• Rabi Narayan Panigrahy Department of Pharmaceutics, School of Pharmacy, Nalla Narasimha Reddy Education Society’s Group of Institutions, Chowdariguda, Ghatkesar, Hyderabad 500088
  • Sindhura Gudipati Nalla Narasimha Reddy Education Society’s Group of Institutions
  • Krishna Mohan Chinnala Nalla Narasimha Reddy Education Society’s Group of Institutions


Hypertension, Ex vivo mucoadhesion strength, Carbopol, Atenolol


Objective: A combination of the Floating-Bioadhesive system will overcome the drawbacks of floating & bioadhesive systems if used alone and will have a significant effect on improving the therapeutic effect of the drug involved. The present study involves the formulation and in vitro evaluation of atenolol floating-Bioadhesive tablet for prolonged residence in the stomach for the treatment of hypertension.

Methods: The tablets were prepared by direct compression method using directly compressible polymers such as, Hydroxy Propyl Methyl Cellulose (HPMC) K15M, Guar gum, Carbopol, and sodium alginate. The tablets were evaluated for buoyancy test, mucoadhesion force, swelling study, drug content, ex-vivo mucoadhesion strength and in-vitro release profile. Sodium bicarbonate was used for producing the effervescent base for the buoyancy of tablets.

Results: Formulation F9 contains polymer sodium alginate which has shown highest percentage cumulative drug release up to 99.12%. No significant change was observed in physical appearance, drug content, float ability or in vitro dissolution pattern after storage at 45 °C/75% RH for three months.

Conclusion: In this present research work it was concluded that the cumulative drug release increased when the viscosity and concentration of the polymer was increased. The swelling properties were increased with increasing polymer concentration and contributed to the drug release from the tablet matrix.



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How to Cite

Panigrahy, R. N., S. Gudipati, and K. M. Chinnala. “DESIGN, DEVELOPMENT AND IN VITRO EVALUATION OF COMBINED FLOATING-BIOADHESIVE DRUG DELIVERY SYSTEMS OF ATENOLOL”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 2, Feb. 2016, pp. 41-46,



Original Article(s)