• AMAL A AL MOUSA Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.




Coronavirus, Pandemic, Coronavirus disease 2019, Severe acute respiratory syndrome-associated coronavirus, Syndrome


The coronavirus (CoV) family has many more pathological causes for humans and animals. CoV disease 2019 (COVID-19) has spread very rapidly worldwide is endemic, was first identified, isolated from pneumonia, and sourced to Wuhan is located in central China in 2019. The last reports have proposed that severe acute respiratory syndrome-associated CoV (SARS-CoV) deems altered CoV from bat source that came to many people as a due of zoonosis relocation. CoV was treated as a simple non-fatal virus until 2002, then started showing deaths SARS-CoV-1 from 2003 at a rate of 9.6%, in 2004, the Centers for Disease Control and the World Health Organization (WHO) declared of emergency. Middle East respiratory syndrome CoV has been discovered in dromedaries and has continued to kill humans since 2012, and the WHO was confirmed by the Chinese government of several cases of pneumonia by the end of 2019 and these cases were related to the Seafood Market in Huanan, 2020, was the COVID-19 pandemic, this virus was able to spread rapidly among people in most countries of the world, which made the proportion of mortality is rising very alarmingly. Therefore, all states must be careful and take precautionary measures to avoid infection. In this article, we review the origin of CoVs, their global transmission map, and their path of entry into humans.


Forni D, Cagliani R, Clerici M, Sironi M. Molecular evolution of human coronavirus genomes. Trends Microbiol 2017;25:35-48.

Beaudette FR, Hudson CB. Cultivation of the virus of infectious bronchitis. J Am Vet Med A 1937;90:51-6.

Cheever FS, Daniels JB, Pappenheimer AM, Bailey OT. A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin: I. Isolation and biological properties of the virus. J Exp Med 1949;90:181-94.

Kahn JS, McIntosh K. History and recent advances in coronavirus discovery. Pediatr. Infect Dis J 2005;24:S223-7.

Kumar D, Malviya R, Sharma PK. Corona virus: A review of COVID-19. Eur J Med Oncol 2020;2020:51418.

Tyrrell D, Almeida J, Cunningham C, Dowdle W, Hofstad M, McIntosh K, et al. Coronaviridae. Intervirology 1975;5:76-82.

McIntosh K, Becker WB, Chanock RM. Growth in suckling-mouse brain of “IBV-like” viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci USA 1967;58:2268-73.

Lai MM, Perlman S, Anderson L. Coronaviridae. In: Knipe DM, Howley PM, editors. Fields Virology. Philadelphia, PA, USA: Lippincott Williams and Wilkins; 2007. p. 1305-18.

World Health Organization. Summary of Probable SARS Cases with Onset of Illness from 1 November 2002 to 31 July 2003. Geneva: World Health Organization; 2003. Available from: https://www.who.int/csr/ sars/country/table 2004_04_21/en. [Last accessed on 2020 Mar 10].

Guan Y, Zheng B, He Y, Liu X, Zhuang Z, Cheung C, et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 2003;302:276-8.

Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 2019;17:181-92.

Hu B, Zeng LP, Yang XL, Ge XY, Zhang W, Li B, et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog 2017;13:e1006698.

World Health Organization. Coronavirus Disease 2019 (COVID-19) Situation Report 94, Data as Received by WHO national authorities by 10:00 CEST, 23 April 2020. Geneva: World Health Organization; 2020.

Centers for Disease Control and Prevention. Outbreak of severe acute respiratory syndrome--worldwide, 2003. MMWR Morb Mortal Wkly Rep 2003;52:241-6.

Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003;36:19-25.

World Health Organization. WHO Statement Regarding Cluster of Pneumonia Cases in Wuhan, China. Geneva: World Health Organization; 2020. Available from: https://www.who.int/china/news/detail/09- 01-2020-whostatement- regarding-cluster-of pneumoniacases-in-wuhanchina. [Last accessed on 2020 Jan 14].

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727-33.

Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, andcharacteristics of human coronaviruses. J Adv Res 2020;24:91-8.

Yang L, Wu Z, Ren X, Yang F, He G, Zhang J, et al. Novel SARS-like betacoronaviruses in bats, China, 2011. Emerg Infect Dis 2013;19: 989-91.

Menachery VD, Yount BL, Sims AC, Debbink K, Agnihothram SS, Gralinskim LE, et al. SARS-like WIV1-CoV poised for human emergence. Proc Natl Acad Sci USA 2016;113:3048-53.

Wang N, Li SY, Yang XL, Huang HM, Zhang YJ, Guo H, et al. Serological evidence of bat SARS-related coronavirus infection in humans, China. Virol Sin 2018;33:104-7.

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus infected pneumonia. N Engl J Med 2020;382:1199-207.

Zhang L, Shen FM, Chen F, Lin Z. Origin and evolution of the 2019 novel coronavirus. Clin Infect Dis 2020;71:882-3.

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020;579:270-3.

Zhang Z, Wu Q, Zhang T. Pangolin homology associated with 2019 novel coronavirus. bioRxiv 2020;2020:950253.

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet 2020;395:565-74.

Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, et al. Evolution of the novel coronavirus from the ongoingWuhan outbreak and modelling of its Spike protein for risk of human transmission. Sci China Life Sci 2020;63:457-60.

Xiao K, Zhai J, Feng Y, Zhou N, Zhang X, Zou JJ, et al. Isolation and characterization of 2019-nCoV-like coronavirus from Malayan Pangolins. BioRxiv 2020;2020:951335.

Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target. Intensive Care Med 2020;3:1-5.

Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. J Virol 2020;94:e00127-20.

Liu P, Chen W, Chen JP. Viral metagenomics revealed sendai virus and coronavirus infection of Malayan pangolins (Manis javanica). Viruses 2019;11:979.

Li X, Zai J, Zhao Q, Nie Q, Li Y, Foley BT, et al. Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2. J Med Virol 2020;92:602-61.

Liu Z, Xiao X, Wei X, Li J, Yang J, Tan H, et al. Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. J Med Virol 2020;92:595-601.

Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020;26:450-2.



How to Cite

AL MOUSA, A. A. (2021). A REVIEW OF THE HISTORY OF THE CORONAVIRUS DISEASE 2019. Innovare Journal of Sciences, 9(3), 1–3. https://doi.org/10.22159/ijs.2021.v9i3.40836



Original Article(s)