ASSESSMENT OF α- AMYLASE INHIBITORY ACTION OF SOME EDIBLE PLANT SOURCES
Abstract
Diabetes mellitus is one of the major causes for various manifestations of diseases and clinical complications. Plants are good sources of medicinal compounds and some are traditionally used to control Diabetes mellitus. In this study, the anti-diabetic potential of some edible plants was assessed by α-amylase inhibition assay. Among the studied plants, the extracts of Amaranthus dubius and Alternanthera sessilis were found to possess better inhibition potential against α-amylase enzyme. Acarbose and metformin used as standards for reference showed 67% and 48% inhibition efficiency respectively at a concentration of 250 µg/mL and 500 µg/mL. The results of the study ascertain the use of plants in the control of Diabetes mellitus. The inhibitory action of α-amylase mediated through the synergistic action of the phytoconstituents in the plants, lowers the glycemic level, reducing the risks associated with a sudden increase in blood sugar. The results of the study demonstrate the successful use of in vitro models in screening the plant sources for anti-diabetic activity.Â
References
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