ASSESSMENT OF URIC ACID IN POST-MENOPAUSAL OSTEOPOROTIC WOMEN

Authors

  • Preeti Sharma
  • Rachna Sharma
  • Pradeep Kumar Santosh University
  • Gaurav Gupta

Abstract

ABSTRACT
Objective: Osteoporosis is a quite common in post-menopausal women due to estrogen deficiency. Uric acid (UA) concentration has found some
controversial association with bone mineral density (BMD). Hence, the role of UA may be beneficial to know due to the sign and symptoms presented
by osteoporosis patients.
Methods: A total of 79 post-menopausal women were recruited without having a previous history of osteoporosis or the secondary osteoporosis.
Their BMD was estimated by estimating T-score and Z-score at the tibia and radius level. Total calcium ionized calcium, serum phosphate, alkaline
phosphatase (ALP), and UA level were estimated by a colorimetric method.
Results and Conclusions: There were 38 women having osteoporosis and remaining 41 with pre-osteoporosis or osteopenia. Significant resultswere obtained between these groups. Total calcium and ionized calcium were higher is osteopenic group and the result highly significant (<0.001).Serum concentration of phosphate and ALP were significantly (<0.01) higher in the osteoporotic group. The UA level was significantly higher(<0.001) in the osteoporotic women. There were positive association (standardized β=0.265, p=0.018) serum UA and ALP in the study group. Inconclusion, post-menopausal women with pre-osteoporosis as well as osteoporosis are characterized by elevated concentration of UA. The role ofUA in bone loss disorder could not be neglected as hyperuricemia may give rise to several other life-threatening diseases associated with this, incoming future.
Keywords: Osteoporosis, Osteopenia, Uric acid, Bone mineral density.

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Author Biography

Pradeep Kumar, Santosh University

Professor of Biochemistry

References

REFERENCES

Guggenbuhl P. Osteoporosis in males and females: Is there really a

difference? Joint Bone Spine 2009;76(6):595-601.

Riggs BL. The mechanisms of estrogen regulation of bone resorption.

J Clin Invest 2000;106:1203-4.

Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R,

Reginster JY; Scientific Advisory Board of the European Society for

Clinical and Economic Aspects of Osteoporosis and Osteoarthritis

(ESCEO) and the Committee of Scientific Advisors of the International

Osteoporosis Foundation (IOF). European guidance for the diagnosis

and management of osteoporosis in postmenopausal women.

Osteoporos Int 2013;24(1):23-57.

Gronholz MJ. Prevention, diagnosis, and management of osteoporosisrelated

fracture:

A

multifactoral osteopathic

approach.

J

Am

Osteopath

Assoc

;108(10):575-85.

Becker BF, Reinholz N, Leipert B, Raschke P, Permanetter B,

Gerlach E. Role of uric acid as an endogenous radical scavenger and

antioxidant. Chest 1991;100 (3 Suppl):176s-81s.

Nabipour I, Sambrook PN, Blyth FM, Janu MR, Waite LM,

Naganathan V, et al. Serum uric acid is associated with bone health in

older men: A cross-sectional population-based study. J Bone Miner Res

;26(5):955-64.

Veronese N, Bolzetta F, De Rui M, Maggi S, Noale M, Zambon S, et al.

Serum uric acid and incident osteoporotic fractures in old people: The

PRO.V.A study. Bone 2015;79:183-9.

Glantzounis GK, Tsimoyiannis EC, Kappas AM, Galaris DA. Uric acid

and oxidative stress. Curr Pharm Des 2005;11:4145-51.

Alderman M, Aiyer KJ. Uric acid: Role in cardiovascular disease and

effects of losartan. Curr Med Res Opin 2004;20(3):369-79.

Warren TY, Barry V, Hooker SP, Sui X, Church TS, Blair SN. Sedentary

behaviors increase risk of cardiovascular disease mortality in men. Med

Sci Sports Exerc 2010;42(5):879-85.

Grassi D, Ferri L, Desideri G, Di Giosia P, Cheli P, Del Pinto R, et al.

Chronic hyperuricemia, uric acid deposit and cardiovascular risk. Curr

Pharm Des 2013;19(13):2432-8.

National Osteoporosis Foundation. Available from: http://www.nof.org/

articles/743. [Last accessed on 2015 Nov 20].

Burtis CA, Ashwood ER, Burns DE. Tietz Fundamentals of Clinical

Chemistry. 6

ed. Philadelphia, PA: WB Saunders; 1994. p. 715-21.

Buchanan MJ, Isdale IC, Rose BS. Serum uric acid estimation chemical

th

and enzymatic methods compared. Ann Rheum Dis 1965;24:285-8.

Christenson ES, Jiang X, Kagan R, Schnatz P. Osteoporosis management

in post-menopausal women. Minerva Ginecol 2012;64(3):181-94.

Mukaiyama K, Kamimura M, Uchiyama S, Ikegami S, Nakamura Y,

Kato H. Elevation of serum alkaline phosphatase (ALP) level in

postmenopausal women is caused by high bone turnover. Aging Clin

Exp Res 2015;27(4):413-8.

Ishii S, Miyao M, Mizuno Y, Tanaka-Ishikawa M, Akishita M, Ouchi Y.

Association between serum uric acid and lumbar spine bone mineral

density in peri- and postmenopausal Japanese women. Osteoporos Int

;25(3):1099-105.

Lin X, Zhao C, Qin A, Hong D, Liu W, Huang K, et al. Association

between serum uric acid and bone health in general population: A large

and multicentre study. Oncotarget 2015;6(34):35395-403.

Kim BJ, Baek S, Ahn SH, Kim SH, Jo MW, Bae SJ, et al. Higher serum

uric acid as a protective factor against incident osteoporotic fractures in

Korean men: A longitudinal study using the National Claim Registry.

Osteoporos Int 2014;25(7):1837-44.

Chen L, Peng Y, Fang F, Chen J, Pan L, You L. Correlation of serum

uric acid with bone mineral density and fragility fracture in patients

with primary osteoporosis: A single-center retrospective study of

cases. Int J Clin Exp Med 2015;8(4):6291-4.

Makovey J, Macara M, Chen JS, Hayward CS, March L, Seibel MJ,

et al. Serum uric acid plays a protective role for bone loss in

peri- and postmenopausal women: A longitudinal study. Bone

;52(1):400-6.

Ahn SH, Lee SH, Kim BJ, Lim KH, Bae SJ, Kim EH, et al. Higher serum

uric acid is associated with higher bone mass, lower bone turnover,

and lower prevalence of vertebral fracture in healthy postmenopausal

women. Osteoporos Int 2013;24(12):2961-70.

Published

01-03-2016

How to Cite

Sharma, P., R. Sharma, P. Kumar, and G. Gupta. “ASSESSMENT OF URIC ACID IN POST-MENOPAUSAL OSTEOPOROTIC WOMEN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, Mar. 2016, pp. 138-9, https://journals.innovareacademics.in/index.php/ajpcr/article/view/10147.

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