EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF THE AERIAL PARTS OF PHYLLANTHUS RETICULATES AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN RATS
Abstract
ABSTRACT
Objective: The present study deals with evaluation of hepatoprotective effect against paracetamol induced hepatitis in rats and in-vitro antioxidant
activity of aerial parts of ethanolic extract (70%) of Phyllanthus reticulates.
Methods: Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and total Bilirubin were tested in both treated and
untreated groups.
Results: Treatment with ethanolic extract of Phyllanthus reticulates (400 mg/kg) has brought back the altered levels of biochemical markers to the
near normal level which is comparable with the standard drug Silymarin.
Conclusion: Further the in-vitro antioxidant activity and total phenolic content showed significant result which in turn encourages further evaluation
of this plant in future.
Keywords: Phyllanthus, Hepatitis, Biochemical markers, Antioxidant activity, Total phenolic content.
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References
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Table 2: Effect of ethanolic extract of P. reticulates on some biochemical parameters of paracetamol intoxicated rats
Parameters
Normal control
Paracetamol control
EATE (400 mg/kg)
Silymarin (25 mg/kg)
AST (U/L)
7±4.3
3±8.8a
7±6.2***
3±5.7***
ALT (U/L)
2±1.2
5±5.9a
5±2.1**
08±1.8**
ALP (U/L)
21±3.82
67±4.04a
22±2.58***
±10.9***
Bilirubin (mg/dl)
10±0.04
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22±0.05*
14±0.04*
Values are mean±SEM, (n=6), ap<0.01: Paracetamol control group compared with normal control group, *p<0.01: Experimental groups compared with paracetamol control group, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase, ALP: Alkaline phosphate, SEM: Standard error of mean, P. reticulates: Phyllanthus reticulatus
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