu V, Sudhakar Karanth K, Rao A. Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain. Planta Med 1994;60:114-7.

Rekha K, Ranga Rao R, Richa Pandey, Kothakonda Rajendra Prasad, Katragadda Suresh Babu, Janakiram R Vangala, et al. Two new sesquiterpenoids from the rhizomes of Nardostachys jatamansi. J Asian Nat Prod Res 2013;15:111-6.

Jha SV, Bhagwat AM, Pandita NS. Pharmacognostic and phytochemical studies on the rhizome of Nardostachys jatamansi DC. using different extracts. Pharmacogn Res 2012;4:16-22.

Mallavadhani UV, Panigrahi R, Pattnaik B. A rapid and highly sensitive UPLC-QTOF MS method for quantitative evaluation of Nardostachys jatamansi using Nardin as the marker. Biomed Chrom 2011;25:902-7.

Gottumukkala VR, Annamalai T, Mukhopadhyay T. Phytochemical investigation and hair growth studies on the rhizomes of Nardostachys jatamansi DC. Pharmacogn Mag 2011;7:146-50.

Rao GV, Annamalai T, Mukhopadhyay T. Nardal, a new sesquiterpene aldehyde from the plant, Nardostachys jatamansi DC. Indian J Chem Br 2008;47:163–5.

Chatterjee A, Basak B, Datta U, Banerji J, Neuman A, Prange T. Studies on the chemical constituents of N. jatamansi DC (Valerianaceae). Indain J Chem Br 2005;44:430–3.

Asima Chatterjee, Bidyut Basak, Munmun Saha, Utpal Dutta, Chaitali Mukhopadhyay, Julie Banerji, et al. Structure and stereochemistry of nardostachysin, a new terpenoid ester constituent of the rhizomes of Nardostachys jatamansi. J Nat Prod 2000;63:1531-3.

Bagchi A, Oshima Y, Hikino H. Jatamols A and B: sesquiterpenoids of Nardostachys jatamansi roots. Planta Med 1991;57:282-3.

Bagchi A, Oshima Y, Hikino H. Spirojatamol, a new skeletal sesquiterpenoid of Nardostachys jatamansi roots. Tetrahedron 1990;46:1523-30.

Sastry SD, Maheswari ML, Chakravarti KK, Bhattacharyya SC. Terpenoids-CVII. The structure of nardostachone. Tetrahedron 1967;23:2491-3.

Sastry SD, Maheswari ML, Chakravarti KK, Bhattacharyya SC. Terpenoids-CVI. The structure of calarenol. Tetrahedron 1967;23:1997-2000.

Shanbhag SN, Mesta CK, Maheshwari ML, Bhattacharyya SC. Terpenoids-LXXV. Constituents of Nardostachys jatamansi and synthesis of (±) dihydrosamidin and visnadin from jatamansin. Tetrahedron 1965;21:3591-7.

Shanbhag SN, Mesta CK, Maheshwari ML, Paknikar SK, Bhattacharyya SC. Terpenoids-LII. Jatamansin, a new terpenic coumarin from Nardostachys jatamansi. Tetrahedron 1964;20:2605-15.

Singh V, Ali M, Upadhyay S. Study of colouring effect of herbal hair formulations on graying hair. Pharmacogn Res 2015;7:259-62.

Shah JS, Goyal RK. Investigation of neuropsychopharmacological effects of a polyherbal formulation on the learning and memory process in rats. J Young Pharm 2011;3:119-24.

Thorat RM, Jadhav VM, Kadam VJ. Development and evaluation of polyherbal formulations for hair growth-promoting activity. Int J PharmTech Res 2009;1:1251-4.

Meera S, Gupta Atyam VSSS, Kumar NS. Immunomodulatory and antioxidant activity of a polyherbal formulation. Int J Pharm 2008;4:287-91.

Kolte AY, Waghmare SP, Mode SG, Handa A. Efficacy of indigenous herbal preparation on altered milk pH, somatic cell count and electrolyte profile in subclinical mastitis in cows. Vet World 2008;1:239-40.

Mishra S, Khanna VK, Kumar V. 5-HT2A receptor binding and antidepressant studies on Anximin®, a polyherbal formulation. Pharmacologyonline 2008;2:379-89.

Vasudevan M, Parle M. Evidence of anti-demential potential of Abana®: an indian ayurvedic poly-herbal formulation in rats. Pharmacologyonline 2008;1:439-54.

Dandagi P, Patil M, Mastiholimath V, Gadad A, Dhumansure R. Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants. Indian J Pharm Sci 2008;70:265-8.

Jagetia GC, Baliga MS, Aruna R, Rajanikant GK, Jain V. Effect of abana (a herbal preparation) on the radiation-induced mosrtality in mice. J Ethnopharmacol 2003;86:159-65.

Purnima, Meenakshi Bhatt, Preeti Kothiyal. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC-medicinal herb. J Pharmacogn Phytochem 2015;3:102-6.

Hoerster H, Ruecker G, Tautges. Valeranone content in the roots of Nardostachys jatamansi and valeriana officinalis. Phytochemistry 1977;16:1070-1.

Published

01-02-2016

How to Cite

Nithya, S., and M. S. Muthuraman. “AN OVERVIEW ON THE BIOLOGICAL PERSPECTIVES OF NARDOSTACHYS JATAMANSI”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 2, Feb. 2016, pp. 31-36, https://journals.innovareacademics.in/index.php/ijpps/article/view/9571.

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Review Article(s)