THE ANALYSIS OF ANTIBIOTIC CONSUMPTION WITHIN THE TERTIARY HEALTHCARE INSTITUTION IN SERBIA DURING 10-YEAR PERIOD (2001-2010)

Authors

  • Jelena BRUSIC-RENAUD Section for Prevention and Control of Nosocomial Infections, Military Medical Academy, Belgrade, Serbia
  • Mirjana Antunovic Section for Prevention and Control of Nosocomial Infections, Military Medical Academy, Belgrade, Serbia
  • Vesna SULJAGIC

Abstract

Objective: To present conclusions related to the antibiotic drug consumption in one tertiary healthcare institution in Serbia in a 10-year period (2001-2010).

Methods: It has been analyzed the issue of antibiotics for prevention and treatment of patients hospitalized at the Military Medical Academy between 2001 and 2010. Antibiotic consumption was expressed as a number of Defined Daily Doses per 100 bed-days (DDD/100BD).

Results: Total antibiotic consumption ranged from 49.6 DDD/100BD in 2001 up to 60.4 DDD/100BD in 2005. The leading group of antibiotic was third-generation cephalosporins which accounted for 15.1 DDD/100BD of its maximum consumption in 2007. Ceftriaxone was the most frequently used.

Conclusion: Analysis of antibiotic consumption, and multidisciplinary approach, has a crucial importance for further survey of protocols compliance concerning the antibiotic consumption in one hospital.

Keywords: Antibiotics, Hospital consumption, ATC, DDD, Bacterial resistance.

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References

Mirović V. Antibiotici i osnovni principi njihove kliniÄke primene [Antibiotics and Basic Principles of Their Clinical Use]. Beograd: ÄŒigoja Å¡tampa; 2003.

Wax RG. editors. Bacterial resistance to antimicrobials. 2nd ed. Taylor and Francis Group. Boca Raton; 2008.

Knox K, Lawson W, Holmes A. Multidisciplinary antimicrobial management teams and the role of the pharmacist in the management of infection. In: Gould IM, Van der Meer JWM. editors. Antibiotic Policies: Theory and Practice. New York: Kluwer Academic Publishers; 2005. p. 227-49.

WHO Collaborating Centre for Drug Statistics Methodology, Guidelines for ATC classification and DDD assignment; 2009.

ATC/DDD INDEX. Available from: www.whocc.no/ atc_ddd_index. [Last accessed on 10 Oct 2015].

Information obtained in treatment service, indicators of medical statistics, Treatment Sector, Military Medical Academy, Belgrade; 2008.

VeliÄković-Radovanović R, Petrović J, Kocić B, Antić S, RanÄ‘elović G. Correlation between antibiotic consumption and bacterial resistance as a quality indicator of proper use of these drugs in inpatients. Vojnosanit Pregl 2009;66:307-12.

Borg AM, Zarb P, Ferech M, Goossens H. Antibiotic consumption in southern and eastern Mediterranean hospitals: results from the AR med project. J Antimicrob Chemother 2008;62:830-6.

Radonjić V, Äukić LJ, Stefanović D, TeÅ¡ić D. Antibiotics marketing and consumption in serbia. Arh Farm 2007;57:332-46.

ESAC Year Book; 2008. Available from: www.esac.ua.ac.be. [Last accessed on 10 Oct 2015].

Dimina E, Akermanis M, Dumpis U. Antibiotic consumption in latvian teaching hospital 2000-2008. Proc Latv Acad Sci 2009;63:253-6.

Borg AM, Zarb P. Consumption of antibiotics at st luke’s hospital. Malta Medical J 2006;18:33-8.

Søes L, Mølbak K, Strøbaek S, Truberg Jensen K, Torpdahl M, Persson S, et al. The emergence of Clostridium difficile PCR ribotype 027 in denmark-a possible link with the increased consumption of fluoroquinolones and cephalosporins? Eurosurveillance 2009;14:1-4.

Pepin J, Saheb N, Coulombe MA, Alary MA, Corriveau MP, Authier S, et al. Emergence of fluoroquinolones as the predominant risk factor for clostridium difficile-associated diarrhea: a cohort study during an epidemic in quebec. Clin Infect Dis 2005;41:1254-60.

Å uljagić V, ÄorÄ‘ević D, Lazić S, Mijović B. Epidemiological characteristics of nosocomial diarrhea caused by clostridium difficile in a tertiary level hospital in serbia. Srp Arh Celok Lek 2013;141:482-9.

Å uljagić V, Jevtić M, ÄorÄ‘ević B, Jovelić A. Surgical site infections in a tertiary health care center: prospective cohort study. Surgery Today 2010;40:763-71.

Work report of the section for prevention and control of nosocomial infections in, Treatment Sector, Military Medical Academy, Belgrade; 2012.

Marković-Denić Lj, Å uljagić V, Mijović B, Ćosić G, Tiodorović B, Carević B, et al. Treća nacionalna studija prevalence bolniÄkih infekcija 2010 [Third National Prevalence Study of Nosocomial Infections in 2010], Ministry of Health of the Republic of Serbia, Belgrade; 2012.

Published

01-05-2016

How to Cite

BRUSIC-RENAUD, J., M. Antunovic, and V. SULJAGIC. “THE ANALYSIS OF ANTIBIOTIC CONSUMPTION WITHIN THE TERTIARY HEALTHCARE INSTITUTION IN SERBIA DURING 10-YEAR PERIOD (2001-2010)”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 5, May 2016, pp. 401-3, https://journals.innovareacademics.in/index.php/ijpps/article/view/9756.

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Section

Short Communication(s)