ASSESSMENT OF URIC ACID IN POST-MENOPAUSAL OSTEOPOROTIC WOMEN
Abstract
ABSTRACT
Objective: Osteoporosis is a quite common in post-menopausal women due to estrogen deficiency. Uric acid (UA) concentration has found some
controversial association with bone mineral density (BMD). Hence, the role of UA may be beneficial to know due to the sign and symptoms presented
by osteoporosis patients.
Methods: A total of 79 post-menopausal women were recruited without having a previous history of osteoporosis or the secondary osteoporosis.
Their BMD was estimated by estimating T-score and Z-score at the tibia and radius level. Total calcium ionized calcium, serum phosphate, alkaline
phosphatase (ALP), and UA level were estimated by a colorimetric method.
Results and Conclusions: There were 38 women having osteoporosis and remaining 41 with pre-osteoporosis or osteopenia. Significant resultswere obtained between these groups. Total calcium and ionized calcium were higher is osteopenic group and the result highly significant (<0.001).Serum concentration of phosphate and ALP were significantly (<0.01) higher in the osteoporotic group. The UA level was significantly higher(<0.001) in the osteoporotic women. There were positive association (standardized β=0.265, p=0.018) serum UA and ALP in the study group. Inconclusion, post-menopausal women with pre-osteoporosis as well as osteoporosis are characterized by elevated concentration of UA. The role ofUA in bone loss disorder could not be neglected as hyperuricemia may give rise to several other life-threatening diseases associated with this, incoming future.
Keywords: Osteoporosis, Osteopenia, Uric acid, Bone mineral density.
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