ZERUMBONE, A NATURAL PLANT DIETARY COMPOUND INDUCES EXPRESSION OF INTERLEUKIN-12P70 CYTOKINE IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS

Swagatika Dash; Monalisa Ray; Abtar Mishra; Sajad Shahbazi; Gopinath Achary K; Sanghamitra Nayak; Shikha Singh

doi:10.22159/ajpcr.2016.v9s3.13584

Authors

Swagatika Dash
Monalisa Ray
Abtar Mishra
Sajad Shahbazi
Gopinath Achary K
Sanghamitra Nayak
Shikha Singh

DOI:

https://doi.org/10.22159/ajpcr.2016.v9s3.13584

Abstract

ABSTRACT
Objective: Despite possessing many biological activities as antiproliferative, antioxidant, anti-inflammatory, and anticancerous, and zerumbone lacks
any evidence for its immunomodulatory activity. This naturally occurring dietary compound needs to be developed as drug to support therapeutic
claims in various infections and diseases.
Methods: Hence, in this study, the immunomodulatory effects of zerumbone were investigated by evaluating the effect of this compound toward the
lymphocytes proliferation in human peripheral blood mononuclear cells.
Results: Lymphocyte proliferation assay showed that zerumbone was able to activate human lymphocytes at dosage-dependent manner at the highest
concentration 40 Î¼l/mL. The production of human interleukin-12p70 cytokine in culture supernatant from activated lymphocytes was upregulated
by zerumbone at 24 hrs and gradually decreased at 48 hrs. Hence, the study confirms the immunomodulatory activity of zerumbone which play an
important role in boosting up the immune system through cytokine production in dosage dependent manner.
Conclusion: The study concludes that zerumbone could be used as a lead molecule in herbal therapeutic world as an immunomodulatory drug in the
treatment of chronic infections and various autoimmune disorders.
Keywords: Zerumbone, Peripheral blood mononuclear cells, Immunomodulation, Cytokine, Lymphocyte proliferation.

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