EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF THE AERIAL PARTS OF PHYLLANTHUS RETICULATES AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN RATS
Objective: The present study deals with evaluation of hepatoprotective effect against paracetamol induced hepatitis in rats and in-vitro antioxidant
activity of aerial parts of ethanolic extract (70%) of Phyllanthus reticulates.
Methods: Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and total Bilirubin were tested in both treated and
Results: Treatment with ethanolic extract of Phyllanthus reticulates (400 mg/kg) has brought back the altered levels of biochemical markers to the
near normal level which is comparable with the standard drug Silymarin.
Conclusion: Further the in-vitro antioxidant activity and total phenolic content showed significant result which in turn encourages further evaluation
of this plant in future.
Keywords: Phyllanthus, Hepatitis, Biochemical markers, Antioxidant activity, Total phenolic content.
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Table 2: Effect of ethanolic extract of P. reticulates on some biochemical parameters of paracetamol intoxicated rats
EATE (400 mg/kg)
Silymarin (25 mg/kg)
Values are meanÂ±SEM, (n=6), ap<0.01: Paracetamol control group compared with normal control group, *p<0.01: Experimental groups compared with paracetamol control group, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase, ALP: Alkaline phosphate, SEM: Standard error of mean, P. reticulates: Phyllanthus reticulatus
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