EVALUATION OF IN VITRO DISSOLUTION OF BENZNIDAZOLE AND BINARY MIXTURES: SOLID DISPERSIONS WITH HYDROXYPROPYLMETHYLCELLULOSE AND β-CYCLODEXTRIN INCLUSION COMPLEXES

Authors

  • Adley A. N. DE-Lima Laboratory for Pharmaceutical Technology and Biotechnology, Pharmaceutics Department, Federal University of Rio Grande do Norte–UFRN
  • Jose Lamartine Soares Sobrinho Quality Control for Medicines and Cosmetics NCQMC, Department of Pharmaceutical Sciences,, Federal University of Pernambuco–UFPE
  • Magaly Andreza Marques De-Lyra Quality Control for Medicines and Cosmetics NCQMC, Department of Pharmaceutical Sciences,, Federal University of Pernambuco–UFPE
  • Fabiana Licia Araujo Dos Santos Medicine Technology Laboratory–LTM, Department of Pharmaceutical Sciences, Federal University of Pernambuco–UFPE
  • Camila Bezerra Melo Figueiredo Quality Control for Medicines and Cosmetics NCQMC, Department of Pharmaceutical Sciences,, Federal University of Pernambuco–UFPE
  • Pedro Jose Rolim Neto Medicine Technology Laboratory–LTM, Department of Pharmaceutical Sciences, Federal University of Pernambuco–UFPE

Keywords:

Benznidazole, Solid dispersion, Inclusion complexes, Dissolution

Abstract

Objective: To increase the solubility/dissolution of benznidazole (BNZ) in water using two systems: solid dispersions (SD) with hydroxypropylmethylcellulose (HPMC) and β-cyclodextrin (β-CD) inclusion complexes (IC).

Methods: The samples were obtained by physical mixtures (PM), kneading (KN), evaporation (EV) and by spray-dryer (SY) atomization The analysis was based on results of in vitro dissolution and molecular modeling techniques.

Results: Molecular modeling showed that BNZ can form β-CD complexes in different ways such as in an aqueous solution or a vacuum. In vitro dissolution showed significant improvement in BNZ solubility in the PM, SD and IC, and also that the β-CD IC promoted better solubility than SD with HPMC.

Conclusion: Considering the data obtained, it is possible to consider the technique for the formation of β-CD IC as a more effective technique in promoting the improvement of BNZ solubility compared with getting SD with HPMC which, in turn, may increase the bioavailability of the drug and improve their pharmaceutical potential.

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Published

01-11-2015

How to Cite

DE-Lima, A. A. N., J. L. S. Sobrinho, M. A. M. De-Lyra, F. L. A. D. Santos, C. B. M. Figueiredo, and P. J. Rolim Neto. “EVALUATION OF IN VITRO DISSOLUTION OF BENZNIDAZOLE AND BINARY MIXTURES: SOLID DISPERSIONS WITH HYDROXYPROPYLMETHYLCELLULOSE AND β-CYCLODEXTRIN INCLUSION COMPLEXES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 11, Nov. 2015, pp. 371-5, https://journals.innovareacademics.in/index.php/ijpps/article/view/9693.

Issue

Vol 7, Issue 11, 2015

Section

Original Article(s)