PHYSICAL, CHEMICAL CHARACTERISTICS AND RELEASE RATE OF MELOXICAM FROM NANOSTRUCTURED LIPID CARRIERS (NLC) SYSTEM USING SOME CONCENTRATION RATIOS OF MONOSTEARIN AND ALPHA TOCOPHEROL ACETATE LIPID MATRIX
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i2.14806Abstract
Objective: The objective of this research is to develop nanostructured lipid carriers (NLC) of meloxicam (MLX) for topical application using monostearin and alpha-tocopherol as lipid matrix.
Methods: MLX-NLC was prepared by high-shear homogenization, and it was characterized for organoleptic, pH, viscosity, particle size and size distribution, zeta potential, crystallinity, morphology, and entrapment efficiency. The six different ratios of solid and liquid lipid matrix were
70:30, 75:25, 80:20, 85:15, 90:10, and 95:5, respectively.
Results: The pH value of all formulas met the pH range of topical dosage at 4.5-6.5. Viscosity test showed that a trend toward the decrease in viscosity with the increase in alpha-tocopherol content was observed. The results of particle size test proved that all six NLC system formulas have <1000 nm particle size with a quite narrow particle size distribution. Scanning electron microscope revealed nearly spherical shape NLC with negligible effect ratios of solid and liquid lipid on the particle morphology. The X-ray diffraction result showed the decreasing of peaks intensity of MLX-NLC system. It showed that MLX in NLC system is amorphous. The result showed that the increasing concentration of liquid lipid in NLC system caused the rising entrapment efficiency of MLX.
Conclusion: The result of this research indicates that the concentration ratio of monostearin and alpha-tocopherol acetate affects the physical and chemical characteristics of NLC system.
Keywords: Nanostructured lipid carriers, Meloxicam, Monostearin, Physical and chemical characteristics, Entrapment efficiency.
Â
Downloads
References
Sweetman SC. Martindale The Complete Drug Reference. 26th ed.
USA: Pharmaceutical Press.
Bachhav YG, Patravale VB. Formulation of meloxicam gel for topical application: In vitro and in vivo evaluation. Acta Pharm
;60(2):153-63.
Khurana S, Jain NK, Bedi PM. Development and characterization of a novel controlled release drug delivery system based on nanostructured lipid carriers gel for meloxicam. Life Sci 2013;93(21):763-72.
Souto EB, Muller RH. Lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers) for cosmetic, dermal, and transdermal applications. Drug Pharm Sci 2007;166:213-32.
Han F, Li S, Yin R, Liu H, Xu L. Effect of surfactants on the formation and characterization of a new type of colloidal drug delivery system nanostructured lipid carriers. Int J Pharm 2008;315(1):210-6.
Yuan H, Wang LL, Du YZ, You J, Hu FQ, Zeng S. Preparation and characteristics of nanostructured lipid carriers for control-releasing progesterone by melt-emulsification. Colloids Surf B Biointerfaces
;60(2):174-9.
Kumar SG, Mishra DN. Preparation, characterization and in vivo dissolution studies of solid dispersion of meloxicam with PEG 6000. Pharm Soc Jpn 2006;126(8):657-64.
Khurana S, Jain NK, Bedi PM. Development of nanostructured lipid carriers for controlled delivery of mefenamic acid. Int J Biomed Nanosci Nanotechnol 2012;2:232-50.
Simon P. Formulasi dan Uji Penetrasi Mikroemulsi Natrium Diklofenak Dengan Metode Sel Difusi Franz dan Metode Tape Stripping, Tesis. Indonesia: Universitas Indonesia; 2012.
Sinko PJ, Singh Y. Martin’s Physical Pharmacy and Pharmaceutical Sciences: Physical Chemical and Biopharmaceutical Principles in the Pharmaceutical Sciences. 6th ed. Philadelphia PA: Lippincott Williams
& Wilkins, A Wolters Kluwer; 2011.
Jenning V, Gohla S. Comparison of wax and glyceride solid lipid nanoparticles (SLN). Int J Pharm 2000;196(2):219-22.
Rosita N, Setyawan D, Soeratri W, Mrtodihardjo S. Physical characterization of beeswax and glyceryl monostearat binary system to predict characteristics of solid lipid nanoparticle (SLN) loaded para methoxy cinnamic acid (PMCA). Int J Pharm Pharm Sci 2014;6
Suppl 2:939-45.
Xia D, Cui F, Gan Y, Mu H, Yang M. Design of lipid matrix particles for fenofibrate: Effect of polymorphism of glycerol monostearate on drug incorporation and release. J Pharm Sci 2014;103(3):697-705.
Nastruzi C. Characterization of solid lipid nano and microparticles.
Liposphere in Drug Targets and Delivery. London: CRC Press;
p. 41-66
Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery - A review of the state of the art. Eur J Pharm Biopharm 2000;50(1):161-77.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
